{"id":"https://openalex.org/W2013799653","doi":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","title":"Glucocorticoids, tumor necrosis factor-\u03b1, and epidermal growth factor regulation of pulmonary morphogenesis: a multivariate in vitro analysis of their related actions","display_name":"Glucocorticoids, tumor necrosis factor-\u03b1, and epidermal growth factor regulation of pulmonary morphogenesis: a multivariate in vitro analysis of their related actions","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W2013799653","doi":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","mag":"2013799653","pmid":"https://pubmed.ncbi.nlm.nih.gov/8901048"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087921962","display_name":"Michael Melnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Melnick","raw_affiliation_strings":["Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089-0641, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089-0641, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054766979","display_name":"Henry A. Choy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry A. Choy","raw_affiliation_strings":["Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089-0641"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089-0641","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037656968","display_name":"Tina F. Jaskoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Jaskoll","raw_affiliation_strings":["Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089-0641"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089-0641","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087921962"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":5.2499,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.95202584,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"205","issue":"4","first_page":"365","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/branching-morphogenesis","display_name":"branching morphogenesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-interactions","display_name":"epithelial-mesenchymal interactions","score":0.9049999713897705},{"id":"https://openalex.org/keywords/surfactant-protein-a","display_name":"surfactant protein A","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tgfbeta3","display_name":"TGF-beta3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lung-maturation","display_name":"lung maturation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/fractal-dimension","display_name":"fractal dimension","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8819974660873413},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7921844720840454},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.7041873335838318},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6447261571884155},{"id":"https://openalex.org/C146759223","wikidata":"https://www.wikidata.org/wiki/Q17927902","display_name":"FGF10","level":4,"score":0.629108190536499},{"id":"https://openalex.org/C184750944","wikidata":"https://www.wikidata.org/wiki/Q557677","display_name":"Primordium","level":3,"score":0.6272814273834229},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6268614530563354},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4957190752029419},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4328667223453522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42550987005233765},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.419320285320282},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.41165679693222046},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32332420349121094},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2486298680305481},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23173832893371582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1256086826324463},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11289742588996887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","doi":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.3.co;2-3","doi":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.3.co;2-3","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0177(199604)205:4<365::aid-aja1>3.3.co;2-3","pdf_url":null,"source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:8901048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W103972844","https://openalex.org/W107992251","https://openalex.org/W1007996579","https://openalex.org/W1520486961","https://openalex.org/W1528255535","https://openalex.org/W1570009092","https://openalex.org/W1602650573","https://openalex.org/W1608791497","https://openalex.org/W1966199522","https://openalex.org/W1968654392","https://openalex.org/W1971477275","https://openalex.org/W1977943592","https://openalex.org/W1978759628","https://openalex.org/W1980047041","https://openalex.org/W1985400766","https://openalex.org/W1992417191","https://openalex.org/W1993821331","https://openalex.org/W2003149418","https://openalex.org/W2011938900","https://openalex.org/W2016434419","https://openalex.org/W2017068777","https://openalex.org/W2020977918","https://openalex.org/W2027334097","https://openalex.org/W2030990943","https://openalex.org/W2052485716","https://openalex.org/W2055305108","https://openalex.org/W2055741808","https://openalex.org/W2057594692","https://openalex.org/W2057819810","https://openalex.org/W2064212602","https://openalex.org/W2073092491","https://openalex.org/W2073800150","https://openalex.org/W2075092699","https://openalex.org/W2075279878","https://openalex.org/W2076251639","https://openalex.org/W2076731491","https://openalex.org/W2078206416","https://openalex.org/W2080036508","https://openalex.org/W2081469714","https://openalex.org/W2084269219","https://openalex.org/W2092181888","https://openalex.org/W2092764056","https://openalex.org/W2103186659","https://openalex.org/W2134812217","https://openalex.org/W2159774166","https://openalex.org/W2172193595","https://openalex.org/W2181382912","https://openalex.org/W2283610042","https://openalex.org/W2340164120","https://openalex.org/W2416988240","https://openalex.org/W2417666744","https://openalex.org/W2425350825","https://openalex.org/W2491859759","https://openalex.org/W2800860906","https://openalex.org/W4250894260","https://openalex.org/W4294216491","https://openalex.org/W6723064746"],"related_works":["https://openalex.org/W2052485716","https://openalex.org/W2014826469","https://openalex.org/W2006928934","https://openalex.org/W1977494678","https://openalex.org/W2037466018","https://openalex.org/W2122124110","https://openalex.org/W2313085709","https://openalex.org/W2418603444","https://openalex.org/W2081845788","https://openalex.org/W2004545713"],"abstract_inverted_index":{"The":[0],"mouse":[1],"lung":[2,27,105,136,216,223,275],"commences":[3],"development":[4],"on":[5,150,157,186],"embryonic":[6,104,135,173],"day":[7,158],"11":[8],"as":[9,31,33,85],"an":[10,226],"epithelial":[11],"evagination":[12],"from":[13],"the":[14,26,113,167,195,273,280],"posterior":[15],"pharyngeal":[16],"wall":[17],"into":[18,225],"undifferentiated":[19],"mesenchyme,":[20],"this":[21,57],"epithelium":[22,217],"bifurcating":[23],"to":[24,51,67,88,172,190,264],"form":[25],"primordium.":[28],"Branching":[29],"morphogenesis,":[30,128],"well":[32],"terminal":[34,212],"differentiation,":[35],"requires":[36],"epithelial-mesenchymal":[37],"interactions":[38],"utilizing":[39],"precise":[40],"regulatory":[41,294],"controls.":[42],"Not":[43],"surprisingly,":[44],"specific":[45],"hormones":[46],"and":[47,75,78,82,95,121,183,218,243,259],"growth":[48,92],"factors":[49],"appear":[50,189],"play":[52],"a":[53,62,219,235,257,287],"key":[54],"role":[55],"in":[56,103,112,134,155,279],"regulation.":[58],"We":[59],"report":[60],"here":[61],"series":[63],"of":[64,91,115,169,197,214,222,240,282],"experiments":[65,100],"designed":[66],"investigate":[68],"morphodifferentiation":[69,182,192],"(epithelial":[70],"branching":[71,127,148],"number,":[72,74],"generation":[73],"fractal":[76],"dimension)":[77],"histodifferentiation":[79],"(cell":[80],"morphology":[81],"SP-A":[83,132,160,203,260],"immunolocalization),":[84],"they":[86],"relate":[87],"glucocorticoid":[89],"(CORT)-regulation":[90],"factor":[93],"function":[94],"expression":[96,161,261],"(Northern":[97],"analysis).":[98],"These":[99],"were":[101],"conducted":[102],"primordia":[106,137],"(E11.5-E12)":[107],"cultured":[108,138,175],"under":[109],"defined":[110],"conditions":[111],"presence":[114,281],"single":[116],"or":[117,141,153,177,253],"combined":[118],"CORT,":[119],"TNF-alpha,":[120],"EGF":[122,124,271],"supplementation.":[123],"supplementation":[125,145,269],"enhances":[126,147],"but":[129],"not":[130],"immunodetectable":[131],"expression,":[133],"for":[139],"4":[140,152,176],"7":[142,154,178],"days.":[143],"TNF-alpha":[144,252,284],"also":[146,163],"morphogenesis":[149,209],"days":[151,179],"vitro;":[156],"7,":[159],"is":[162,232],"enhanced.":[164],"By":[165],"contrast,":[166],"introduction":[168],"exogenous":[170,283],"CORT":[171,250,254,268],"explants":[174],"markedly":[180],"alters":[181,208],"histodifferentiation.":[184],"Early":[185],"it":[187,207],"would":[188],"enhance":[191],"by":[193,210],"changing":[194],"process":[196],"branching,":[198],"while":[199],"contemporaneously":[200],"initiating":[201],"precocious":[202],"expression;":[204],"later":[205],"on,":[206],"continued":[211],"differentiation":[213],"normal":[215],"singular":[220],"transdifferentiation":[221],"mesenchyme":[224],"epithelioid":[227],"morphotype":[228],"expressing":[229],"SP-A.":[230],"This":[231],"correlated":[233],"with":[234,249,267],"CORT-induced,":[236],"highly":[237],"significant,":[238],"down-regulation":[239],"TGF-beta":[241,244],"2":[242],"3":[245],"transcripts.":[246],"Explants":[247],"supplemented":[248],"+":[251,255],"EGF.demonstrate":[256],"microanatomy":[258],"pattern":[262],"identical":[263],"that":[265],"seen":[266,278],"alone.":[270],"inhibits":[272],"accelerated":[274],"maturation":[276],"normally":[277],"alone,":[285],"suggesting":[286],"relationship":[288],"between":[289],"these":[290],"two":[291],"seemingly":[292],"disparate":[293],"pathways.":[295]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
