{"id":"https://openalex.org/W2013758511","doi":"https://doi.org/10.4161/mabs.1.5.9676","title":"Preclinical development of monoclonal antibodies: Considerations for the use of non-human primates","display_name":"Preclinical development of monoclonal antibodies: Considerations for the use of non-human primates","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2013758511","doi":"https://doi.org/10.4161/mabs.1.5.9676","mag":"2013758511","pmid":"https://pubmed.ncbi.nlm.nih.gov/20065651","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2759500"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.1.5.9676","doi":"https://doi.org/10.4161/mabs.1.5.9676","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.1.5.9676","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4161/mabs.1.5.9676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113776484","display_name":"Kathryn L. Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136630","display_name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","ror":"https://ror.org/02w0kg036","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210136630"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Kathryn Chapman","raw_affiliation_strings":["National Centre for Replacement, Refinement and Reduction of Animals in Research, London, UK. kathryn.chapman@nc3rs.org.uk","National Centre for Replacement, Refinement and Reduction of Animals in Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Replacement, Refinement and Reduction of Animals in Research, London, UK. kathryn.chapman@nc3rs.org.uk","institution_ids":["https://openalex.org/I4210136630"]},{"raw_affiliation_string":"National Centre for Replacement, Refinement and Reduction of Animals in Research","institution_ids":["https://openalex.org/I4210136630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053081343","display_name":"Nick Pullen","orcid":"https://orcid.org/0000-0002-4014-9278","observed_orcids":["https://orcid.org/0000-0002-4014-9278"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nick Pullen","raw_affiliation_strings":["Pfizer Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003666837","display_name":"Lee Coney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Coney","raw_affiliation_strings":["Huntingdon Life Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntingdon Life Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015954706","display_name":"Maggie Dempster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maggie Dempster","raw_affiliation_strings":["GlaxoSmithKline"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110993839","display_name":"Laura Andrews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Andrews","raw_affiliation_strings":["Genzyme"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010597291","display_name":"Jeffrey John Bajramovic","orcid":"https://orcid.org/0000-0002-6504-3437","observed_orcids":["https://orcid.org/0000-0002-6504-3437"]},"institutions":[{"id":"https://openalex.org/I2802500869","display_name":"Biomedical Primate Research Centre","ror":"https://ror.org/02ahxbh87","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I2802500869"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeffrey Bajramovic","raw_affiliation_strings":["Biomedical Primate Research Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Primate Research Centre","institution_ids":["https://openalex.org/I2802500869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038520165","display_name":"Paul Baldrick","orcid":"https://orcid.org/0000-0002-3009-3354","observed_orcids":["https://orcid.org/0000-0002-3009-3354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Baldrick","raw_affiliation_strings":["Scientific and Regulatory Consulting, Covance Laboratories"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific and Regulatory Consulting, Covance Laboratories","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064266425","display_name":"Lorrene A. Buckley","orcid":"https://orcid.org/0000-0001-5567-7471","observed_orcids":["https://orcid.org/0000-0001-5567-7471"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorrene Buckley","raw_affiliation_strings":["Eli Lilly and Company","#N##TAB##TAB##TAB##TAB# Eli Lilly and Company#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company","institution_ids":["https://openalex.org/I168537998"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Eli Lilly and Company#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089888292","display_name":"Abby Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abby Jacobs","raw_affiliation_strings":["US Food and Drug Administration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Food and Drug Administration","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000120418","display_name":"G Hale","orcid":"https://orcid.org/0000-0001-9473-423X","observed_orcids":["https://orcid.org/0000-0001-9473-423X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoff Hale","raw_affiliation_strings":["BioAnaLab Limited"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioAnaLab Limited","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Colin Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin Green","raw_affiliation_strings":["Antisoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antisoma","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016384803","display_name":"Ian Ragan","orcid":"https://orcid.org/0000-0002-9589-980X","observed_orcids":["https://orcid.org/0000-0002-9589-980X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Ragan","raw_affiliation_strings":["CIR Consulting Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIR Consulting Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Vicky Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136630","display_name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","ror":"https://ror.org/02w0kg036","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210136630"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vicky Robinson","raw_affiliation_strings":["National Centre for Replacement, Refinement and Reduction of Animals in Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Replacement, Refinement and Reduction of Animals in Research","institution_ids":["https://openalex.org/I4210136630"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5113776484"],"corresponding_institution_ids":["https://openalex.org/I4210136630"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":14.5713,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.99261154,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1","issue":"5","first_page":"505","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9940000176429749},{"id":"https://openalex.org/keywords/preclinical-drug-development","display_name":"preclinical drug development","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.9940000176429749},{"id":"https://openalex.org/keywords/reduction-of-animal-use","display_name":"animal use reduction","score":0.6690000295639038},{"id":"https://openalex.org/keywords/preclinical-safety-evaluation","display_name":"preclinical safety","score":0.7940000295639038},{"id":"https://openalex.org/keywords/development-pathways","display_name":"development pathways","score":0.6539999842643738},{"id":"https://openalex.org/keywords/study-design","display_name":"research design","score":0.8769999742507935},{"id":"https://openalex.org/keywords/regulatory-guidance","display_name":"regulatory guidelines","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6335506439208984},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.5870748162269592},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.5033339858055115},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.44891414046287537},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.38838034868240356},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.35992246866226196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32684779167175293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2504538595676422},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24858352541923523},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18088364601135254},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15328052639961243},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1166234016418457},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011323","descriptor_name":"Primates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016730","descriptor_name":"Program Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/mabs.1.5.9676","doi":"https://doi.org/10.4161/mabs.1.5.9676","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.1.5.9676","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1883936","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2759500","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:20065651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20065651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2759500","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2759500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/mabs.1.5.9676","doi":"https://doi.org/10.4161/mabs.1.5.9676","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.1.5.9676","pdf_url":null,"source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W105230889","https://openalex.org/W1967229902","https://openalex.org/W1980495778","https://openalex.org/W1981720428","https://openalex.org/W1981952228","https://openalex.org/W2008716770","https://openalex.org/W2014276741","https://openalex.org/W2030889094","https://openalex.org/W2034773742","https://openalex.org/W2042154071","https://openalex.org/W2043149287","https://openalex.org/W2044617562","https://openalex.org/W2046759219","https://openalex.org/W2050852087","https://openalex.org/W2052503785","https://openalex.org/W2061872647","https://openalex.org/W2064876070","https://openalex.org/W2068635250","https://openalex.org/W2072313799","https://openalex.org/W2073796343","https://openalex.org/W2083483697","https://openalex.org/W2083982805","https://openalex.org/W2093332691","https://openalex.org/W2093544446","https://openalex.org/W2094397525","https://openalex.org/W2102582447","https://openalex.org/W2105141160","https://openalex.org/W2122348862","https://openalex.org/W2122770255","https://openalex.org/W2141989396","https://openalex.org/W2142499414","https://openalex.org/W2144151587","https://openalex.org/W4299427163"],"related_works":["https://openalex.org/W4391585269","https://openalex.org/W2132235525","https://openalex.org/W1985123137","https://openalex.org/W2987006620","https://openalex.org/W2064876070","https://openalex.org/W4309929520","https://openalex.org/W2762769547","https://openalex.org/W2611831543","https://openalex.org/W2076692468","https://openalex.org/W2014018866"],"abstract_inverted_index":{"The":[0,110],"development":[1,99],"of":[2,13,27,50,84,107,112,134],"mAbs":[3,28,80],"remains":[4],"high":[5],"on":[6,79],"the":[7,11,19,48,72,119],"therapeutic":[8,85],"agenda":[9],"for":[10,23,81,104,118],"majority":[12],"pharmaceutical":[14,60],"and":[15,33,39,61,67,71,76,101,121,131],"biotechnology":[16,62],"companies.":[17],"Often,":[18],"only":[20],"relevant":[21],"species":[22],"preclinical":[24],"safety":[25],"assessment":[26],"are":[29],"non-human":[30],"primates":[31],"(NHPs),":[32],"this":[34],"raises":[35],"important":[36],"scientific,":[37],"ethical":[38],"economic":[40],"issues.":[41],"To":[42],"investigate":[43],"evidence-based":[44],"opportunities":[45],"to":[46,92,95,124],"minimize":[47,128],"use":[49,130],"NHPs,":[51],"an":[52],"expert":[53],"working":[54],"group":[55],"with":[56],"representatives":[57],"from":[58,69],"leading":[59],"companies,":[63],"contract":[64],"research":[65],"organizations":[66],"institutes":[68],"Europe":[70],"USA,":[73],"has":[74,89],"shared":[75],"analyzed":[77],"data":[78],"a":[82,105,115],"range":[83],"areas.":[86],"This":[87],"information":[88],"been":[90],"applied":[91],"hypothetical":[93],"examples":[94],"recommend":[96],"scientifically":[97],"appropriate":[98],"pathways":[100],"study":[102],"designs":[103],"variety":[106],"potential":[108],"mAbs.":[109],"addendum":[111],"ICHS6":[113],"provides":[114],"timely":[116],"opportunity":[117],"scientific":[120],"regulatory":[122],"community":[123],"embrace":[125],"strategies":[126],"which":[127],"primate":[129],"increase":[132],"efficiency":[133],"mAb":[135],"development.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}