{"id":"https://openalex.org/W2013832080","doi":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","title":"The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans","display_name":"The Core of the Polycomb Repressive Complex Is Compositionally and Functionally Conserved in Flies and Humans","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2013832080","doi":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","mag":"2013832080","pmid":"https://pubmed.ncbi.nlm.nih.gov/12167701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/134016"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.22.17.6070-6078.2002","doi":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC134016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026357113","display_name":"Stuart S. Levine","orcid":"https://orcid.org/0000-0001-7363-562X","observed_orcids":["https://orcid.org/0000-0001-7363-562X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart S. Levine","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","Department of Molecular Biology Massachusetts General Hospital Boston, Massachusetts 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Molecular Biology Massachusetts General Hospital Boston, Massachusetts 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063782372","display_name":"Alona Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alona Weiss","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082796663","display_name":"Hediye Erdjument\u2010Bromage","orcid":"https://orcid.org/0000-0003-0224-3594","observed_orcids":["https://orcid.org/0000-0003-0224-3594"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hediye Erdjument-Bromage","raw_affiliation_strings":["Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040863416","display_name":"Zhaohui Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaohui Shao","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009347072","display_name":"Paul Tempst","orcid":"https://orcid.org/0000-0002-6680-3987","observed_orcids":["https://orcid.org/0000-0002-6680-3987"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Tempst","raw_affiliation_strings":["Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014149423","display_name":"Robert E. Kingston","orcid":"https://orcid.org/0000-0003-3628-4335","observed_orcids":["https://orcid.org/0000-0003-3628-4335"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Kingston","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7927,"has_fulltext":false,"cited_by_count":388,"citation_normalized_percentile":{"value":0.97221902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"22","issue":"17","first_page":"6070","last_page":"6078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.8270000219345093},{"id":"https://openalex.org/keywords/polycomb-repressive-complex","display_name":"polycomb repressive complex","score":0.9700000286102295},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nucleosome-structure","display_name":"nucleosome structure","score":0.6299999952316284},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.6259999871253967},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.6660000085830688},{"id":"https://openalex.org/keywords/protein-complex-composition","display_name":"protein complex composition","score":0.6439999938011169},{"id":"https://openalex.org/keywords/evolutionary-conservation","display_name":"evolutionary conservation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9352424144744873},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.6123934388160706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4900308847427368},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.47487613558769226},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43736863136291504},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.427522748708725},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3837750554084778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33046889305114746},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.2829442024230957},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23442396521568298},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.2020854353904724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18983522057533264},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.18518590927124023},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005801","descriptor_name":"Genes, Homeobox","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017412","descriptor_name":"Ribonucleoprotein, U1 Small Nuclear","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063146","descriptor_name":"Polycomb-Group Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063150","descriptor_name":"Polycomb Repressive Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.22.17.6070-6078.2002","doi":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.17.6070-6078.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:136871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC134016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:134016","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/134016","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:12167701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12167701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.1022","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.1022","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://mcb.asm.org/content/22/17/6070.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:136871","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC134016","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W129013773","https://openalex.org/W1510180204","https://openalex.org/W1536466400","https://openalex.org/W1652691961","https://openalex.org/W1656315914","https://openalex.org/W1658548139","https://openalex.org/W1851775837","https://openalex.org/W1865585336","https://openalex.org/W1890342947","https://openalex.org/W1900883967","https://openalex.org/W1911331852","https://openalex.org/W1933538082","https://openalex.org/W1964975433","https://openalex.org/W1967929692","https://openalex.org/W1972750101","https://openalex.org/W1977289089","https://openalex.org/W1977895957","https://openalex.org/W2000376652","https://openalex.org/W2015368358","https://openalex.org/W2017818411","https://openalex.org/W2020536333","https://openalex.org/W2022237004","https://openalex.org/W2024615596","https://openalex.org/W2027657247","https://openalex.org/W2036516702","https://openalex.org/W2044385397","https://openalex.org/W2046140706","https://openalex.org/W2047143392","https://openalex.org/W2053881125","https://openalex.org/W2057475298","https://openalex.org/W2070761003","https://openalex.org/W2071023317","https://openalex.org/W2075430280","https://openalex.org/W2076030858","https://openalex.org/W2081338850","https://openalex.org/W2085584897","https://openalex.org/W2087172939","https://openalex.org/W2088335689","https://openalex.org/W2091677482","https://openalex.org/W2094972117","https://openalex.org/W2100885802","https://openalex.org/W2107350929","https://openalex.org/W2108758622","https://openalex.org/W2115260024","https://openalex.org/W2117925742","https://openalex.org/W2118083063","https://openalex.org/W2119357727","https://openalex.org/W2119855916","https://openalex.org/W2121437390","https://openalex.org/W2123791127","https://openalex.org/W2128962905","https://openalex.org/W2129314778","https://openalex.org/W2132212013","https://openalex.org/W2135748193","https://openalex.org/W2139844964","https://openalex.org/W2144434845","https://openalex.org/W2154178774","https://openalex.org/W2154185970","https://openalex.org/W2161313400","https://openalex.org/W2161888867","https://openalex.org/W2165862139","https://openalex.org/W2167250543","https://openalex.org/W2167572435","https://openalex.org/W2174739588","https://openalex.org/W2395517692","https://openalex.org/W2404848833"],"related_works":["https://openalex.org/W7099184295","https://openalex.org/W2486606201","https://openalex.org/W2132212013","https://openalex.org/W2492790550","https://openalex.org/W2047143392","https://openalex.org/W4294897846","https://openalex.org/W2089895248","https://openalex.org/W2294108991","https://openalex.org/W2119206510","https://openalex.org/W2258086263"],"abstract_inverted_index":{"The":[0],"Polycomb":[1,102],"group":[2],"(PcG)":[3],"genes":[4,10,41],"are":[5,22,58,70],"required":[6],"to":[7,24,124,181,199],"maintain":[8,31],"homeotic":[9,32],"in":[11,17,38,43,50,116,170],"a":[12,94,100,160,189],"silenced":[13],"state":[14],"during":[15,35],"development":[16],"drosophila":[18,117],"and":[19,21,46,62,72,91,173,201],"mammals":[20],"thought":[23],"form":[25],"several":[26,67],"distinct":[27],"silencing":[28],"complexes":[29],"that":[30,109,191],"gene":[33],"repression":[34],"development.":[36],"Mutations":[37],"the":[39,83,89,131,155,195,203],"PcG":[40,55,68,79,95,113,132,157],"result":[42],"developmental":[44],"defects":[45],"have":[47,98,125,165,175],"been":[48],"implicated":[49],"human":[51,101],"cancer.":[52],"Although":[53],"some":[54],"protein":[56],"domains":[57],"conserved":[59],"between":[60],"flies":[61],"humans,":[63],"substantial":[64],"regions":[65],"of":[66,77,85,93,112,135,143,152,154,185,197],"proteins":[69,114,134],"divergent":[71],"humans":[73],"contain":[74],"multiple":[75],"versions":[76],"each":[78],"gene.":[80],"To":[81],"determine":[82],"effects":[84],"these":[86],"changes":[87],"on":[88],"composition":[90],"function":[92],"complex,":[96],"we":[97,164],"purified":[99],"repressive":[103],"complex":[104],"from":[105],"HeLa":[106],"cells":[107],"(hPRC-H)":[108],"contains":[110],"homologues":[111,151],"found":[115,123],"embryonic":[118],"PRC1":[119],"(dPRC1).":[120],"hPRC-H":[121,144,174,178],"was":[122],"fewer":[126],"components":[127],"than":[128],"dPRC1,":[129],"retaining":[130],"core":[133,156],"dPRC1":[136,172],"but":[137],"lacking":[138],"most":[139,153],"non-PcG":[140],"proteins.":[141],"Preparations":[142],"contained":[145],"either":[146],"two":[147],"or":[148],"three":[149],"different":[150],"proteins,":[158],"including":[159],"new":[161],"Ph":[162],"homologue":[163],"named":[166],"HPH3.":[167],"Despite":[168],"differences":[169],"composition,":[171],"similar":[176],"functions:":[177],"is":[179],"able":[180],"efficiently":[182],"block":[183,194],"remodeling":[184],"nucleosomal":[186],"arrays":[187],"through":[188],"mechanism":[190],"does":[192],"not":[193],"ability":[196],"nucleases":[198],"access":[200],"cleave":[202],"arrays.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":21}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}