{"id":"https://openalex.org/W2013717602","doi":"https://doi.org/10.1074/jbc.m008173200","title":"The N-terminal N5 Subdomain of the \u03b13(VI) Chain Is Important for Collagen VI Microfibril Formation","display_name":"The N-terminal N5 Subdomain of the \u03b13(VI) Chain Is Important for Collagen VI Microfibril Formation","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2013717602","doi":"https://doi.org/10.1074/jbc.m008173200","mag":"2013717602","pmid":"https://pubmed.ncbi.nlm.nih.gov/11027693"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m008173200","doi":"https://doi.org/10.1074/jbc.m008173200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m008173200","pdf_url":"http://www.jbc.org/article/S002192581844224X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581844224X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jamie Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jamie Fitzgerald","raw_affiliation_strings":["Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, Victoria 3052, Australia","\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045374933","display_name":"Matthias M\u00f6rgelin","orcid":"https://orcid.org/0000-0002-6212-6990","observed_orcids":["https://orcid.org/0000-0002-6212-6990"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Matthias M\u00f6rgelin","raw_affiliation_strings":["\u00a7Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, S-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, S-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014892480","display_name":"Carly Selan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carly Selan","raw_affiliation_strings":["\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112516871","display_name":"Charlotte Wiberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Charlotte Wiberg","raw_affiliation_strings":["\u00a7Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, S-221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Section for Connective Tissue Biology, Department of Cell and Molecular Biology, Lund University, S-221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040445442","display_name":"Douglas R. Keene","orcid":"https://orcid.org/0000-0003-2986-370X","observed_orcids":["https://orcid.org/0000-0003-2986-370X"]},"institutions":[{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R. Keene","raw_affiliation_strings":["\u00b6Shriners Hospital Research Facility, Portland, Oregon 97201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Shriners Hospital Research Facility, Portland, Oregon 97201","institution_ids":["https://openalex.org/I2800078164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024478104","display_name":"Shireen R. Lamand\u00e9","orcid":"https://orcid.org/0000-0003-2938-2711","observed_orcids":["https://orcid.org/0000-0003-2938-2711"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Shireen R. Lamand\u00e9","raw_affiliation_strings":["\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027780831","display_name":"John F. Bateman","orcid":"https://orcid.org/0000-0001-8542-0730","observed_orcids":["https://orcid.org/0000-0001-8542-0730","https://orcid.org/0000-0002-7209-9295"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John F. Bateman","raw_affiliation_strings":["\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Cell and Matrix Biology Research Unit, Department of Paediatrics, University of Melbourne, and the Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024478104"],"corresponding_institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4559,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.80749194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"276","issue":"1","first_page":"187","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":0.9959999918937683},{"id":"https://openalex.org/keywords/collagen-self-assembly","display_name":"collagen self-assembly","score":0.5440000295639038},{"id":"https://openalex.org/keywords/triple-helix","display_name":"triple helix","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tetramer-assembly","display_name":"tetramer assembly","score":0.6309999823570251},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.796999990940094},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2776455902","wikidata":"https://www.wikidata.org/wiki/Q417913","display_name":"Microfibril","level":3,"score":0.7713217735290527},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6269094347953796},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5665110945701599},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5555331707000732},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.46718552708625793},{"id":"https://openalex.org/C10919887","wikidata":"https://www.wikidata.org/wiki/Q7843514","display_name":"Triple helix","level":2,"score":0.43442708253860474},{"id":"https://openalex.org/C2778873089","wikidata":"https://www.wikidata.org/wiki/Q3281418","display_name":"Collagen VI","level":3,"score":0.4323117136955261},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.41988953948020935},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.41688403487205505},{"id":"https://openalex.org/C155181932","wikidata":"https://www.wikidata.org/wiki/Q24768908","display_name":"Collagen helix","level":3,"score":0.41009700298309326},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35278886556625366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3105916976928711},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3097960352897644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22431603074073792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09768703579902649},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020894","descriptor_name":"Microfibrils","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020894","descriptor_name":"Microfibrils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020894","descriptor_name":"Microfibrils","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m008173200","doi":"https://doi.org/10.1074/jbc.m008173200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m008173200","pdf_url":"http://www.jbc.org/article/S002192581844224X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11027693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11027693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:d1eca5e8-2bfc-4673-96f7-7c887b5c7194","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1120841","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1083-351X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m008173200","doi":"https://doi.org/10.1074/jbc.m008173200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m008173200","pdf_url":"http://www.jbc.org/article/S002192581844224X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013717602.pdf","grobid_xml":"https://content.openalex.org/works/W2013717602.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W92534390","https://openalex.org/W569951484","https://openalex.org/W571245376","https://openalex.org/W1482127541","https://openalex.org/W1498798237","https://openalex.org/W1526730706","https://openalex.org/W1539731456","https://openalex.org/W1541466209","https://openalex.org/W1583533334","https://openalex.org/W1598660200","https://openalex.org/W1834208879","https://openalex.org/W1856207023","https://openalex.org/W1959440999","https://openalex.org/W1976243723","https://openalex.org/W2002226831","https://openalex.org/W2003381179","https://openalex.org/W2030580477","https://openalex.org/W2035043977","https://openalex.org/W2039645505","https://openalex.org/W2048119886","https://openalex.org/W2050790881","https://openalex.org/W2072030041","https://openalex.org/W2082454321","https://openalex.org/W2122309353","https://openalex.org/W2127734452","https://openalex.org/W2137284441","https://openalex.org/W2139199445","https://openalex.org/W2144634347","https://openalex.org/W2163357748","https://openalex.org/W2223764435","https://openalex.org/W2314225431","https://openalex.org/W2399187687","https://openalex.org/W2401079384"],"related_works":["https://openalex.org/W2167451834","https://openalex.org/W2072030041","https://openalex.org/W2238722478","https://openalex.org/W2127790326","https://openalex.org/W7000923616","https://openalex.org/W2045499302","https://openalex.org/W2401079384","https://openalex.org/W2125922121","https://openalex.org/W1980474802","https://openalex.org/W1834208879"],"abstract_inverted_index":{"Collagen":[0],"VI":[1,113,187,218,251,280],"assembly":[2],"is":[3,262],"unique":[4],"within":[5],"the":[6,11,36,44,57,67,102,106,157,203,225,257],"collagen":[7,112,186,217,250,279],"superfamily":[8],"in":[9,51,62,91,111,237,278],"that":[10,48,136,197,223,256],"alpha":[12,14,17,118,138,170,179,182,199,206,227,258],"1(VI),":[13],"2(VI),":[15],"and":[16,27,30,115,161,181,190,210,214,232,245],"3(VI)":[18,119,139,171,200,207,228,259],"chains":[19,140,172,201],"associate":[20,40,176],"intracellularly":[21],"to":[22,42,86,175,184,240,247],"form":[23,43,185,241],"triple":[24,159],"helical":[25],"monomers,":[26,188],"then":[28],"dimers":[29],"tetramers,":[31,191],"which":[32,71,192],"are":[33,49,65,72,84,96],"secreted":[34],"from":[35],"cell.":[37],"Secreted":[38],"tetramers":[39],"end-to-end":[41,242],"distinctive":[45],"extracellular":[46,116],"microfibrils":[47,213],"found":[50],"virtually":[52],"all":[53],"connective":[54],"tissues.":[55],"Although":[56],"precise":[58],"protein":[59],"interactions":[60],"involved":[61],"this":[63],"process":[64],"unknown,":[66],"N-terminal":[68,125,142],"globular":[69,143,163],"regions,":[70],"composed":[73],"of":[74,77,101,108,167],"multiple":[75],"copies":[76],"von":[78],"Willebrand":[79],"factor":[80],"type":[81,275],"A-like":[82],"domains,":[83],"likely":[85],"play":[87],"a":[88,216,249,269,273],"critical":[89,263],"role":[90,107,271],"microfibril":[92,265],"formation,":[93,266],"because":[94],"they":[95],"exposed":[97],"at":[98],"both":[99],"ends":[100],"tetramers.":[103],"To":[104],"explore":[105],"these":[109,168],"subdomains":[110],"intracellular":[114],"assembly,":[117],"cDNA":[120],"expression":[121],"constructs":[122],"with":[123,141,177],"sequential":[124],"deletions":[126],"were":[127,173,193,234],"stably":[128],"transfected":[129,169],"into":[130],"SaOS-2":[131],"cells,":[132],"producing":[133],"cell":[134],"lines":[135],"express":[137],"domains":[144],"containing":[145,202],"modules":[146],"N9-N1,":[147],"N6-N1,":[148],"N5-N1,":[149],"N4-N1,":[150],"N3-N1,":[151],"or":[152],"N1,":[153],"as":[154,156],"well":[155],"complete":[158],"helix":[160],"C-terminal":[162],"domain":[164],"(C1-C5).":[165],"All":[166],"able":[174],"endogenous":[178],"1(VI)":[180],"2(VI)":[183],"dimers,":[189],"secreted.":[194],"Importantly,":[195],"cells":[196,222],"expressed":[198,224],"N5":[204,260],"subdomain,":[205],"N9-C5,":[208],"N6-C5,":[209],"N5-C5,":[211],"formed":[212],"deposited":[215],"matrix.":[219,252],"In":[220],"contrast,":[221],"shorter":[226],"chains,":[229],"N4-C5,":[230],"N3-C5,":[231],"N1-C5,":[233],"severely":[235],"compromised":[236],"their":[238],"ability":[239],"tetramer":[243],"assemblies":[244],"failed":[246],"deposit":[248],"These":[253],"data":[254],"demonstrate":[255],"module":[261],"for":[264,272],"thus":[267],"identifying":[268],"functional":[270],"specific":[274],"A":[276],"subdomain":[277],"assembly.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}