{"id":"https://openalex.org/W2013700733","doi":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","title":"Thrombopoietic properties of 5\u2010methoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer\u2010related thrombocytopenia","display_name":"Thrombopoietic properties of 5\u2010methoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer\u2010related thrombocytopenia","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2013700733","doi":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","mag":"2013700733","pmid":"https://pubmed.ncbi.nlm.nih.gov/11270479"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-079x.2001.300208.x","doi":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113805869","display_name":"Paolo Lissoni","orcid":"https://orcid.org/0000-0002-5374-1350","observed_orcids":["https://orcid.org/0000-0002-5374-1350"]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"P. Lissoni","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085115321","display_name":"R Bucovec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Bucovec","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Bonfanti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Bonfanti","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024090764","display_name":"Luisa Giani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Giani","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Mandelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Mandelli","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110156261","display_name":"M Roselli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M.G. Roselli","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108516170","display_name":"Franco Rovelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Rovelli","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031089579","display_name":"Luca A. Fumagalli","orcid":"https://orcid.org/0000-0003-4690-1712","observed_orcids":["https://orcid.org/0000-0003-4690-1712"]},"institutions":[{"id":"https://openalex.org/I4210110840","display_name":"Azienda Ospedaliera San Gerardo","ror":"https://ror.org/01xf83457","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210110840"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Fumagalli","raw_affiliation_strings":["Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy","institution_ids":["https://openalex.org/I4210110840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113805869"],"corresponding_institution_ids":["https://openalex.org/I4210110840"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.0476,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.7637219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"30","issue":"2","first_page":"123","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-methoxytryptamine","display_name":"5-methoxytryptamine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.968999981880188},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8100000023841858},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.9884938597679138},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.6020355224609375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5861731171607971},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46208569407463074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40078556537628174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33758074045181274}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008735","descriptor_name":"5-Methoxytryptamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-079x.2001.300208.x","doi":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-079x.2001.300208.x","pdf_url":null,"source":{"id":"https://openalex.org/S114728194","display_name":"Journal of Pineal Research","issn_l":"0742-3098","issn":["0742-3098","1600-079X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pineal Research","raw_type":"journal-article"},{"id":"pmid:11270479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11270479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pineal research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2467627008","https://openalex.org/W2020447311","https://openalex.org/W2140236822","https://openalex.org/W10110336","https://openalex.org/W2230226949","https://openalex.org/W7028258113","https://openalex.org/W3176954102","https://openalex.org/W1978312228","https://openalex.org/W2415926415","https://openalex.org/W2165532934"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"shown":[3,29],"that":[4,171],"the":[5,24,34,50,68,75,108,118,141,158],"hematopoietic":[6],"system":[7],"is":[8],"under":[9],"neuroendocrine":[10],"control.":[11],"In":[12],"particular,":[13],"thrombopoiesis":[14],"has":[15,27],"been":[16,28],"proven":[17],"to":[18,30,66,88,100,187],"be":[19,31,185],"stimulated":[20],"by":[21,202],"melatonin,":[22],"and":[23,137],"pineal":[25,55,76,174],"indole":[26,77],"effective":[32],"in":[33,79,107,117,128,138,157],"treatment":[35],"of":[36,54,70,74,123,140],"thrombocytopenia":[37,83],"resulting":[38],"from":[39],"different":[40],"causes.":[41],"At":[42],"present,":[43],"however,":[44,183],"there":[45],"are":[46],"no":[47],"data":[48],"concerning":[49],"possible":[51],"thrombopoietic":[52,179,195],"activity":[53],"indoles":[56],"other":[57],"than":[58],"melatonin.":[59],"The":[60,91],"present":[61,92],"study":[62,93,168],"was":[63,126],"carried":[64],"out":[65],"evaluate":[67],"effect":[69],"a":[71,173,193],"concomitant":[72],"administration":[73],"5-methoxytryptamine":[78,113,136,190],"patients":[80,131,142,159],"with":[81,133,144,161],"cancer-related":[82],"who":[84,97],"did":[85],"not":[86],"respond":[87],"melatonin":[89,102,111,134,145,162],"alone.":[90],"included":[94],"30":[95],"patients,":[96],"were":[98],"randomized":[99],"receive":[101],"alone":[103,146],"(20":[104],"mg/day":[105,115],"orally":[106,116],"evening)":[109],"or":[110,197],"plus":[112,135,163],"(1":[114],"early":[119],"afternoon).":[120],"A":[121],"normalization":[122],"platelet":[124,152],"count":[125],"achieved":[127],"5/14":[129],"(36%)":[130],"treated":[132,143,160],"none":[139],"(P":[147],"<":[148],"0.05).":[149],"Moreover,":[150],"mean":[151],"number":[153],"significantly":[154],"increased":[155],"only":[156],"5-methoxytryptamine.":[164],"This":[165],"preliminary":[166],"clinical":[167],"would":[169],"suggest":[170],"5-methoxytryptamine,":[172],"indole,":[175],"may":[176,191,200],"also":[177],"exert":[178],"activity.":[180],"Further":[181],"studies,":[182],"will":[184],"required":[186],"establish":[188],"whether":[189,198],"play":[192],"direct":[194],"activity,":[196],"it":[199],"act":[201],"improving":[203],"melatonin's":[204],"efficacy.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}