{"id":"https://openalex.org/W2013757447","doi":"https://doi.org/10.1016/0165-1781(90)90058-d","title":"Clinical subtypes of unipolar depression: Part III. Quantitative differences in various biological markers between the cluster-analytically generated nonvital and vital depression classes","display_name":"Clinical subtypes of unipolar depression: Part III. Quantitative differences in various biological markers between the cluster-analytically generated nonvital and vital depression classes","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2013757447","doi":"https://doi.org/10.1016/0165-1781(90)90058-d","mag":"2013757447","pmid":"https://pubmed.ncbi.nlm.nih.gov/2176296"},"language":"en","primary_location":{"id":"doi:10.1016/0165-1781(90)90058-d","doi":"https://doi.org/10.1016/0165-1781(90)90058-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(90)90058-d","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032880777","display_name":"Michael H. J. Maes","orcid":"https://orcid.org/0000-0002-2012-871X","observed_orcids":["https://orcid.org/0000-0002-2012-871X","https://orcid.org/0000-0003-2178-7589"]},"institutions":[{"id":"https://openalex.org/I4210102047","display_name":"Antwerp University Hospital","ror":"https://ror.org/01hwamj44","country_code":"BE","type":"funder","lineage":["https://openalex.org/I4210102047"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Michael Maes","raw_affiliation_strings":["Dept. of Biological Psychiatry, University Hospital of Antwerp, Edegem, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biological Psychiatry, University Hospital of Antwerp, Edegem, Belgium","institution_ids":["https://openalex.org/I4210102047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103444153","display_name":"Leo Maes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Maes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004591309","display_name":"Christiaan Schotte","orcid":"https://orcid.org/0000-0003-3674-3626","observed_orcids":["https://orcid.org/0000-0003-3674-3626"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chris Schotte","raw_affiliation_strings":["Vrije Universiteit Brussel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vrije Universiteit Brussel","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071239968","display_name":"Maurits F. J. Vandewoude","orcid":"https://orcid.org/0009-0006-9095-487X","observed_orcids":["https://orcid.org/0009-0006-9095-487X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurits Vandewoude","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109567793","display_name":"M. J. Jim\u00e9nez Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manu Martin","raw_affiliation_strings":["Clinical Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030962566","display_name":"Peter D'Hondt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter D'Hondt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020124874","display_name":"Pierre P. Blockx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Blockx","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109215085","display_name":"Simon Scharp\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Scharpe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033967398","display_name":"Paul R. Cosyns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Cosyns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032880777"],"corresponding_institution_ids":["https://openalex.org/I4210102047"],"apc_list":{"value":4230,"currency":"USD","value_usd":4230},"apc_paid":null,"fwci":2.4699,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87206573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"34","issue":"1","first_page":"59","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.08100000023841858,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.703000009059906},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-thyroid-axis","display_name":"hypothalamic-pituitary-thyroid axis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7329999804496765},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8840000033378601},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9470000267028809},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/depressive-symptoms","display_name":"depressive symptoms","score":0.7459999918937683},{"id":"https://openalex.org/keywords/early-morning-awakening","display_name":"early morning awakening","score":0.546999990940094},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/psychomotor-disorders","display_name":"psychomotor disorders","score":0.9049999713897705},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C113214860","wikidata":"https://www.wikidata.org/wiki/Q1703635","display_name":"Hypothalamic\u2013pituitary\u2013thyroid axis","level":4,"score":0.750313401222229},{"id":"https://openalex.org/C123273963","wikidata":"https://www.wikidata.org/wiki/Q624758","display_name":"Psychopathology","level":2,"score":0.6549283266067505},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5650144219398499},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.540768027305603},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.5005083084106445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48107337951660156},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.44846898317337036},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.44273626804351807},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41462385654449463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38722294569015503},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.35061872005462646},{"id":"https://openalex.org/C2779571634","wikidata":"https://www.wikidata.org/wiki/Q422106","display_name":"Thyroid hormones","level":3,"score":0.2869477868080139},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-1781(90)90058-d","doi":"https://doi.org/10.1016/0165-1781(90)90058-d","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1781(90)90058-d","pdf_url":null,"source":{"id":"https://openalex.org/S84074229","display_name":"Psychiatry Research","issn_l":"0165-1781","issn":["0165-1781","1872-7123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry Research","raw_type":"journal-article"},{"id":"pmid:2176296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2176296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W22839862","https://openalex.org/W83145957","https://openalex.org/W152142219","https://openalex.org/W204015033","https://openalex.org/W290127741","https://openalex.org/W424045140","https://openalex.org/W635543726","https://openalex.org/W1481769490","https://openalex.org/W1501730368","https://openalex.org/W1633465406","https://openalex.org/W1762675619","https://openalex.org/W1889122663","https://openalex.org/W1965374403","https://openalex.org/W1967717054","https://openalex.org/W1970526800","https://openalex.org/W1975429473","https://openalex.org/W1981123235","https://openalex.org/W1983544699","https://openalex.org/W1992738776","https://openalex.org/W1994892766","https://openalex.org/W1995519581","https://openalex.org/W1995873789","https://openalex.org/W1999373512","https://openalex.org/W2000582177","https://openalex.org/W2005992388","https://openalex.org/W2012905838","https://openalex.org/W2014761268","https://openalex.org/W2017177807","https://openalex.org/W2021058884","https://openalex.org/W2021355104","https://openalex.org/W2021783075","https://openalex.org/W2028521995","https://openalex.org/W2028764002","https://openalex.org/W2029705546","https://openalex.org/W2030263867","https://openalex.org/W2032900470","https://openalex.org/W2036063486","https://openalex.org/W2036188152","https://openalex.org/W2040874235","https://openalex.org/W2043697864","https://openalex.org/W2044020099","https://openalex.org/W2048834744","https://openalex.org/W2051734594","https://openalex.org/W2052463336","https://openalex.org/W2055386814","https://openalex.org/W2058375561","https://openalex.org/W2061279089","https://openalex.org/W2061378977","https://openalex.org/W2064738832","https://openalex.org/W2065542333","https://openalex.org/W2071389578","https://openalex.org/W2074917695","https://openalex.org/W2077128950","https://openalex.org/W2081780944","https://openalex.org/W2100563410","https://openalex.org/W2109365975","https://openalex.org/W2114197936","https://openalex.org/W2114613490","https://openalex.org/W2120640169","https://openalex.org/W2127512184","https://openalex.org/W2128328436","https://openalex.org/W2134214170","https://openalex.org/W2138904478","https://openalex.org/W2141907471","https://openalex.org/W2150287316","https://openalex.org/W2160848141","https://openalex.org/W2165817920","https://openalex.org/W2168468239","https://openalex.org/W2169233082","https://openalex.org/W2170928332","https://openalex.org/W2293216275","https://openalex.org/W2313380937","https://openalex.org/W2405197805","https://openalex.org/W2406329971","https://openalex.org/W2413292096","https://openalex.org/W2417600321","https://openalex.org/W2427602948","https://openalex.org/W2444627965","https://openalex.org/W2495395026","https://openalex.org/W2504455232","https://openalex.org/W2614161684","https://openalex.org/W2953607564","https://openalex.org/W3008372243","https://openalex.org/W4212989729","https://openalex.org/W4241888876","https://openalex.org/W4255049920","https://openalex.org/W4301355777"],"related_works":["https://openalex.org/W2002326035","https://openalex.org/W2020019082","https://openalex.org/W2017177807","https://openalex.org/W839712845","https://openalex.org/W2049039993","https://openalex.org/W2065311145","https://openalex.org/W2914364236","https://openalex.org/W2068688382","https://openalex.org/W2021783075","https://openalex.org/W2071457664"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}