{"id":"https://openalex.org/W2013769987","doi":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","title":"THE SELECTIVE ACTION OF \u03b2\u2010ADRENOCEPTOR BLOCKING DRUGS AND THE NATURE OF \u03b21 and \u03b22 ADRENOCEPTORS","display_name":"THE SELECTIVE ACTION OF \u03b2\u2010ADRENOCEPTOR BLOCKING DRUGS AND THE NATURE OF \u03b21 and \u03b22 ADRENOCEPTORS","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2013769987","doi":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","mag":"2013769987","pmid":"https://pubmed.ncbi.nlm.nih.gov/13902","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1667712"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1977.tb06980.x","doi":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1977.tb06980.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1977.tb06980.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113555443","display_name":"A.J. COLEMAN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.J. COLEMAN","raw_affiliation_strings":["Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113498925","display_name":"A. R. Somerville","orcid":"https://orcid.org/0000-0003-4250-4998","observed_orcids":["https://orcid.org/0000-0003-4250-4998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.R. SOMERVILLE","raw_affiliation_strings":["Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.1514,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.87278921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"1","first_page":"83","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta1-adrenergic-receptor","display_name":"beta1-adrenergic receptor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":1.0},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.7770000100135803},{"id":"https://openalex.org/keywords/practolol","display_name":"practolol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":1.0},{"id":"https://openalex.org/keywords/cardioselectivity","display_name":"cardioselectivity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/schild-plot","display_name":"Schild plot","score":0.6909999847412109},{"id":"https://openalex.org/keywords/beta-adrenergic-agonists","display_name":"beta-adrenergic agonists","score":0.6880000233650208},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.7630000114440918},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.7310000061988831},{"id":"https://openalex.org/keywords/syrosingopine","display_name":"syrosingopine","score":0.8149999976158142},{"id":"https://openalex.org/keywords/uterus","display_name":"uterus","score":0.4009999930858612},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2776663762","wikidata":"https://www.wikidata.org/wiki/Q7237376","display_name":"Practolol","level":3,"score":0.9733991026878357},{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.8879247903823853},{"id":"https://openalex.org/C75214554","wikidata":"https://www.wikidata.org/wiki/Q2235423","display_name":"Schild regression","level":4,"score":0.6973702311515808},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6850688457489014},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.6574974060058594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6348124146461487},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.6346368789672852},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5857052803039551},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.5774313807487488},{"id":"https://openalex.org/C2780275434","wikidata":"https://www.wikidata.org/wiki/Q201370","display_name":"Alprenolol","level":3,"score":0.526107132434845},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.4580906331539154},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4474669098854065},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.4385485053062439},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.363857239484787},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.23369577527046204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21622949838638306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18480512499809265},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002369","descriptor_name":"Castration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009708","descriptor_name":"Nucleotidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011217","descriptor_name":"Practolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1977.tb06980.x","doi":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1977.tb06980.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1667712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1667712","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:13902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1977.tb06980.x","doi":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1977.tb06980.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1977.tb06980.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013769987.pdf","grobid_xml":"https://content.openalex.org/works/W2013769987.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W45574617","https://openalex.org/W1775749144","https://openalex.org/W1986472994","https://openalex.org/W1989988736","https://openalex.org/W1996972993","https://openalex.org/W2006312580","https://openalex.org/W2020540326","https://openalex.org/W2034035686","https://openalex.org/W2034719362","https://openalex.org/W2085121246","https://openalex.org/W2141804782","https://openalex.org/W2165565144","https://openalex.org/W2223932543","https://openalex.org/W2253845483","https://openalex.org/W2309241413","https://openalex.org/W3022847910","https://openalex.org/W4407041229"],"related_works":["https://openalex.org/W2020540326","https://openalex.org/W2412892454","https://openalex.org/W2048663647","https://openalex.org/W1486608945","https://openalex.org/W163837500","https://openalex.org/W2013604813","https://openalex.org/W2002491445","https://openalex.org/W2013932679","https://openalex.org/W2046816891","https://openalex.org/W2013475109"],"abstract_inverted_index":{"1":[0],"Purified":[1],"membranes":[2,26],"retaining":[3],"a":[4,114,171,181],"catecholamine":[5],"responsive":[6],"adenylate":[7,56,195],"cyclase":[8,57,196,242],"have":[9,21,88],"prepared":[10,284,300],"from":[11,186,285,301],"rabbit":[12],"heart,":[13],"lung":[14,31,112,287,303],"and":[15,27,30,70,83,111,135,148,153,206,235,250,272],"(pseudo-pregnant)":[16],"uterus.":[17],"2":[18],"These":[19],"preparations":[20,202],"the":[22,37,55,66,123,166,187,215,230,240,255,260,269,277,293,313],"characteristics":[23],"of":[24,54,65,77,98,128,151,165,184,203,233,276,292,315],"plasma":[25],"both":[28],"heart":[29,110,249],"respond":[32],"to":[33,58,122],"beta-adrenoceptor":[34,59,80,86],"agonists":[35],"in":[36,198,222,259],"order:":[38],"(+/-)-isoprenaline":[39],"greater":[40,43,46,49],"than":[41,44,47,50,178,219],"(-)-noradrenaline":[42],"(-)-adrenaline":[45],"(+)-isoprenaline":[48],"salbutamol.":[51],"The":[52,126,156,226],"sensitivity":[53],"stimulation":[60,197],"is":[61,237,267],"improved":[62],"by":[63,168,193],"pre-treatment":[64],"animals":[67],"with":[68,113,140,174],"reserpine":[69],"syrosingopine.":[71],"3":[72],"Dose-ratios":[73],"for":[74,109,118,133,137,162],"several":[75],"concentrations":[76],"propranolol":[78,119],"(non-selective":[79],"blocker),":[81],"practolol":[82,134,169,234],"atenolol":[84,138,236],"(cardio-selective":[85],"blockers)":[87],"been":[89],"measured":[90],"on":[91,145],"all":[92],"three":[93],"membrane":[94,216],"preparations.":[95],"Schild":[96,172],"plots":[97],"log":[99,104],"(dose":[100],"ratio":[101,127,159],"-1)":[102],"vs.":[103],"dose":[105],"were":[106],"virtually":[107],"coincident":[108],"dissociation":[115],"constant":[116],"(Kb)":[117],"very":[120],"close":[121],"pharmacological":[124,141,231],"value.":[125],"Kb":[129,158,190],"values":[130,191,217],"was":[131,160],"0.65":[132],"1.23":[136],"compared":[139],"cardio-selectivity":[142],"ratios":[143,258],"(measured":[144],"isolated":[146],"atria":[147],"tracheal":[149],"chain)":[150],"67.6":[152],"110":[154],"respectively.":[155],"uterus/heart":[157],"51.5":[161],"atenolol.":[163],"Inhibition":[164],"uterus":[167,251],"gave":[170],"plot":[173],"slope":[175],"significantly":[176],"less":[177],"1,":[179],"indicating":[180],"different":[182],"mechanism":[183],"action":[185],"heart.":[188],"4":[189],"obtained":[192],"measuring":[194],"chopped":[199],"tissue":[200,208],"(including":[201],"bronchial":[204,322],"tree":[205],"alveolar":[207],"as":[209,211,246,248],"well":[210],"whole":[212,223,286,302],"lung)":[213],"resembled":[214],"rather":[218],"those":[220],"found":[221],"organs.":[224],"5":[225],"results":[227],"show":[228,288,304],"that":[229,264,273,289],"selectivity":[232,257],"maintained":[238],"at":[239,244],"receptor-adenylate":[241],"level,":[243],"least":[245],"far":[247],"are":[252],"concerned,":[253],"though":[254],"smaller":[256],"biochemical":[261],"system":[262],"suggest":[263],"receptor":[265],"differences":[266],"not":[268],"only":[270],"factor":[271],"phase":[274,290],"distribution":[275,291],"drug":[278,294],"may":[279,295,310],"also":[280,296],"be":[281,297],"important.":[282,298],"Membranes":[283,299],"an":[305],"overall":[306],"beta1":[307,316],"response":[308],"which":[309],"simply":[311],"reflect":[312],"predominance":[314],"cell":[317],"types":[318],"containing":[319],"beta1-adrenoceptors":[320],"over":[321],"smooth":[323],"muscle.":[324]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}