{"id":"https://openalex.org/W2013761929","doi":"https://doi.org/10.5402/2012/439860","title":"Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide","display_name":"Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide","publication_year":2012,"publication_date":"2012-04-03","ids":{"openalex":"https://openalex.org/W2013761929","doi":"https://doi.org/10.5402/2012/439860","mag":"2013761929","pmid":"https://pubmed.ncbi.nlm.nih.gov/22548186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3324930"},"language":"en","primary_location":{"id":"doi:10.5402/2012/439860","doi":"https://doi.org/10.5402/2012/439860","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/439860","pdf_url":"https://downloads.hindawi.com/archive/2012/439860.pdf","source":{"id":"https://openalex.org/S4210187803","display_name":"ISRN Pharmacology","issn_l":"2090-5165","issn":["2090-5165","2090-5173"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://downloads.hindawi.com/archive/2012/439860.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103132302","display_name":"Megumi Kobayashi","orcid":"https://orcid.org/0000-0002-7688-4805","observed_orcids":["https://orcid.org/0000-0002-7688-4805"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Kobayashi","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009660351","display_name":"Kenta Watanabe","orcid":"https://orcid.org/0000-0002-3357-7207","observed_orcids":["https://orcid.org/0000-0002-3357-7207"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Watanabe","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoshi Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yokoyama","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109508059","display_name":"Chiho Matsumoto","orcid":"https://orcid.org/0009-0002-7944-9910","observed_orcids":["https://orcid.org/0009-0002-7944-9910"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiho Matsumoto","raw_affiliation_strings":["Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111621861","display_name":"Michiko Hirata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko Hirata","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074917906","display_name":"Tsukasa Tominari","orcid":"https://orcid.org/0000-0001-5683-8951","observed_orcids":["https://orcid.org/0000-0001-5683-8951"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsukasa Tominari","raw_affiliation_strings":["Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067353567","display_name":"Masaki Inada","orcid":"https://orcid.org/0000-0002-5066-8506","observed_orcids":["https://orcid.org/0000-0002-5066-8506"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Inada","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079335123","display_name":"Chisato Miyaura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Chisato Miyaura","raw_affiliation_strings":["Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]},{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079335123"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":null,"apc_paid":null,"fwci":0.6144,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.60165821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":1.0},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inflammatory-bone-resorption","display_name":"inflammatory bone resorption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/prostaglandin-e","display_name":"prostaglandin E","score":0.875},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.972000002861023},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/mpges-1","display_name":"mPGES-1","score":0.968999981880188},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.843999981880188},{"id":"https://openalex.org/keywords/bone-disorders","display_name":"bone disease","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.8388461470603943},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.8346574902534485},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.8028832674026489},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7645462155342102},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6872346997261047},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.6137582063674927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6109268665313721},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6040862798690796},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5178144574165344},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.4719373881816864},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4349513351917267},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.41297075152397156},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27815359830856323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2498316764831543},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.12152847647666931}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.5402/2012/439860","doi":"https://doi.org/10.5402/2012/439860","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/439860","pdf_url":"https://downloads.hindawi.com/archive/2012/439860.pdf","source":{"id":"https://openalex.org/S4210187803","display_name":"ISRN Pharmacology","issn_l":"2090-5165","issn":["2090-5165","2090-5173"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Pharmacology","raw_type":"journal-article"},{"id":"pmid:22548186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22548186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3324930","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3324930/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Pharmacol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.9326","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.9326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/48/e2/ISRN_Pharmacol_2012_Apr_3_2012_439860.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2df3d957ebeb4dbbb01430157b1de263","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2df3d957ebeb4dbbb01430157b1de263","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISRN Pharmacology, Vol 2012 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5402/2012/439860","doi":"https://doi.org/10.5402/2012/439860","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2012/439860","pdf_url":"https://downloads.hindawi.com/archive/2012/439860.pdf","source":{"id":"https://openalex.org/S4210187803","display_name":"ISRN Pharmacology","issn_l":"2090-5165","issn":["2090-5165","2090-5173"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5346601877","display_name":"Roles of prostaglandin E on the growth and bone metastasis of cancer.","funder_award_id":"22590058","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5526531407","display_name":"The role of collagenolytic matrix metalloproteinase 13 (MMP13) in cancer growth and metastasis.","funder_award_id":"23590069","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6514827189","display_name":"Analysis of bone selective estrogen and androgen receptor modulators.","funder_award_id":"22790062","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013761929.pdf","grobid_xml":"https://content.openalex.org/works/W2013761929.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1967411130","https://openalex.org/W1988531294","https://openalex.org/W2002708977","https://openalex.org/W2009676510","https://openalex.org/W2017435196","https://openalex.org/W2040664792","https://openalex.org/W2045981686","https://openalex.org/W2058056658","https://openalex.org/W2058097591","https://openalex.org/W2065445418","https://openalex.org/W2113324284","https://openalex.org/W2115293226","https://openalex.org/W2134742719","https://openalex.org/W2148069788","https://openalex.org/W2155427678","https://openalex.org/W2156143641"],"related_works":["https://openalex.org/W7099233153","https://openalex.org/W2156143641","https://openalex.org/W1967411130","https://openalex.org/W2804716773","https://openalex.org/W1970212606","https://openalex.org/W2119496187","https://openalex.org/W4396616590","https://openalex.org/W2059015815","https://openalex.org/W2113324284","https://openalex.org/W2002115720"],"abstract_inverted_index":{"Capsaicin,":[0],"a":[1],"transient":[2],"receptor":[3],"potential":[4],"vanilloid":[5],"type":[6],"1":[7],"(TRPV1)":[8],"ligand,":[9],"regulates":[10],"nerve-related":[11],"pain-sensitive":[12],"signals,":[13],"inflammation,":[14],"and":[15,29,46,57,72,87,93,112,116,138],"cancer":[16],"growth.":[17],"Capsaicin":[18,66,80,101],"suppresses":[19],"interleukin-1-induced":[20],"osteoclast":[21,68],"differentiation,":[22],"but":[23],"its":[24],"roles":[25],"in":[26,55,61,64,78,99,114,133,136,149],"bone":[27,30,44,59,70,118,131,144,164,169],"tissues":[28],"diseases":[31,165],"are":[32],"not":[33],"known.":[34],"This":[35],"study":[36],"examined":[37],"the":[38,82,108,134,142],"effects":[39],"of":[40,84,110],"capsaicin":[41,139,154],"on":[42,58],"inflammatory":[43,143,168],"resorption":[45,119],"prostaglandin":[47],"E":[48],"(PGE)":[49],"production":[50,74,95,105],"induced":[51,75,96,130,146],"by":[52,76,97,106,120,147],"lipopolysaccharide":[53],"(LPS)":[54],"vitro":[56],"mass":[60],"LPS-treated":[62],"mice":[63],"vivo.":[65],"suppressed":[67,81],"formation,":[69],"resorption,":[71],"PGE":[73,89,94,104],"LPS":[77,98,127,148],"vitro.":[79],"expression":[83,109],"cyclooxygenase-2":[85],"(COX-2)":[86],"membrane-bound":[88],"synthase-1":[90],"(mPGES-1)":[91],"mRNAs":[92],"osteoblasts.":[100],"may":[102,155],"suppress":[103],"inhibiting":[107],"COX-2":[111],"mPGES-1":[113],"osteoblasts":[115,124],"LPS-induced":[117],"TRPV1":[121,151],"signals":[122],"because":[123],"express":[125],"TRPV1.":[126],"treatment":[128],"markedly":[129],"loss":[132,145],"femur":[135],"mice,":[137],"significantly":[140],"restored":[141],"mice.":[150],"ligands":[152],"like":[153],"therefore":[156],"be":[157],"potentially":[158],"useful":[159],"as":[160],"clinical":[161],"drugs":[162],"targeting":[163],"associated":[166],"with":[167],"resorption.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}