{"id":"https://openalex.org/W2013740977","doi":"https://doi.org/10.1016/s0140-6736(95)91691-1","title":"Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection","display_name":"Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2013740977","doi":"https://doi.org/10.1016/s0140-6736(95)91691-1","mag":"2013740977","pmid":"https://pubmed.ncbi.nlm.nih.gov/7475549"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(95)91691-1","doi":"https://doi.org/10.1016/s0140-6736(95)91691-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(95)91691-1","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113539739","display_name":"Helmut Michael Diepolder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259207","display_name":"Institut f\u00fcr Immunologie","ror":"https://ror.org/01x8c0495","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"H.M. Diepolder","raw_affiliation_strings":["Institute for Immunology, Klinikum Grosshadern, University of Munich, Germany","Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology, Klinikum Grosshadern, University of Munich, Germany","institution_ids":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044524026","display_name":"Roman Zachoval","orcid":"https://orcid.org/0000-0003-0906-269X","observed_orcids":["https://orcid.org/0000-0003-0906-269X"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Zachoval","raw_affiliation_strings":["Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052820298","display_name":"Robert M. Hoffmann","orcid":"https://orcid.org/0000-0001-9850-6277","observed_orcids":["https://orcid.org/0000-0001-9850-6277"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R.M. Hoffmann","raw_affiliation_strings":["Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103749420","display_name":"MC Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M-C. Jung","raw_affiliation_strings":["Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112757937","display_name":"G. R. Pape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G.R. Pape","raw_affiliation_strings":["Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Department of Medicine II, Klinikum Grosshadern, University of Munich, 81377 Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110046633","display_name":"Eddy A. Wierenga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E.A. Wierenga","raw_affiliation_strings":["Laboratory of Cell Biology and Histology, University of Amsterdam, Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology and Histology, University of Amsterdam, Amsterdam, Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085265275","display_name":"Teresa Antonia Santantonio","orcid":"https://orcid.org/0000-0002-4342-6904","observed_orcids":["https://orcid.org/0000-0002-4342-6904"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"T. Santantonio","raw_affiliation_strings":["Clinica Malattie Infettive, Universita degli studi di Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Malattie Infettive, Universita degli studi di Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025108028","display_name":"Dieter Eichenlaub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091445","display_name":"M\u00fcnchen Klinik Schwabing","ror":"https://ror.org/002bjfj29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210091445","https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Eichenlaub","raw_affiliation_strings":["IV Department of Internal Medicine, Hospital Schwabing, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IV Department of Internal Medicine, Hospital Schwabing, Munich, Germany","institution_ids":["https://openalex.org/I4210091445"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113539739"],"corresponding_institution_ids":["https://openalex.org/I4405259207","https://openalex.org/I8204097"],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":17.6664,"has_fulltext":false,"cited_by_count":686,"citation_normalized_percentile":{"value":0.99417574,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"346","issue":"8981","first_page":"1006","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.8880000114440918},{"id":"https://openalex.org/keywords/acute-hepatitis-c","display_name":"acute hepatitis C","score":0.9160000085830688},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nsp3","display_name":"NSP3","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ns3","display_name":"NS3","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.6520000100135803},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9010000228881836},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hcv-core-protein","display_name":"HCV core protein","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.8108824491500854},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7039964199066162},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6514646410942078},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6490709185600281},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6110955476760864},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5890130996704102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5648231506347656},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5470827221870422},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5081610679626465},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4773164689540863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28205519914627075},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0798063576221466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(95)91691-1","doi":"https://doi.org/10.1016/s0140-6736(95)91691-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0140-6736(95)91691-1","pdf_url":null,"source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:7475549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7475549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1582747522","https://openalex.org/W1867663745","https://openalex.org/W1977677882","https://openalex.org/W1982554992","https://openalex.org/W1993023565","https://openalex.org/W1994838458","https://openalex.org/W2003521386","https://openalex.org/W2055219788","https://openalex.org/W2121339743","https://openalex.org/W2328171401","https://openalex.org/W4246381730","https://openalex.org/W6651168061"],"related_works":["https://openalex.org/W7097751178","https://openalex.org/W2074723596","https://openalex.org/W2001780337","https://openalex.org/W6889043231","https://openalex.org/W4244325660","https://openalex.org/W2079432353","https://openalex.org/W2020346251","https://openalex.org/W2014179324","https://openalex.org/W2031968946","https://openalex.org/W2046281053"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":21}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}