{"id":"https://openalex.org/W2013808106","doi":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","title":"Insulin and the IGF system in the human placenta of normal and diabetic pregnancies","display_name":"Insulin and the IGF system in the human placenta of normal and diabetic pregnancies","publication_year":2009,"publication_date":"2009-05-08","ids":{"openalex":"https://openalex.org/W2013808106","doi":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","mag":"2013808106","pmid":"https://pubmed.ncbi.nlm.nih.gov/19467150","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2714639"},"language":"en","primary_location":{"id":"doi:10.1111/j.1469-7580.2008.01035.x","doi":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","pdf_url":null,"source":{"id":"https://openalex.org/S31465112","display_name":"Journal of Anatomy","issn_l":"0021-8782","issn":["0021-8782","1469-7580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Anatomy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2714639","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064144762","display_name":"Ursula Hiden","orcid":"https://orcid.org/0000-0001-8009-020X","observed_orcids":["https://orcid.org/0000-0001-8009-020X"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Ursula Hiden","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz, Austria. ursula.hiden@meduni-graz.at","Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz, Austria. ursula.hiden@meduni-graz.at","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090144442","display_name":"Elisabeth Glitzner","orcid":"https://orcid.org/0000-0002-1541-4076","observed_orcids":["https://orcid.org/0000-0002-1541-4076"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Elisabeth Glitzner","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Medical University of Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Medical University of Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033100577","display_name":"Michaele Hartmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Michaele Hartmann","raw_affiliation_strings":["Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077236582","display_name":"Gernot Desoy\u00e9","orcid":"https://orcid.org/0000-0002-5715-3230","observed_orcids":["https://orcid.org/0000-0002-5715-3230"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gernot Desoye","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Medical University of Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Medical University of Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064144762"],"corresponding_institution_ids":["https://openalex.org/I202276237"],"apc_list":{"value":4050,"currency":"USD","value_usd":4050},"apc_paid":null,"fwci":1.2476,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.74846206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"215","issue":"1","first_page":"60","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.17159999907016754,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.16529999673366547,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-system","display_name":"insulin-like growth factor system","score":0.8610000014305115},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8529999852180481},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.953000009059906},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.7649999856948853},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.8840000033378601},{"id":"https://openalex.org/keywords/maternal-diabetes","display_name":"maternal diabetes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.6299999952316284},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.8429999947547913},{"id":"https://openalex.org/keywords/placental-angiogenesis","display_name":"placental angiogenesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fetal-growth","display_name":"fetal growth","score":0.8309999704360962},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.7570000290870667},{"id":"https://openalex.org/keywords/placental-endothelium","display_name":"placental endothelium","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.8201566934585571},{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.7556697130203247},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7194646596908569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.679828941822052},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6729375123977661},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6326180100440979},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5249428749084473},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.5148398280143738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5123263597488403},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5110138654708862},{"id":"https://openalex.org/C2779753670","wikidata":"https://www.wikidata.org/wiki/Q2657962","display_name":"Fetal circulation","level":5,"score":0.5032145380973816},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.4997241497039795},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4863350987434387},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.430793821811676},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.40008172392845154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2906593084335327},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.209612637758255},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.20687460899353027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010929","descriptor_name":"Placentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011254","descriptor_name":"Pregnancy in Diabetics","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1469-7580.2008.01035.x","doi":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1469-7580.2008.01035.x","pdf_url":null,"source":{"id":"https://openalex.org/S31465112","display_name":"Journal of Anatomy","issn_l":"0021-8782","issn":["0021-8782","1469-7580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Anatomy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2714639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2714639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anat","raw_type":"Text"},{"id":"pmid:19467150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19467150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anatomy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2714639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2714639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anat","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W20551366","https://openalex.org/W117451605","https://openalex.org/W120537540","https://openalex.org/W151791620","https://openalex.org/W187211481","https://openalex.org/W1536119619","https://openalex.org/W1849493450","https://openalex.org/W1871669466","https://openalex.org/W1966693357","https://openalex.org/W1967899512","https://openalex.org/W1974086084","https://openalex.org/W1978543003","https://openalex.org/W1979943253","https://openalex.org/W1986429916","https://openalex.org/W1991014839","https://openalex.org/W1993534422","https://openalex.org/W1999400388","https://openalex.org/W2000506553","https://openalex.org/W2006484722","https://openalex.org/W2012991517","https://openalex.org/W2018144542","https://openalex.org/W2019685965","https://openalex.org/W2020673502","https://openalex.org/W2021562703","https://openalex.org/W2021708536","https://openalex.org/W2025813501","https://openalex.org/W2025945400","https://openalex.org/W2031722909","https://openalex.org/W2037594642","https://openalex.org/W2041038309","https://openalex.org/W2041384612","https://openalex.org/W2043853723","https://openalex.org/W2045282157","https://openalex.org/W2048967928","https://openalex.org/W2055598444","https://openalex.org/W2056750064","https://openalex.org/W2057888633","https://openalex.org/W2071537738","https://openalex.org/W2073228134","https://openalex.org/W2077333628","https://openalex.org/W2078156035","https://openalex.org/W2082562584","https://openalex.org/W2084162834","https://openalex.org/W2088926562","https://openalex.org/W2089648132","https://openalex.org/W2093455184","https://openalex.org/W2094438647","https://openalex.org/W2102271265","https://openalex.org/W2102496902","https://openalex.org/W2109194598","https://openalex.org/W2109447492","https://openalex.org/W2111633621","https://openalex.org/W2113598335","https://openalex.org/W2115114792","https://openalex.org/W2122235465","https://openalex.org/W2125508002","https://openalex.org/W2142954742","https://openalex.org/W2144678487","https://openalex.org/W2144747931","https://openalex.org/W2146969730","https://openalex.org/W2152814088","https://openalex.org/W2152877944","https://openalex.org/W2153766879","https://openalex.org/W2156371303","https://openalex.org/W2156808865","https://openalex.org/W2161029842","https://openalex.org/W2162059787","https://openalex.org/W2163818708","https://openalex.org/W2168850070","https://openalex.org/W2169892373","https://openalex.org/W2317615139","https://openalex.org/W2320296534","https://openalex.org/W2329488961","https://openalex.org/W2396097667","https://openalex.org/W2409262434","https://openalex.org/W2417056986","https://openalex.org/W2486911420","https://openalex.org/W3211309440","https://openalex.org/W4233477876"],"related_works":["https://openalex.org/W2056971487","https://openalex.org/W1981610400","https://openalex.org/W2017507326","https://openalex.org/W3134808373","https://openalex.org/W2079519217","https://openalex.org/W200991730","https://openalex.org/W2090926389","https://openalex.org/W1972213260","https://openalex.org/W2223922429","https://openalex.org/W2082149692"],"abstract_inverted_index":{"The":[0,40,121],"insulin/insulin-like":[1],"growth":[2,10,113,125],"factor":[3],"(IGF)":[4],"system":[5,19],"regulates":[6],"fetal":[7,34,67,136,145,153],"and":[8,11,24,47,61,72,103,114,118,127,135,144,149],"placental":[9,55,112,119,134,143,147],"development.":[12],"In":[13],"maternal":[14,32,69],"diabetes,":[15,140],"components":[16],"of":[17,45,95,111,123,152],"this":[18],"including":[20],"insulin,":[21,70],"IGF1,":[22,78],"IGF2":[23],"various":[25],"IGF-binding":[26],"proteins":[27],"are":[28,105],"deregulated":[29],"in":[30,37,86,107,133,139],"the":[31,38,59,62,75,79,90,93,98,108,124],"or":[33,36],"circulation,":[35],"placenta.":[39],"placenta":[41],"expresses":[42],"considerable":[43],"amounts":[44],"insulin":[46,60,80],"IGF1":[48,63,71],"receptors":[49,129],"at":[50,92,100],"distinct":[51],"locations":[52],"on":[53],"both":[54],"surfaces.":[56],"This":[57],"makes":[58],"receptor":[64,76,81],"accessible":[65],"to":[66,97],"and/or":[68],"IGF2.":[73],"Unlike":[74],"for":[77],"undergoes":[82],"a":[83],"gestational":[84],"change":[85],"expression":[87],"site":[88],"from":[89],"trophoblast":[91,116],"beginning":[94],"pregnancy":[96],"endothelium":[99],"term.":[101],"Insulin":[102],"IGFs":[104],"implicated":[106],"receptor-mediated":[109],"regulation":[110],"transport,":[115],"invasion":[117],"angiogenesis.":[120],"dysregulation":[122],"factors":[126],"their":[128],"may":[130],"be":[131],"involved":[132],"changes":[137],"observed":[138],"i.e.":[141],"enhanced":[142],"growth,":[146],"hypervascularization":[148],"higher":[150],"levels":[151],"plasma":[154],"amino":[155],"acids.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}