{"id":"https://openalex.org/W2013819796","doi":"https://doi.org/10.1271/bbb.90803","title":"Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1","display_name":"Oligosaccharides from Agar Inhibit Pro-Inflammatory Mediator Release by Inducing Heme Oxygenase 1","publication_year":2010,"publication_date":"2010-04-07","ids":{"openalex":"https://openalex.org/W2013819796","doi":"https://doi.org/10.1271/bbb.90803","mag":"2013819796","pmid":"https://pubmed.ncbi.nlm.nih.gov/20378994"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.90803","doi":"https://doi.org/10.1271/bbb.90803","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.90803","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004975563","display_name":"Tatsuji Enoki","orcid":"https://orcid.org/0009-0003-7454-588X","observed_orcids":["https://orcid.org/0009-0003-7454-588X"]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuji ENOKI","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc., Otsu, Shiga, Japan. enokit@takara-bio.co.jp","Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc., Otsu, Shiga, Japan. enokit@takara-bio.co.jp","institution_ids":["https://openalex.org/I4405274742"]},{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shinji OKUDA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji OKUDA","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085068320","display_name":"Yoko Kudo","orcid":"https://orcid.org/0000-0003-0354-6802","observed_orcids":["https://orcid.org/0000-0003-0354-6802","https://orcid.org/0009-0001-6604-3172"]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko KUDO","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074423765","display_name":"Fuyuko Takashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fuyuko TAKASHIMA","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110698229","display_name":"Hiroaki Sagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki SAGAWA","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102123010","display_name":"Ikunoshin Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274742","display_name":"Takara BIO Inc. (Japan)","ror":"https://ror.org/028t8vy11","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikunoshin KATO","raw_affiliation_strings":["Biotechnology Research Laboratories, Takara Bio Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Laboratories, Takara Bio Inc","institution_ids":["https://openalex.org/I4405274742"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405274742"],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":2.4832,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.87179005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"74","issue":"4","first_page":"766","last_page":"770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.4009000062942505,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.4009000062942505,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.17470000684261322,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agaro-oligosaccharides","display_name":"agaro-oligosaccharides","score":0.9459999799728394},{"id":"https://openalex.org/keywords/agar","display_name":"agar","score":0.6579999923706055},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7419999837875366},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.777999997138977},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8539326190948486},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7222400903701782},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6830524802207947},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6822876930236816},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5638341903686523},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5568853616714478},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5340988039970398},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5023274421691895},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4730457663536072},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4663969874382019},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.4236389398574829},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4214627742767334},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4064687192440033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33480924367904663},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2663077116012573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24317052960395813},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09902903437614441},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07255685329437256},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000362","descriptor_name":"Agar","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055951","descriptor_name":"Functional Food","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.90803","doi":"https://doi.org/10.1271/bbb.90803","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.90803","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:20378994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20378994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W142204211","https://openalex.org/W1481543714","https://openalex.org/W1540820582","https://openalex.org/W1600690434","https://openalex.org/W1966582616","https://openalex.org/W1976665224","https://openalex.org/W2003599597","https://openalex.org/W2005889053","https://openalex.org/W2006217933","https://openalex.org/W2006733242","https://openalex.org/W2024638763","https://openalex.org/W2052305758","https://openalex.org/W2083117490","https://openalex.org/W2094745968","https://openalex.org/W2101840353","https://openalex.org/W2113552021","https://openalex.org/W2113683216","https://openalex.org/W2125795237","https://openalex.org/W2128569634","https://openalex.org/W2145530136","https://openalex.org/W2148391152","https://openalex.org/W2161945201","https://openalex.org/W2409278831"],"related_works":["https://openalex.org/W2030270428","https://openalex.org/W2592709671","https://openalex.org/W2035992556","https://openalex.org/W2319425357","https://openalex.org/W2014929619","https://openalex.org/W3184233101","https://openalex.org/W2914750949","https://openalex.org/W2032764867","https://openalex.org/W3197169400","https://openalex.org/W7218075779"],"abstract_inverted_index":{"We":[0,17,46],"investigated":[1],"whether":[2],"agaro-oligosaccharides":[3,20,53,72],"have":[4,60],"any":[5],"immunological":[6],"effects":[7,51],"on":[8,54],"RAW264.7":[9],"mouse":[10],"macrophages":[11,58],"and":[12,30,39,44,57],"human":[13],"monocytes":[14,43,56],"in":[15,41],"vitro.":[16],"demonstrate":[18,48],"that":[19,49,71],"suppressed":[21],"the":[22],"elevated":[23],"levels":[24],"of":[25,52],"nitric":[26],"oxide,":[27],"prostaglandin":[28],"E(2),":[29],"such":[31],"pro-inflammatory":[32],"cytokines":[33],"as":[34],"tumor":[35],"necrosis":[36],"factor-alpha,":[37],"interleukin-1beta":[38],"interleukin-6":[40],"lipopolysaccharide-stimulated":[42],"macrophages.":[45],"also":[47],"those":[50],"activated":[55],"may":[59],"been":[61],"caused":[62],"by":[63],"heme":[64],"oxygenase-1":[65],"induction.":[66],"It":[67],"is":[68],"therefore":[69],"proposed":[70],"might":[73],"be":[74],"a":[75,79],"good":[76],"candidate":[77],"for":[78],"functional":[80],"food":[81],"to":[82],"prevent":[83],"inflammatory":[84],"diseases.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
