{"id":"https://openalex.org/W2013754033","doi":"https://doi.org/10.1126/science.1090389","title":"Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or \u03b1-Synuclein","display_name":"Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or \u03b1-Synuclein","publication_year":2003,"publication_date":"2003-12-04","ids":{"openalex":"https://openalex.org/W2013754033","doi":"https://doi.org/10.1126/science.1090389","mag":"2013754033","pmid":"https://pubmed.ncbi.nlm.nih.gov/14657499"},"language":"en","primary_location":{"id":"doi:10.1126/science.1090389","doi":"https://doi.org/10.1126/science.1090389","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1090389","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028357906","display_name":"Stephen B. Willingham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Willingham","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014020587","display_name":"Tiago F. Outeiro","orcid":"https://orcid.org/0000-0003-1679-1727","observed_orcids":["https://orcid.org/0000-0003-1679-1727"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiago Fleming Outeiro","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032303830","display_name":"Michael J. DeVit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. DeVit","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108509230","display_name":"Susan Lee Lindquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. Lindquist","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008240466","display_name":"Paul J. Muchowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul J. Muchowski","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195\u20137280, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Genome Sciences, University of Washington, Seattle, WA, 98195\u20137730, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008240466"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701","https://openalex.org/I4210157710"],"apc_list":null,"apc_paid":null,"fwci":7.8134,"has_fulltext":false,"cited_by_count":431,"citation_normalized_percentile":{"value":0.9895689,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"302","issue":"5651","first_page":"1769","last_page":"1772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntingtin","display_name":"huntingtin","score":0.546999990940094},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9819999933242798},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.7160000205039978},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/yeast-genetic-screen","display_name":"yeast genetic screen","score":0.4819999933242798},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8069999814033508},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ubiquitin-dependent-protein-degradation","display_name":"ubiquitin-dependent protein degradation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.8930000066757202},{"id":"https://openalex.org/keywords/human-orthologs","display_name":"human orthologs","score":0.6579999923706055},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.9627929925918579},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7475628852844238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6914092302322388},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6772864460945129},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5322964191436768},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4640582799911499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44705572724342346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42221683263778687},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.07740426063537598},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015538","descriptor_name":"Nitrosation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1090389","doi":"https://doi.org/10.1126/science.1090389","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1090389","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:14657499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14657499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1489341550","https://openalex.org/W1541950149","https://openalex.org/W1606232948","https://openalex.org/W1617816798","https://openalex.org/W1967733770","https://openalex.org/W1968942251","https://openalex.org/W1999159261","https://openalex.org/W2005379695","https://openalex.org/W2032817175","https://openalex.org/W2033325995","https://openalex.org/W2033876560","https://openalex.org/W2040706104","https://openalex.org/W2068602144","https://openalex.org/W2073687064","https://openalex.org/W2079250951","https://openalex.org/W2087389265","https://openalex.org/W2091214947","https://openalex.org/W2091265794","https://openalex.org/W2121506107","https://openalex.org/W2121642311","https://openalex.org/W2130323165","https://openalex.org/W2140948740","https://openalex.org/W2142437744","https://openalex.org/W2145669564","https://openalex.org/W2148526984","https://openalex.org/W2150656456","https://openalex.org/W2154761807","https://openalex.org/W2157618233","https://openalex.org/W2160779871","https://openalex.org/W2163012098"],"related_works":["https://openalex.org/W6964622753","https://openalex.org/W2059418506","https://openalex.org/W2914614447","https://openalex.org/W7066081111","https://openalex.org/W1979255038","https://openalex.org/W2149986989","https://openalex.org/W1995181798","https://openalex.org/W833825873","https://openalex.org/W2085066990","https://openalex.org/W2148890034"],"abstract_inverted_index":{"Genome-wide":[0],"screens":[1],"were":[2,31,34,43,102],"performed":[3],"in":[4,66,89,104],"yeast":[5],"to":[6,36,45,54,74,125],"identify":[7],"genes":[8,83,119],"that":[9,33,42,51,57,84,108,122],"enhance":[10],"the":[11,61,67,90],"toxicity":[12,59,87],"of":[13,19,27,60,72,92,117],"a":[14,37],"mutant":[15,38,50,62],"huntingtin":[16,39,63],"fragment":[17,64],"or":[18],"alpha-synuclein.":[20],"Of":[21],"4850":[22],"haploid":[23],"mutants":[24],"containing":[25],"deletions":[26],"nonessential":[28],"genes,":[29],"52":[30],"identified":[32],"sensitive":[35,44,53],"fragment,":[40],"86":[41],"alpha-synuclein,":[46],"and":[47,78,95,114,120,128],"only":[48],"one":[49],"was":[52],"both.":[55],"Genes":[56,98],"enhanced":[58],"clustered":[65,88],"functionally":[68],"related":[69],"cellular":[70],"processes":[71,91],"response":[73],"stress,":[75],"protein":[76,80],"folding,":[77],"ubiquitin-dependent":[79],"catabolism,":[81],"whereas":[82],"modified":[85],"alpha-synuclein":[86],"lipid":[93],"metabolism":[94],"vesicle-mediated":[96],"transport.":[97],"with":[99],"human":[100],"orthologs":[101],"overrepresented":[103],"our":[105],"screens,":[106],"suggesting":[107],"we":[109],"may":[110],"have":[111],"discovered":[112],"conserved":[113],"nonoverlapping":[115],"sets":[116],"cell-autonomous":[118],"pathways":[121],"are":[123],"relevant":[124],"Huntington's":[126],"disease":[127],"Parkinson's":[129],"disease.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}