{"id":"https://openalex.org/W2013771465","doi":"https://doi.org/10.1074/jbc.m309978200","title":"Trypanosoma brucei Plasma Membrane-Type Ca2+-ATPase 1 (TbPMC1) and 2 (TbPMC2) Genes Encode Functional Ca2+-ATPases Localized to the Acidocalcisomes and Plasma Membrane, and Essential for Ca2+ Homeostasis and Growth","display_name":"Trypanosoma brucei Plasma Membrane-Type Ca2+-ATPase 1 (TbPMC1) and 2 (TbPMC2) Genes Encode Functional Ca2+-ATPases Localized to the Acidocalcisomes and Plasma Membrane, and Essential for Ca2+ Homeostasis and Growth","publication_year":2004,"publication_date":"2004-03-26","ids":{"openalex":"https://openalex.org/W2013771465","doi":"https://doi.org/10.1074/jbc.m309978200","mag":"2013771465","pmid":"https://pubmed.ncbi.nlm.nih.gov/14724285"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m309978200","doi":"https://doi.org/10.1074/jbc.m309978200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309978200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m309978200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101915487","display_name":"Shuhong Luo","orcid":"https://orcid.org/0000-0002-9058-4833","observed_orcids":["https://orcid.org/0000-0002-9058-4833"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuhong Luo","raw_affiliation_strings":["Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA","Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008889924","display_name":"Peter J Rohloff","orcid":"https://orcid.org/0000-0001-7274-8315","observed_orcids":["https://orcid.org/0000-0001-7274-8315"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Rohloff","raw_affiliation_strings":["Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045477130","display_name":"Joanna M. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Cox","raw_affiliation_strings":["Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036138078","display_name":"S\u00e9rgio Akira Uyemura","orcid":"https://orcid.org/0000-0001-5505-9817","observed_orcids":["https://orcid.org/0000-0001-5505-9817"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio A. Uyemura","raw_affiliation_strings":["Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Parasitology, Department of Pathobiology, and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000842323"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.6672,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.88812401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"279","issue":"14","first_page":"14427","last_page":"14439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":1.0},{"id":"https://openalex.org/keywords/plasma-membrane-ca2-atpase","display_name":"plasma membrane Ca2+-ATPase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acidocalcisomes","display_name":"acidocalcisomes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vacuolar-h-pyrophosphatase","display_name":"vacuolar H+-pyrophosphatase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5860000252723694},{"id":"https://openalex.org/keywords/procyclic-forms","display_name":"procyclic forms","score":0.7269999980926514},{"id":"https://openalex.org/keywords/bloodstream-trypomastigotes","display_name":"bloodstream trypomastigotes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.828000009059906},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.8040000200271606},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.47099998593330383},{"id":"https://openalex.org/keywords/human-african-trypanosomiasis","display_name":"sleeping sickness","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.7804282307624817},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.6821369528770447},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5392946004867554},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.508553147315979},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5073270201683044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49898338317871094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43429073691368103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3587570786476135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28025785088539124},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14686855673789978}],"mesh":[{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025262","descriptor_name":"Vacuolar Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m309978200","doi":"https://doi.org/10.1074/jbc.m309978200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309978200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:14724285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14724285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m309978200","doi":"https://doi.org/10.1074/jbc.m309978200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m309978200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W70041852","https://openalex.org/W91167684","https://openalex.org/W95752452","https://openalex.org/W1509839595","https://openalex.org/W1584087556","https://openalex.org/W1635197759","https://openalex.org/W1774442194","https://openalex.org/W1966529677","https://openalex.org/W1967872268","https://openalex.org/W1969600436","https://openalex.org/W1973767731","https://openalex.org/W1975304761","https://openalex.org/W1982024087","https://openalex.org/W1984829055","https://openalex.org/W1986431188","https://openalex.org/W1992794819","https://openalex.org/W1994791448","https://openalex.org/W1995467090","https://openalex.org/W1997694813","https://openalex.org/W2000678289","https://openalex.org/W2012349421","https://openalex.org/W2014565441","https://openalex.org/W2022933506","https://openalex.org/W2033721665","https://openalex.org/W2036780183","https://openalex.org/W2046435945","https://openalex.org/W2062654610","https://openalex.org/W2067999317","https://openalex.org/W2086660631","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2106882534","https://openalex.org/W2108367015","https://openalex.org/W2108388593","https://openalex.org/W2109635696","https://openalex.org/W2115929745","https://openalex.org/W2116350092","https://openalex.org/W2120701106","https://openalex.org/W2138270253","https://openalex.org/W2144550154","https://openalex.org/W2144634347","https://openalex.org/W2153992958","https://openalex.org/W2157236463","https://openalex.org/W2159146740","https://openalex.org/W2172712627","https://openalex.org/W2176061808","https://openalex.org/W2314225431","https://openalex.org/W2328789677","https://openalex.org/W2411681746","https://openalex.org/W4247632830"],"related_works":["https://openalex.org/W1509839595","https://openalex.org/W2074468064","https://openalex.org/W2328789677","https://openalex.org/W1508527953","https://openalex.org/W2588219335","https://openalex.org/W2159146740","https://openalex.org/W1995457688","https://openalex.org/W2115929745","https://openalex.org/W2038119705","https://openalex.org/W2080525960"],"abstract_inverted_index":{"Trypanosoma":[0],"brucei":[1,119,207],"adaptation":[2],"and":[3,27,33,56,83,90,98,153,155,170,191,214],"survival":[4],"in":[5,18,114],"its":[6],"host":[7],"involve":[8],"integrated":[9],"regulation":[10],"of":[11,29,40,45,104,107,163,173,177,188,194],"Ca(2+)":[12,102,116,190,195],"pumps":[13],"(Ca(2+)-ATPases),":[14],"which":[15],"are":[16,92,209],"essential":[17,210],"calcium":[19],"ion":[20],"homeostasis.":[21],"Here":[22],"we":[23],"report":[24],"the":[25,54,69,73,79,101,148],"cloning":[26],"sequencing":[28],"two":[30],"genes":[31,121],"(TbPMC1":[32],"TbPMC2)":[34],"encoding":[35],"plasma":[36,80],"membrane-type":[37],"Ca(2+)-ATPases":[38],"(PMCAs)":[39],"T.":[41,118,206],"brucei,":[42],"an":[43],"agent":[44],"African":[46],"trypanosomiasis.":[47],"Indirect":[48],"immunofluorescence":[49],"analysis":[50],"using":[51,126],"antibodies":[52],"against":[53,57,179,183],"proteins":[55],"epitope":[58],"tags":[59],"introduced":[60],"into":[61],"each":[62],"protein":[63,156],"showed":[64],"that":[65,88,110,147,205],"TbPMC1":[66,89,97,180],"co-localized":[67],"with":[68,142,159],"vacuolar":[70,115],"H(+)-pyrophosphatase":[71],"to":[72,78,132],"acidocalcisomes":[74],"while":[75],"TbPMC2":[76,91,99,184],"localized":[77],"membrane.":[81],"Northern":[82],"Western":[84],"blot":[85],"analyses":[86],"revealed":[87],"up-regulated":[93],"during":[94],"blood":[95],"stages.":[96],"suppressed":[100],"hypersensitivity":[103],"a":[105,112],"mutant":[106],"S.":[108],"cerevisiae":[109],"has":[111],"defect":[113],"accumulation.":[117],"Ca(2+)-ATPase":[120],"were":[122,140],"functionally":[123],"characterized":[124],"by":[125],"double-stranded":[127],"RNA":[128],"interference":[129],"(RNAi)":[130,165],"methodology":[131],"produce":[133],"inducible":[134],"Ca(2+)-ATPase-deficient":[135],"procyclic":[136,174],"forms.":[137,175],"Similar":[138],"results":[139,203],"obtained":[141],"bloodstream":[143],"form":[144],"trypomastigotes,":[145],"except":[146],"RNAi":[149,178],"system":[150],"was":[151],"leaky":[152],"mRNA":[154],"levels":[157,187],"recovered":[158],"time.":[160],"The":[161],"induction":[162],"dsRNA":[164],"caused":[166,185],"gross":[167],"morphological":[168],"alterations,":[169],"growth":[171],"inhibition":[172],"Induction":[176],"but":[181],"not":[182],"elevated":[186],"cytosolic":[189],"decreased":[192],"mobilization":[193],"from":[196],"intracellular":[197],"stores":[198],"following":[199],"ionophore":[200],"addition.":[201],"These":[202],"establish":[204],"PMCA-Ca(2+)-ATPases":[208],"for":[211,219],"parasite":[212],"viability":[213],"validate":[215],"them":[216],"as":[217],"targets":[218],"drug":[220],"development.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
