{"id":"https://openalex.org/W2013804946","doi":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","title":"Structure and dynamics of polyunsaturated hydrocarbon chains in lipid bilayers\u2014significance for GPCR function","display_name":"Structure and dynamics of polyunsaturated hydrocarbon chains in lipid bilayers\u2014significance for GPCR function","publication_year":2008,"publication_date":"2008-04-08","ids":{"openalex":"https://openalex.org/W2013804946","doi":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","mag":"2013804946","pmid":"https://pubmed.ncbi.nlm.nih.gov/18396152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453513"},"language":"en","primary_location":{"id":"doi:10.1016/j.chemphyslip.2008.02.016","doi":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","pdf_url":null,"source":{"id":"https://openalex.org/S99078529","display_name":"Chemistry and Physics of Lipids","issn_l":"0009-3084","issn":["0009-3084","1873-2941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry and Physics of Lipids","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453513","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052880769","display_name":"Klaus Gawrisch","orcid":"https://orcid.org/0000-0002-0841-1539","observed_orcids":["https://orcid.org/0000-0002-0841-1539"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Klaus Gawrisch","raw_affiliation_strings":["Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States. klausg@mail.nih.gov","Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States. klausg@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]},{"raw_affiliation_string":"Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029711171","display_name":"Olivier Soubias","orcid":"https://orcid.org/0000-0003-4819-2753","observed_orcids":["https://orcid.org/0000-0003-4819-2753"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Soubias","raw_affiliation_strings":["Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of NMR, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052880769"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":0.4638,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.38348813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"153","issue":"1","first_page":"64","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.9010000228881836},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9269999861717224},{"id":"https://openalex.org/keywords/docosapentaenoic-acid","display_name":"docosapentaenoic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.7549999952316284},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-lipid-interactions","display_name":"protein-lipid interactions","score":0.6949999928474426},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.890999972820282},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":1.0},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.7749999761581421},{"id":"https://openalex.org/keywords/membrane-reconstitution","display_name":"membrane reconstitution","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.868657112121582},{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.8151454329490662},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5951046943664551},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5651946663856506},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.558857262134552},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5236461162567139},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5085395574569702},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.354921817779541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2924844026565552},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25003230571746826},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.07361790537834167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.chemphyslip.2008.02.016","doi":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.chemphyslip.2008.02.016","pdf_url":null,"source":{"id":"https://openalex.org/S99078529","display_name":"Chemistry and Physics of Lipids","issn_l":"0009-3084","issn":["0009-3084","1873-2941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry and Physics of Lipids","raw_type":"journal-article"},{"id":"pmid:18396152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18396152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry and physics of lipids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2453513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453513","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Phys Lipids","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2453513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453513","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Phys Lipids","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1997962874","display_name":null,"funder_award_id":"Z99\u2010AA999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5627291527","display_name":"NMR Investigations Of Cell Membrane Structure","funder_award_id":"Z01AA000003","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332178","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337575","display_name":"NIST Center for Neutron Research","ror":"https://ror.org/05qgcra83"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1482260509","https://openalex.org/W1541778702","https://openalex.org/W1568101544","https://openalex.org/W1967463479","https://openalex.org/W1972859890","https://openalex.org/W1976907613","https://openalex.org/W1981633834","https://openalex.org/W1986110489","https://openalex.org/W1986231122","https://openalex.org/W1991186550","https://openalex.org/W1995093903","https://openalex.org/W1996177794","https://openalex.org/W1997036377","https://openalex.org/W2002396116","https://openalex.org/W2007356066","https://openalex.org/W2008765490","https://openalex.org/W2011915654","https://openalex.org/W2013238661","https://openalex.org/W2015943547","https://openalex.org/W2021801729","https://openalex.org/W2022085679","https://openalex.org/W2023835074","https://openalex.org/W2024606771","https://openalex.org/W2025717854","https://openalex.org/W2029055984","https://openalex.org/W2030560811","https://openalex.org/W2038434242","https://openalex.org/W2048338470","https://openalex.org/W2048550135","https://openalex.org/W2051797258","https://openalex.org/W2052101194","https://openalex.org/W2060319658","https://openalex.org/W2062440712","https://openalex.org/W2068636421","https://openalex.org/W2072069399","https://openalex.org/W2074300576","https://openalex.org/W2076295231","https://openalex.org/W2078856946","https://openalex.org/W2079542227","https://openalex.org/W2080244677","https://openalex.org/W2081073926","https://openalex.org/W2083741754","https://openalex.org/W2085076225","https://openalex.org/W2090818352","https://openalex.org/W2120531334","https://openalex.org/W2164468002","https://openalex.org/W2171887514","https://openalex.org/W2338400093","https://openalex.org/W2470665661","https://openalex.org/W2480012695","https://openalex.org/W4249983668","https://openalex.org/W4255370921"],"related_works":["https://openalex.org/W2024943051","https://openalex.org/W2475302425","https://openalex.org/W2040396690","https://openalex.org/W1981633834","https://openalex.org/W3172350842","https://openalex.org/W2060319658","https://openalex.org/W2076295231","https://openalex.org/W2101016925","https://openalex.org/W3100190058","https://openalex.org/W2155584072"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}