{"id":"https://openalex.org/W2013848755","doi":"https://doi.org/10.1016/j.jchf.2013.12.002","title":"Randomized, Double-Blind, Placebo-Controlled Study of Sitaxsentan to Improve Impaired Exercise Tolerance in Patients With Heart Failure and a Preserved Ejection Fraction","display_name":"Randomized, Double-Blind, Placebo-Controlled Study of Sitaxsentan to Improve Impaired Exercise Tolerance in Patients With Heart Failure and a Preserved Ejection Fraction","publication_year":2014,"publication_date":"2014-02-26","ids":{"openalex":"https://openalex.org/W2013848755","doi":"https://doi.org/10.1016/j.jchf.2013.12.002","mag":"2013848755","pmid":"https://pubmed.ncbi.nlm.nih.gov/24720918"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchf.2013.12.002","doi":"https://doi.org/10.1016/j.jchf.2013.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jchf.2013.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213177914000237/pdf","source":{"id":"https://openalex.org/S2764825379","display_name":"JACC Heart Failure","issn_l":"2213-1779","issn":["2213-1779","2213-1787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Heart Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213177914000237/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047833899","display_name":"Michael R. Zile","orcid":"https://orcid.org/0000-0001-7076-221X","observed_orcids":["https://orcid.org/0000-0001-7076-221X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael R. Zile","raw_affiliation_strings":["Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina. Electronic address: zilem@musc.edu","Division of Cardiology, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina. Electronic address: zilem@musc.edu","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"Division of Cardiology, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025726013","display_name":"Robert C. Bourge","orcid":"https://orcid.org/0000-0001-9035-4133","observed_orcids":["https://orcid.org/0000-0001-9035-4133"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Bourge","raw_affiliation_strings":["Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028644714","display_name":"Margaret M. Redfield","orcid":"https://orcid.org/0000-0002-0946-7518","observed_orcids":["https://orcid.org/0000-0002-0946-7518"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M. Redfield","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112095021","display_name":"Duo Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duo Zhou","raw_affiliation_strings":["Pfizer, Inc., Groton, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, Inc., Groton, Connecticut","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014049392","display_name":"Catalin F. Baicu","orcid":"https://orcid.org/0000-0002-7843-4402","observed_orcids":["https://orcid.org/0000-0002-7843-4402"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catalin F. Baicu","raw_affiliation_strings":["Division of Cardiology, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Medical University of South Carolina, and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013401681","display_name":"William C. Little","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Little","raw_affiliation_strings":["Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047833899"],"corresponding_institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":7.3101,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.97759188,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"2","first_page":"123","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sitaxsentan","display_name":"sitaxsentan","score":0.9940000176429749},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treadmill-exercise-time","display_name":"treadmill exercise time","score":0.8659999966621399},{"id":"https://openalex.org/keywords/diastolic-function","display_name":"diastolic function","score":0.9549999833106995},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.9789999723434448},{"id":"https://openalex.org/keywords/minnesota-living-with-heart-failure-questionnaire","display_name":"Minnesota Living with Heart Failure Questionnaire","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nyha-functional-class","display_name":"NYHA functional class","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8262744545936584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8237805962562561},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.781663179397583},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6889122724533081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6830770969390869},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6680699586868286},{"id":"https://openalex.org/C2779781611","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Diastolic heart failure","level":4,"score":0.5078156590461731},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4972234070301056},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4568922519683838},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.4360792934894562},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3182380795478821},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.15722525119781494},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jchf.2013.12.002","doi":"https://doi.org/10.1016/j.jchf.2013.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jchf.2013.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213177914000237/pdf","source":{"id":"https://openalex.org/S2764825379","display_name":"JACC Heart Failure","issn_l":"2213-1779","issn":["2213-1779","2213-1787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Heart Failure","raw_type":"journal-article"},{"id":"pmid:24720918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24720918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Heart failure","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jchf.2013.12.002","doi":"https://doi.org/10.1016/j.jchf.2013.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jchf.2013.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213177914000237/pdf","source":{"id":"https://openalex.org/S2764825379","display_name":"JACC Heart Failure","issn_l":"2213-1779","issn":["2213-1779","2213-1787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Heart Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G2759414028","display_name":null,"funder_award_id":"5101CX000415","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8663854189","display_name":null,"funder_award_id":"5101CX000415-02","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G99361962","display_name":null,"funder_award_id":"5101BX000487","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013848755.pdf","grobid_xml":"https://content.openalex.org/works/W2013848755.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1518281645","https://openalex.org/W1900184106","https://openalex.org/W1979604318","https://openalex.org/W2001626665","https://openalex.org/W2004909630","https://openalex.org/W2023952303","https://openalex.org/W2024153605","https://openalex.org/W2026881482","https://openalex.org/W2028139057","https://openalex.org/W2034559923","https://openalex.org/W2039767184","https://openalex.org/W2042526294","https://openalex.org/W2057047340","https://openalex.org/W2057982867","https://openalex.org/W2068519950","https://openalex.org/W2073089669","https://openalex.org/W2086291738","https://openalex.org/W2088744341","https://openalex.org/W2104825830","https://openalex.org/W2105441859","https://openalex.org/W2109615331","https://openalex.org/W2115305066","https://openalex.org/W2118736943","https://openalex.org/W2120590896","https://openalex.org/W2122520680","https://openalex.org/W2127254785","https://openalex.org/W2127712541","https://openalex.org/W2137784332","https://openalex.org/W2148910374","https://openalex.org/W2157276521","https://openalex.org/W2159819952","https://openalex.org/W2161469339","https://openalex.org/W2162804111","https://openalex.org/W2166504467","https://openalex.org/W2168017932","https://openalex.org/W2320290562","https://openalex.org/W3190984494"],"related_works":["https://openalex.org/W2061613053","https://openalex.org/W2906245407","https://openalex.org/W2133050514","https://openalex.org/W2160782994","https://openalex.org/W1998574426","https://openalex.org/W2021191584","https://openalex.org/W4408311886","https://openalex.org/W1981136680","https://openalex.org/W2073379244","https://openalex.org/W2171108647"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
