{"id":"https://openalex.org/W2013802173","doi":"https://doi.org/10.1016/s0306-4522(02)00869-2","title":"Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin","display_name":"Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin","publication_year":2003,"publication_date":"2003-06-21","ids":{"openalex":"https://openalex.org/W2013802173","doi":"https://doi.org/10.1016/s0306-4522(02)00869-2","mag":"2013802173","pmid":"https://pubmed.ncbi.nlm.nih.gov/12809692"},"language":"en","primary_location":{"id":"doi:10.1016/s0306-4522(02)00869-2","doi":"https://doi.org/10.1016/s0306-4522(02)00869-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-4522(02)00869-2","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024895209","display_name":"Kanishka N. Nilaweera","orcid":"https://orcid.org/0000-0002-6074-9457","observed_orcids":["https://orcid.org/0000-0002-6074-9457"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.N Nilaweera","raw_affiliation_strings":["Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, AB21 9SB, Scotland, Bucksburn, Aberdeen, UK","Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, AB21 9SB, Scotland, Bucksburn, Aberdeen, UK","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074280752","display_name":"Perry Barrett","orcid":"https://orcid.org/0000-0003-3604-2950","observed_orcids":["https://orcid.org/0000-0003-3604-2950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Barrett","raw_affiliation_strings":["Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054800715","display_name":"Julian G. Mercer","orcid":"https://orcid.org/0000-0001-8070-2886","observed_orcids":["https://orcid.org/0000-0001-8070-2886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.G Mercer","raw_affiliation_strings":["Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089854237","display_name":"Peter J. Morgan","orcid":"https://orcid.org/0000-0002-5071-6512","observed_orcids":["https://orcid.org/0000-0002-5071-6512"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P.J Morgan","raw_affiliation_strings":["Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuroendocrinology Group, Rowett Research Institute, Aberdeen Centre for Energy Regulation and Obesity (ACERO), Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089854237"],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.2483,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.76133909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"119","issue":"3","first_page":"713","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pc1","display_name":"PC1","score":0.527999997138977},{"id":"https://openalex.org/keywords/pc2","display_name":"PC2","score":0.968999981880188},{"id":"https://openalex.org/keywords/pace4","display_name":"PACE4","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.8410000205039978},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/negative-energy-balance","display_name":"negative energy balance","score":0.796999990940094},{"id":"https://openalex.org/keywords/food-deprivation","display_name":"food deprivation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/prepro-orexin","display_name":"prepro-orexin","score":0.8769999742507935},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.6909999847412109},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.921999990940094},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus","display_name":"ventromedial hypothalamus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.825000524520874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8059882521629333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7991640567779541},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7875510454177856},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7390289902687073},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.6557406187057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5686928033828735},{"id":"https://openalex.org/C2776046087","wikidata":"https://www.wikidata.org/wiki/Q7920337","display_name":"Ventromedial nucleus of the hypothalamus","level":3,"score":0.5648836493492126},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5017657279968262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30928200483322144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1678147315979004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11331945657730103},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.07424470782279968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0718957781791687}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043484","descriptor_name":"Proprotein Convertases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045664","descriptor_name":"Proprotein Convertase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0306-4522(02)00869-2","doi":"https://doi.org/10.1016/s0306-4522(02)00869-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0306-4522(02)00869-2","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:12809692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12809692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1503569939","https://openalex.org/W1512050447","https://openalex.org/W1595497744","https://openalex.org/W1605379658","https://openalex.org/W1688441846","https://openalex.org/W1965574341","https://openalex.org/W1973738370","https://openalex.org/W1974570654","https://openalex.org/W1976027570","https://openalex.org/W1990179777","https://openalex.org/W1993811128","https://openalex.org/W1995262493","https://openalex.org/W1996713062","https://openalex.org/W2002651835","https://openalex.org/W2005409308","https://openalex.org/W2011479605","https://openalex.org/W2027740042","https://openalex.org/W2031196190","https://openalex.org/W2041677480","https://openalex.org/W2051713176","https://openalex.org/W2052972724","https://openalex.org/W2054428747","https://openalex.org/W2062808764","https://openalex.org/W2065145318","https://openalex.org/W2066330288","https://openalex.org/W2119483052","https://openalex.org/W2121093397","https://openalex.org/W2148685859","https://openalex.org/W2150862512","https://openalex.org/W2266583237","https://openalex.org/W2334061140","https://openalex.org/W2410410534","https://openalex.org/W4241336870"],"related_works":["https://openalex.org/W2001196812","https://openalex.org/W2052912427","https://openalex.org/W2016261339","https://openalex.org/W2048160943","https://openalex.org/W2011479605","https://openalex.org/W7098635181","https://openalex.org/W2145354869","https://openalex.org/W2041039203","https://openalex.org/W1974570654","https://openalex.org/W2064342369"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
