{"id":"https://openalex.org/W2013700933","doi":"https://doi.org/10.1007/bf01244634","title":"Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain","display_name":"Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W2013700933","doi":"https://doi.org/10.1007/bf01244634","mag":"2013700933","pmid":"https://pubmed.ncbi.nlm.nih.gov/2897999"},"language":"en","primary_location":{"id":"doi:10.1007/bf01244634","doi":"https://doi.org/10.1007/bf01244634","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01244634","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081862693","display_name":"Makio Mogi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Mogi","raw_affiliation_strings":["Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082446279","display_name":"Minoru Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Harada","raw_affiliation_strings":["Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073916948","display_name":"Kazutoshi Kiuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Kiuchi","raw_affiliation_strings":["Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034877577","display_name":"Kohichi Kojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122431","display_name":"Food and Drug Safety Center","ror":"https://ror.org/02rmwfb84","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210122431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Kojima","raw_affiliation_strings":["Hatano Research Institute, Food and Drug Safety Center, Hatano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hatano Research Institute, Food and Drug Safety Center, Hatano, Japan","institution_ids":["https://openalex.org/I4210122431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000365632","display_name":"Toshikazu Kondo","orcid":"https://orcid.org/0000-0002-5059-8309","observed_orcids":["https://orcid.org/0000-0002-5059-8309"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kondo","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029484704","display_name":"Hirotaro Narabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Narabayashi","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002584058","display_name":"Dylan M. Rausch","orcid":"https://orcid.org/0000-0001-6095-4891","observed_orcids":["https://orcid.org/0000-0001-6095-4891"]},"institutions":[{"id":"https://openalex.org/I150540706","display_name":"University of Veterinary Medicine Vienna","ror":"https://ror.org/01w6qp003","country_code":"AT","type":"education","lineage":["https://openalex.org/I150540706"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"D. Rausch","raw_affiliation_strings":["Institute for Medical Chemistry, Veterinarian Medical University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Chemistry, Veterinarian Medical University, Vienna, Austria","institution_ids":["https://openalex.org/I150540706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069476421","display_name":"Peter Franz Riederer","orcid":"https://orcid.org/0000-0002-3453-6335","observed_orcids":["https://orcid.org/0000-0002-3453-6335"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Riederer","raw_affiliation_strings":["Clinical Neurochemistry, Department of Psychiatry, University of W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry, Department of Psychiatry, University of W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042083351","display_name":"K. A. Jellinger","orcid":"https://orcid.org/0000-0002-9641-7649","observed_orcids":["https://orcid.org/0000-0002-9641-7649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Jellinger","raw_affiliation_strings":["Ludwig Boltzmann Institute for Clinical Neurobiology, Lainz-Hospital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Boltzmann Institute for Clinical Neurobiology, Lainz-Hospital, Vienna, Austria","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004939550","display_name":"Toshiharu Nagatsu","orcid":"https://orcid.org/0000-0002-9216-6029","observed_orcids":["https://orcid.org/0000-0002-9216-6029"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Nagatsu","raw_affiliation_strings":["Department of Biochemistry; Nagoya University School of Medicine; Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry; Nagoya University School of Medicine; Nagoya Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":4.9561,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.95524027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"72","issue":"1","first_page":"77","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/enzyme-protein-content","display_name":"enzyme protein content","score":0.8600000143051147},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":1.0},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.8616348505020142},{"id":"https://openalex.org/C2909129545","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine 3-Monooxygenase","level":4,"score":0.6801354885101318},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6213250756263733},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.5055539608001709},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5005574226379395},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.47449398040771484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4171212315559387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4047112464904785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.379989355802536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3647930324077606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34583330154418945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32678085565567017},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2938392460346222}],"mesh":[{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01244634","doi":"https://doi.org/10.1007/bf01244634","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01244634","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},{"id":"pmid:2897999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2897999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1983823130","https://openalex.org/W1984292807","https://openalex.org/W1993513520","https://openalex.org/W2006784273","https://openalex.org/W2010398012","https://openalex.org/W2042196312","https://openalex.org/W2044703125","https://openalex.org/W2056746109","https://openalex.org/W2074975109","https://openalex.org/W2080419647","https://openalex.org/W2117053539","https://openalex.org/W2164398262","https://openalex.org/W2167997953","https://openalex.org/W2408486246"],"related_works":["https://openalex.org/W2315634470","https://openalex.org/W2208912970","https://openalex.org/W2027612709","https://openalex.org/W1965031776","https://openalex.org/W2028218126","https://openalex.org/W2408486246","https://openalex.org/W1972376911","https://openalex.org/W2402359054","https://openalex.org/W2486606337","https://openalex.org/W2009043849"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
