{"id":"https://openalex.org/W2013807473","doi":"https://doi.org/10.1177/016173461203400102","title":"Synergistic Effects of Ultrasound-Activated Microbubbles and Doxorubicin on Short-Term Survival of Mouse Mammary Tumor Cells","display_name":"Synergistic Effects of Ultrasound-Activated Microbubbles and Doxorubicin on Short-Term Survival of Mouse Mammary Tumor Cells","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2013807473","doi":"https://doi.org/10.1177/016173461203400102","mag":"2013807473","pmid":"https://pubmed.ncbi.nlm.nih.gov/22655488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3417718"},"language":"en","primary_location":{"id":"doi:10.1177/016173461203400102","doi":"https://doi.org/10.1177/016173461203400102","is_oa":false,"landing_page_url":"https://doi.org/10.1177/016173461203400102","pdf_url":null,"source":{"id":"https://openalex.org/S202027287","display_name":"Ultrasonic Imaging","issn_l":"0161-7346","issn":["0161-7346","1096-0910"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasonic Imaging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3417718","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011988565","display_name":"Goutam Ghoshal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Goutam Ghoshal","raw_affiliation_strings":["Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082973580","display_name":"Stanley A. Swat","orcid":"https://orcid.org/0000-0002-3736-7434","observed_orcids":["https://orcid.org/0000-0002-3736-7434"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stanley Swat","raw_affiliation_strings":["Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004000426","display_name":"Michael L. Oelze","orcid":"https://orcid.org/0000-0002-3099-7425","observed_orcids":["https://orcid.org/0000-0002-3099-7425"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael L. Oelze","raw_affiliation_strings":["Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioacoustics Research Laboratory Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign 405 North Mathews Urbana, IL 61801","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004000426","https://openalex.org/A5011988565","https://openalex.org/A5082973580"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.8649,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7099341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"34","issue":"1","first_page":"15","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ultrasound-contrast-agents","display_name":"ultrasound contrast agents","score":0.8199999928474426},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5540000200271606},{"id":"https://openalex.org/keywords/synergistic-drug-delivery","display_name":"synergistic drug delivery","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.609000027179718},{"id":"https://openalex.org/keywords/sound-pressure","display_name":"acoustic pressure","score":0.6389999985694885},{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.9000959396362305},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8352105617523193},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.6956945061683655},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6580894589424133},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.49730756878852844},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48188692331314087},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44234219193458557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.418100506067276},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4037390351295471},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3852517902851105},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3392874002456665},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2977699935436249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28792184591293335},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27055007219314575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10880744457244873},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0763024389743805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06041783094406128}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/016173461203400102","doi":"https://doi.org/10.1177/016173461203400102","is_oa":false,"landing_page_url":"https://doi.org/10.1177/016173461203400102","pdf_url":null,"source":{"id":"https://openalex.org/S202027287","display_name":"Ultrasonic Imaging","issn_l":"0161-7346","issn":["0161-7346","1096-0910"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasonic Imaging","raw_type":"journal-article"},{"id":"pmid:22655488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22655488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasonic imaging","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2533199","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3417718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3417718","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3417718","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ultrason Imaging","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.682.3783","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.682.3783","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.brl.uiuc.edu/Publications/2012/Ghoshal-UltrasonImaging-15-2012.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2533199","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3417718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2102609980","display_name":"Use of quantitative ultrasound to stage, monitor, and assess HIFU treatment","funder_award_id":"R01EB008992","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6250795176","display_name":"Ultrasound-induced tissue damage assessment","funder_award_id":"R37EB002641","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W229473651","https://openalex.org/W1975071763","https://openalex.org/W1984833986","https://openalex.org/W1997892364","https://openalex.org/W2004512195","https://openalex.org/W2005089058","https://openalex.org/W2043902038","https://openalex.org/W2100044517","https://openalex.org/W2120284193","https://openalex.org/W2128002924","https://openalex.org/W2134139477","https://openalex.org/W2533166227"],"related_works":["https://openalex.org/W7095467701","https://openalex.org/W1970608501","https://openalex.org/W1995530661","https://openalex.org/W2596480745","https://openalex.org/W4291597111","https://openalex.org/W2533166227","https://openalex.org/W209384644","https://openalex.org/W2782992443","https://openalex.org/W2105114855","https://openalex.org/W2732968940"],"abstract_inverted_index":{"The":[0,37,99,134,155],"primary":[1],"focus":[2],"of":[3,72,81,101,126,142,185,192],"this":[4],"paper":[5],"is":[6],"to":[7,48,50,61,112,146],"quantify":[8],"the":[9,63,70,73,76,102,120,129,193],"therapeutic":[10],"synergism":[11],"when":[12,150,162],"combining":[13],"ultrasound,":[14],"ultrasound":[15,68,77,194],"contrast":[16],"agents":[17],"(UCAs)":[18],"and":[19,46,85,96,105],"doxorubicin":[20,82,152,186],"for":[21,87,182],"breast":[22],"cancer":[23],"treatment":[24,127],"using":[25,128],"an":[26],"in":[27,42,138,177,197],"vitro":[28],"experimental":[29],"configuration":[30],"with":[31,67,109,168],"mouse":[32],"mammary":[33],"tumor":[34],"(4T1)":[35],"cells.":[36,74],"4T1":[38],"cells":[39,114],"were":[40,83,115,166],"grown":[41],"96":[43],"well":[44],"plates":[45],"allowed":[47],"grow":[49],"90%":[51],"confluency.":[52],"A":[53],"1-MHz":[54],"focused":[55],"(f/3)":[56],"single-element":[57],"transducer":[58],"was":[59,153,158,180],"used":[60,167],"expose":[62],"microbubbles":[64],"(MBs)":[65],"(Definity)":[66],"near":[69],"surface":[71],"After":[75],"exposure,":[78],"different":[79],"doses":[80],"added":[84],"incubated":[86],"24":[88,124],"hours":[89,125],"at":[90],"37":[91],"degrees":[92],"C,":[93],"100%":[94],"humidity":[95],"5%":[97],"CO2.":[98],"efficacies":[100],"drug":[103,110],"only":[104,151,163],"ultrasound-activated":[106,164],"MBs":[107,165],"combined":[108,135],"therapies":[111],"kill":[113],"then":[116],"quantified":[117],"by":[118],"analyzing":[119],"cell":[121,143,156,178,199],"viability":[122,144,157],"after":[123],"MTT":[130],"Cell":[131],"Proliferation":[132],"Assay.":[133],"therapy":[136],"resulted":[137,196],"60":[139],"+/-":[140,148,160],"5.9%":[141],"compared":[145],"82":[147],"4.5%":[149],"used.":[154],"72":[159],"5.8%":[161],"a":[169],"similar":[170],"acoustic":[171],"pressure":[172,191],"condition.":[173],"No":[174],"significant":[175],"increase":[176],"death":[179],"observed":[181],"higher":[183,188],"concentrations":[184],"whereas":[187],"peak":[189],"negative":[190],"wave":[195],"increased":[198],"death.":[200]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}