{"id":"https://openalex.org/W2013802449","doi":"https://doi.org/10.1186/preaccept-1492846834139911","title":"Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission","display_name":"Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2013802449","doi":"https://doi.org/10.1186/preaccept-1492846834139911","mag":"2013802449","pmid":"https://pubmed.ncbi.nlm.nih.gov/25385196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4255442"},"language":"en","primary_location":{"id":"doi:10.1186/preaccept-1492846834139911","doi":"https://doi.org/10.1186/preaccept-1492846834139911","is_oa":true,"landing_page_url":"https://doi.org/10.1186/preaccept-1492846834139911","pdf_url":"https://bmcbiol.biomedcentral.com/track/pdf/10.1186/s12915-014-0092-2","source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbiol.biomedcentral.com/track/pdf/10.1186/s12915-014-0092-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050602124","display_name":"Danielle V. Bower","orcid":"https://orcid.org/0000-0002-4469-4855","observed_orcids":["https://orcid.org/0000-0002-4469-4855"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Danielle V Bower","raw_affiliation_strings":["Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","Division of Biological Sciences, California Institute of Technology, Pasadena, USA","The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Biological Sciences, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108565680","display_name":"Hyung-Kook Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyung-Kook Lee","raw_affiliation_strings":["Division of Biological Sciences, California Institute of Technology, Pasadena, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050597104","display_name":"Rusty D. Lansford","orcid":"https://orcid.org/0000-0002-2159-3699","observed_orcids":["https://orcid.org/0000-0002-2159-3699"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rusty Lansford","raw_affiliation_strings":["The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028206869","display_name":"Kai Zinn","orcid":"https://orcid.org/0000-0002-6706-5605","observed_orcids":["https://orcid.org/0000-0002-6706-5605"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Zinn","raw_affiliation_strings":["Division of Biological Sciences, California Institute of Technology, Pasadena, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108195880","display_name":"David Warburton","orcid":"https://orcid.org/0000-0002-4605-1298","observed_orcids":["https://orcid.org/0000-0002-4605-1298"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Warburton","raw_affiliation_strings":["The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047064481","display_name":"Scott E. Fraser","orcid":"https://orcid.org/0000-0002-5377-0223","observed_orcids":["https://orcid.org/0000-0002-5377-0223"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E Fraser","raw_affiliation_strings":["Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","Biological Sciences and Biomedical Engineering, University of Southern California, Los Angeles, USA","Division of Biological Sciences, California Institute of Technology, Pasadena, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Biological Sciences and Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Division of Biological Sciences, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088826710","display_name":"Edwin C. Jesudason","orcid":"https://orcid.org/0000-0001-7855-2030","observed_orcids":["https://orcid.org/0000-0001-7855-2030"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]},{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4405270452","display_name":"Saban Research Institute","ror":"https://ror.org/00qe7sv26","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405270452"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Edwin C Jesudason","raw_affiliation_strings":["Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","Division of Biological Sciences, California Institute of Technology, Pasadena, USA","Division of Child Health, University of Liverpool, Liverpool, UK","The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Imaging Center, California Institute of Technology, 1200 E. California Blvd, MC 139-74, Pasadena, 91125, CA, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Biological Sciences, California Institute of Technology, Pasadena, USA","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Child Health, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"The Saban Research Institute, Children\u2019s Hospital Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I1336910626","https://openalex.org/I4405270452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5050602124","https://openalex.org/A5088826710"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I1336910626","https://openalex.org/I146655781","https://openalex.org/I4405270452"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.3661,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.79234897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"92","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-branching","display_name":"airway branching","score":0.9700000286102295},{"id":"https://openalex.org/keywords/parasympathetic-innervation","display_name":"parasympathetic innervation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.921999990940094},{"id":"https://openalex.org/keywords/lung-morphogenesis","display_name":"lung morphogenesis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/drosophila-embryo","display_name":"Drosophila embryo","score":0.7319999933242798},{"id":"https://openalex.org/keywords/laser-ablation","display_name":"laser ablation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.6850000023841858},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/vasculature","display_name":"vascular system","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8817901611328125},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6644973754882812},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.634361743927002},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5887110829353333},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4559304416179657},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42412269115448},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3024146258831024},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007448","descriptor_name":"Invertebrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014714","descriptor_name":"Vertebrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/preaccept-1492846834139911","doi":"https://doi.org/10.1186/preaccept-1492846834139911","is_oa":true,"landing_page_url":"https://doi.org/10.1186/preaccept-1492846834139911","pdf_url":"https://bmcbiol.biomedcentral.com/track/pdf/10.1186/s12915-014-0092-2","source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},{"id":"doi:10.1186/s12915-014-0092-2","doi":"https://doi.org/10.1186/s12915-014-0092-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-014-0092-2","pdf_url":"https://bmcbiol.biomedcentral.com/counter/pdf/10.1186/s12915-014-0092-2","source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4255442","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4255442","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biol","raw_type":"Text"},{"id":"pmid:25385196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25385196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC biology","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:53257","doi":null,"is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20150107-092653170","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/preaccept-1492846834139911","doi":"https://doi.org/10.1186/preaccept-1492846834139911","is_oa":true,"landing_page_url":"https://doi.org/10.1186/preaccept-1492846834139911","pdf_url":"https://bmcbiol.biomedcentral.com/track/pdf/10.1186/s12915-014-0092-2","source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5103471264","display_name":"Functional analysis of neural crest & palate: Imaging craniofacial development","funder_award_id":"U01DE020063","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6265861212","display_name":"Deciphering the Dynamics of Lung Development and the Role of Neural Input","funder_award_id":"F30HL110723","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309100","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95"},{"id":"https://openalex.org/F4320310870","display_name":"American Asthma Foundation","ror":"https://ror.org/05f6w6d75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013802449.pdf","grobid_xml":"https://content.openalex.org/works/W2013802449.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1591491361","https://openalex.org/W1603257718","https://openalex.org/W1976835478","https://openalex.org/W1982517873","https://openalex.org/W1999250936","https://openalex.org/W2005215351","https://openalex.org/W2011850350","https://openalex.org/W2013161210","https://openalex.org/W2015607265","https://openalex.org/W2049959255","https://openalex.org/W2052316245","https://openalex.org/W2052350776","https://openalex.org/W2084691474","https://openalex.org/W2084707443","https://openalex.org/W2085826865","https://openalex.org/W2086200882","https://openalex.org/W2095247200","https://openalex.org/W2106741522","https://openalex.org/W2125216271","https://openalex.org/W2143498768","https://openalex.org/W2149918754","https://openalex.org/W2161788184","https://openalex.org/W2163847509","https://openalex.org/W2166572577","https://openalex.org/W2747915831","https://openalex.org/W4211072041"],"related_works":["https://openalex.org/W2025693964","https://openalex.org/W2013660177","https://openalex.org/W2014177624","https://openalex.org/W2144425100","https://openalex.org/W2133797128","https://openalex.org/W1769099067","https://openalex.org/W2183875044","https://openalex.org/W1979088361","https://openalex.org/W2435824850","https://openalex.org/W2060517794"],"abstract_inverted_index":{"BACKGROUND:":[0],"Parasympathetic":[1],"signaling":[2],"has":[3],"been":[4],"inferred":[5],"to":[6,37,86,114,227],"regulate":[7],"epithelial":[8,110,170,210],"branching":[9,115,127,173],"as":[10,12],"well":[11],"organ":[13],"regeneration":[14],"and":[15,109,192,209],"tumor":[16],"development.":[17,157],"However,":[18],"the":[19,56,87,117,120,142,150,164,204,221],"relative":[20],"contribution":[21],"of":[22,139,166,224],"local":[23,42,188,222],"nerve":[24],"contact":[25],"versus":[26],"secreted":[27],"signals":[28],"remains":[29],"unclear.":[30],"Here,":[31],"we":[32],"show":[33],"a":[34,68,167],"conserved":[35],"(vertebrates":[36],"invertebrates)":[38],"requirement":[39],"for":[40,125,200],"intact":[41],"nerves":[43,124],"in":[44,116,133,141,163,190,203],"airway":[45,126,156,172,185],"branching,":[46],"persisting":[47],"even":[48,162],"when":[49],"cholinergic":[50,95],"neurotransmission":[51,195],"is":[52,79,174,196],"blocked.":[53],"RESULTS:":[54],"In":[55],"vertebrate":[57,118],"lung,":[58,119],"deleting":[59,131],"enhanced":[60],"green":[61],"fluorescent":[62],"protein":[63],"(eGFP)-labeled":[64],"intrinsic":[65],"neurons":[66,132,140],"using":[67],"two-photon":[69],"laser":[70,83,217],"leaves":[71],"adjacent":[72,89,107,207],"cells":[73],"intact,":[74],"but":[75],"abolishes":[76],"branching.":[77],"Branching":[78],"unaffected":[80],"by":[81,93,98,130,145,177],"similar":[82],"power":[84],"delivered":[85],"immediately":[88],"non-neural":[90],"mesodermal":[91],"tissue,":[92],"blocking":[94,99],"receptors":[96],"or":[97,169],"synaptic":[100],"transmission":[101],"with":[102],"botulinum":[103],"toxin":[104],"A.":[105],"Because":[106],"vasculature":[108,168,208],"proliferation":[111,211],"also":[112],"contribute":[113],"direct":[121],"dependence":[122],"on":[123],"was":[128],"tested":[129],"Drosophila":[134,143,155],"embryos.":[135],"A":[136],"specific":[137],"deletion":[138],"embryo":[144],"driving":[146],"cell-autonomous":[147],"RicinA":[148],"under":[149],"pan-neuronal":[151],"elav":[152],"enhancer":[153],"perturbed":[154],"This":[158],"system":[159],"confirmed":[160],"that":[161,184],"absence":[165],"proliferation,":[171],"still":[175],"disrupted":[176],"neural":[178],"lesioning.":[179],"CONCLUSIONS:":[180],"Together,":[181],"this":[182],"shows":[183],"morphogenesis":[186],"requires":[187],"innervation":[189,201,226],"vertebrates":[191],"invertebrates,":[193],"yet":[194],"dispensable.":[197],"The":[198],"need":[199],"persists":[202],"fly,":[205],"wherein":[206],"are":[212],"absent.":[213],"Our":[214],"novel,":[215],"targeted":[216],"ablation":[218],"technique":[219],"permitted":[220],"function":[223],"parasympathetic":[225],"be":[228],"distinguished":[229],"from":[230],"neurotransmission.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}