{"id":"https://openalex.org/W2013706950","doi":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","title":"A Decade of Tau Transgenic Animal Models and Beyond","display_name":"A Decade of Tau Transgenic Animal Models and Beyond","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2013706950","doi":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","mag":"2013706950","pmid":"https://pubmed.ncbi.nlm.nih.gov/17493043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8095624"},"language":"en","primary_location":{"id":"doi:10.1111/j.1750-3639.2007.00051.x","doi":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8095624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045325665","display_name":"J\u00fcrgen G\u00f6tz","orcid":"https://orcid.org/0000-0001-8501-7896","observed_orcids":["https://orcid.org/0000-0001-8501-7896","https://orcid.org/0000-0002-2003-9135"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen G\u00f6tz","raw_affiliation_strings":["Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia. jgoetz@med.usyd.edu.au","Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia. jgoetz@med.usyd.edu.au","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060523292","display_name":"Natasha A. Deters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natasha Deters","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072060301","display_name":"Amy Doldissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amy Doldissen","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042988931","display_name":"Laita Bokhari","orcid":"https://orcid.org/0000-0003-4522-2611","observed_orcids":["https://orcid.org/0000-0003-4522-2611"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Laita Bokhari","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030210067","display_name":"Yazi Diana Ke","orcid":"https://orcid.org/0000-0002-1423-0451","observed_orcids":["https://orcid.org/0000-0002-1423-0451"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yazi Ke","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andreas Wiesner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andreas Wiesner","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021245416","display_name":"Nicole Sch\u00f6nrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicole Schonrock","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073763982","display_name":"Lars Matthias Ittner","orcid":"https://orcid.org/0000-0001-6738-3825","observed_orcids":["https://orcid.org/0000-0001-6738-3825"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lars M. Ittner","raw_affiliation_strings":["Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s and Parkinson\u2019s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045325665"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":1.3671,"has_fulltext":false,"cited_by_count":179,"citation_normalized_percentile":{"value":0.78965517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"91","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7950000166893005},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6919999718666077},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9399999976158142},{"id":"https://openalex.org/keywords/disease-modifiers","display_name":"disease modifiers","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.625}],"concepts":[{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.7291914820671082},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6954198479652405},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6717448234558105},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.6550199389457703},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5779315829277039},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5551943182945251},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5174927711486816},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5031909346580505},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.4912070631980896},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.46682876348495483},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45366647839546204},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36491328477859497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35649412870407104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3389695882797241},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30140966176986694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12874993681907654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.125422865152359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07489567995071411}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1750-3639.2007.00051.x","doi":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1750-3639.2007.00051.x","pdf_url":null,"source":{"id":"https://openalex.org/S9094144","display_name":"Brain Pathology","issn_l":"1015-6305","issn":["1015-6305","1750-3639"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8095624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8095624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},{"id":"pmid:17493043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17493043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain pathology (Zurich, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8095624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8095624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W93810211","https://openalex.org/W1480786153","https://openalex.org/W1511517753","https://openalex.org/W1528219518","https://openalex.org/W1528908480","https://openalex.org/W1554589427","https://openalex.org/W1564414547","https://openalex.org/W1567490604","https://openalex.org/W1567624342","https://openalex.org/W1588056165","https://openalex.org/W1600934558","https://openalex.org/W1603257718","https://openalex.org/W1621971853","https://openalex.org/W1625241616","https://openalex.org/W1653014745","https://openalex.org/W1693283493","https://openalex.org/W1893543180","https://openalex.org/W1934627856","https://openalex.org/W1965201584","https://openalex.org/W1965232330","https://openalex.org/W1965275873","https://openalex.org/W1965381538","https://openalex.org/W1966341425","https://openalex.org/W1967410657","https://openalex.org/W1967464880","https://openalex.org/W1974760231","https://openalex.org/W1977892449","https://openalex.org/W1978932408","https://openalex.org/W1979481666","https://openalex.org/W1980768099","https://openalex.org/W1981628681","https://openalex.org/W1984909573","https://openalex.org/W1985659039","https://openalex.org/W1986349982","https://openalex.org/W1987385089","https://openalex.org/W1987927755","https://openalex.org/W1989146486","https://openalex.org/W1989301820","https://openalex.org/W1990573749","https://openalex.org/W1992491411","https://openalex.org/W1992503511","https://openalex.org/W1992973287","https://openalex.org/W1995208082","https://openalex.org/W1996239144","https://openalex.org/W1998276610","https://openalex.org/W1999486930","https://openalex.org/W2005759199","https://openalex.org/W2005809770","https://openalex.org/W2009174342","https://openalex.org/W2009945323","https://openalex.org/W2010607678","https://openalex.org/W2012666269","https://openalex.org/W2015522247","https://openalex.org/W2016758992","https://openalex.org/W2017222498","https://openalex.org/W2019036194","https://openalex.org/W2019152247","https://openalex.org/W2020815630","https://openalex.org/W2021518571","https://openalex.org/W2021590064","https://openalex.org/W2025391244","https://openalex.org/W2025922492","https://openalex.org/W2027582763","https://openalex.org/W2030804652","https://openalex.org/W2031259748","https://openalex.org/W2032920422","https://openalex.org/W2033198098","https://openalex.org/W2033529907","https://openalex.org/W2035156043","https://openalex.org/W2035470211","https://openalex.org/W2036011584","https://openalex.org/W2038120434","https://openalex.org/W2040661002","https://openalex.org/W2041229701","https://openalex.org/W2041544905","https://openalex.org/W2044974101","https://openalex.org/W2046196399","https://openalex.org/W2046847750","https://openalex.org/W2050553218","https://openalex.org/W2051561353","https://openalex.org/W2053923103","https://openalex.org/W2054619408","https://openalex.org/W2055588023","https://openalex.org/W2057764483","https://openalex.org/W2058876934","https://openalex.org/W2059861908","https://openalex.org/W2061076128","https://openalex.org/W2061425816","https://openalex.org/W2064244929","https://openalex.org/W2064587868","https://openalex.org/W2065032350","https://openalex.org/W2066068917","https://openalex.org/W2066502884","https://openalex.org/W2066792703","https://openalex.org/W2067042124","https://openalex.org/W2068204174","https://openalex.org/W2068778297","https://openalex.org/W2069466136","https://openalex.org/W2073688317","https://openalex.org/W2077699648","https://openalex.org/W2077819646","https://openalex.org/W2082429191","https://openalex.org/W2083337183","https://openalex.org/W2084021257","https://openalex.org/W2084453905","https://openalex.org/W2086422907","https://openalex.org/W2087620664","https://openalex.org/W2087745495","https://openalex.org/W2088384294","https://openalex.org/W2088445065","https://openalex.org/W2091864083","https://openalex.org/W2093439345","https://openalex.org/W2097094654","https://openalex.org/W2098077028","https://openalex.org/W2101523938","https://openalex.org/W2103147849","https://openalex.org/W2105704879","https://openalex.org/W2107438114","https://openalex.org/W2110193116","https://openalex.org/W2110793364","https://openalex.org/W2110888808","https://openalex.org/W2111567059","https://openalex.org/W2112216133","https://openalex.org/W2120178938","https://openalex.org/W2121448546","https://openalex.org/W2124881367","https://openalex.org/W2126906272","https://openalex.org/W2128121742","https://openalex.org/W2129677617","https://openalex.org/W2130723719","https://openalex.org/W2130924200","https://openalex.org/W2131177593","https://openalex.org/W2132211728","https://openalex.org/W2134365974","https://openalex.org/W2134720398","https://openalex.org/W2135309154","https://openalex.org/W2135661040","https://openalex.org/W2136673626","https://openalex.org/W2136709809","https://openalex.org/W2139553041","https://openalex.org/W2140668393","https://openalex.org/W2141653500","https://openalex.org/W2141839336","https://openalex.org/W2144795344","https://openalex.org/W2145631524","https://openalex.org/W2148570557","https://openalex.org/W2150802333","https://openalex.org/W2161409513","https://openalex.org/W2165725890","https://openalex.org/W2166747071","https://openalex.org/W2168957011","https://openalex.org/W2170725855","https://openalex.org/W2171776741","https://openalex.org/W2172007938","https://openalex.org/W2280112761","https://openalex.org/W2401135841","https://openalex.org/W2606648674","https://openalex.org/W4230565756","https://openalex.org/W4252934541","https://openalex.org/W7097231284"],"related_works":["https://openalex.org/W2041229701","https://openalex.org/W43935026","https://openalex.org/W2772302117","https://openalex.org/W2038036050","https://openalex.org/W1990397297","https://openalex.org/W2132018272","https://openalex.org/W4416663118","https://openalex.org/W2091088463","https://openalex.org/W2969504130","https://openalex.org/W2002521150"],"abstract_inverted_index":{"The":[0],"first":[1],"tau":[2,23,68,86,110,138,152],"transgenic":[3],"mouse":[4],"model":[5],"was":[6],"established":[7],"more":[8,122],"than":[9,115],"a":[10,43,121,132,146],"decade":[11],"ago.":[12],"Since":[13],"then,":[14],"much":[15],"has":[16,111],"been":[17,61,89],"learned":[18],"about":[19],"the":[20,46,65,70,77,85,93,126,143,155,161],"role":[21],"of":[22,45,48,56,74,95,131,135,145,148,157,163],"in":[24,33,51,53,139,154],"Alzheimer's":[25,75,96,140],"disease":[26,101],"and":[27,35,40,69,103,125,137],"related":[28],"disorders.":[29],"Animal":[30],"models,":[31],"both":[32],"vertebrates":[34],"invertebrates,":[36],"were":[37],"significantly":[38],"improved":[39],"refined":[41],"as":[42],"result":[44],"identification":[47],"pathogenic":[49],"mutations":[50],"Tau":[52],"human":[54],"cases":[55],"frontotemporal":[57],"dementia.":[58],"They":[59],"have":[60,88],"instrumental":[62],"for":[63,100],"dissecting":[64],"cross-talk":[66],"between":[67],"second":[71],"hallmark":[72],"lesion":[73],"disease,":[76,97],"Abeta":[78,136],"peptide-containing":[79],"amyloid":[80],"plaque.":[81],"We":[82],"discuss":[83],"how":[84],"models":[87],"used":[90],"to":[91,98,104],"unravel":[92],"pathophysiology":[94],"search":[99],"modifiers":[102],"develop":[105],"novel":[106],"treatment":[107],"strategies.":[108],"While":[109],"received":[112],"less":[113],"attention":[114],"Abeta,":[116],"it":[117],"is":[118,129],"rapidly":[119],"acquiring":[120],"prominent":[123],"position":[124],"emerging":[127],"view":[128],"one":[130],"synergistic":[133],"action":[134],"disease.":[141],"Moreover,":[142],"existence":[144],"number":[147],"neurodegenerative":[149],"diseases":[150],"with":[151],"pathology":[153],"absence":[156],"extracellular":[158],"deposits":[159],"underscores":[160],"relevance":[162],"research":[164],"on":[165],"tau.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}