{"id":"https://openalex.org/W2013682277","doi":"https://doi.org/10.1097/00007890-199809270-00016","title":"TUBULAR ANTITHROMBIN AT TRANSPLANTATION DETERMINES SUBSEQUENT RENAL ALLOGRAFT FUNCTION1,2","display_name":"TUBULAR ANTITHROMBIN AT TRANSPLANTATION DETERMINES SUBSEQUENT RENAL ALLOGRAFT FUNCTION1,2","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2013682277","doi":"https://doi.org/10.1097/00007890-199809270-00016","mag":"2013682277","pmid":"https://pubmed.ncbi.nlm.nih.gov/9771845"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199809270-00016","doi":"https://doi.org/10.1097/00007890-199809270-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199809270-00016","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059077667","display_name":"Ronald J. Torry","orcid":"https://orcid.org/0000-0001-9875-6671","observed_orcids":["https://orcid.org/0000-0001-9875-6671"]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald J. Torry","raw_affiliation_strings":["Methodist Research Institute, Clarian Health, Inc., Indianapolis, Indiana 46202, USA","Dr. Ronald J. Torry, Methodist Research Institute, Clarian Health, Inc., 116 Wile Hall, 1701 North Senate Boulevard, Indianapolis, IN 46202","Methodist Research Institute, Clarian Health, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist Research Institute, Clarian Health, Inc., Indianapolis, Indiana 46202, USA","institution_ids":["https://openalex.org/I1283055418"]},{"raw_affiliation_string":"Dr. Ronald J. Torry, Methodist Research Institute, Clarian Health, Inc., 116 Wile Hall, 1701 North Senate Boulevard, Indianapolis, IN 46202","institution_ids":["https://openalex.org/I1283055418"]},{"raw_affiliation_string":"Methodist Research Institute, Clarian Health, Inc","institution_ids":["https://openalex.org/I1283055418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112524626","display_name":"Carlos Alberto Labarrere","orcid":"https://orcid.org/0000-0001-8388-6318","observed_orcids":["https://orcid.org/0000-0001-8388-6318"]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Labarrere","raw_affiliation_strings":["Methodist Research Institute, Clarian Health, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist Research Institute, Clarian Health, Inc","institution_ids":["https://openalex.org/I1283055418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015873957","display_name":"David R. Nelson","orcid":"https://orcid.org/0000-0002-3240-0725","observed_orcids":["https://orcid.org/0000-0002-3240-0725"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Nelson","raw_affiliation_strings":["Current affiliation: Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current affiliation: Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012477724","display_name":"CHARLES B. CARTER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Carter","raw_affiliation_strings":["Methodist Hospital, Transplantation Department, Clarian Health, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist Hospital, Transplantation Department, Clarian Health, Inc","institution_ids":["https://openalex.org/I1283055418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036761043","display_name":"Brian W. Haag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Haag","raw_affiliation_strings":["Methodist Hospital, Transplantation Department, Clarian Health, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist Hospital, Transplantation Department, Clarian Health, Inc","institution_ids":["https://openalex.org/I1283055418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080513945","display_name":"W. Pag\u00e9 Faulk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Page Faulk","raw_affiliation_strings":["Methodist Research Institute, Clarian Health, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Methodist Research Institute, Clarian Health, Inc","institution_ids":["https://openalex.org/I1283055418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059077667"],"corresponding_institution_ids":["https://openalex.org/I1283055418"],"apc_list":null,"apc_paid":null,"fwci":1.7323,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83978957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"6","first_page":"797","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9509999752044678},{"id":"https://openalex.org/keywords/renal-allograft-function","display_name":"renal allograft function","score":0.9079999923706055},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/graft-dysfunction","display_name":"graft dysfunction","score":0.824999988079071},{"id":"https://openalex.org/keywords/proximal-tubular-epithelium","display_name":"proximal tubular epithelium","score":0.9480000138282776},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7089999914169312},{"id":"https://openalex.org/keywords/donor-kidney-biopsy","display_name":"donor kidney biopsy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.9310125708580017},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.8480326533317566},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.6319277286529541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5308265089988708},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4717612862586975},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4680943787097931},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.41207355260849},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39373964071273804},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38808727264404297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3654792606830597},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.22543108463287354}],"mesh":[{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019737","descriptor_name":"Transplants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007890-199809270-00016","doi":"https://doi.org/10.1097/00007890-199809270-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199809270-00016","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:9771845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9771845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1491650478","https://openalex.org/W2026371035","https://openalex.org/W2066597216","https://openalex.org/W2090773317","https://openalex.org/W2093189401","https://openalex.org/W2095957966","https://openalex.org/W2106352950","https://openalex.org/W2417316794","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2769308894","https://openalex.org/W2790836333","https://openalex.org/W2077657925","https://openalex.org/W2012336027","https://openalex.org/W2135105692","https://openalex.org/W2040781548","https://openalex.org/W2090773317","https://openalex.org/W4315702522","https://openalex.org/W2046159984","https://openalex.org/W1979903072"],"abstract_inverted_index":{"BACKGROUND:":[0],"Antithrombin":[1],"is":[2,20,35,136],"found":[3,71],"in":[4,39,42],"the":[5,27,74,120],"microvasculature":[6],"and":[7,11,60,99,143],"tubules":[8],"of":[9,17,32,113,122,150],"normal":[10,107],"transplanted":[12],"human":[13],"kidneys.":[14],"Although":[15],"depletion":[16,112],"vascular":[18],"antithrombin":[19,34,41,69,82,109,115,133],"associated":[21,137],"with":[22,79,106,119,138],"renal":[23],"allograft":[24],"dysfunction,":[25],"neither":[26],"distribution":[28],"nor":[29],"clinical":[30],"significance":[31],"tubular":[33,40,76,81,108,114,132],"known.":[36],"METHODS:":[37],"Changes":[38],"biopsy":[43],"specimens":[44],"(n=41)":[45],"obtained":[46],"from":[47],"donor":[48],"kidneys":[49],"at":[50,83,92,116,125,134,148],"transplantation":[51,84,117,135],"were":[52],"studied":[53],"immunohistochemically.":[54],"The":[55],"relationship":[56],"between":[57],"these":[58],"changes":[59],"subsequent":[61],"graft":[62,123,141],"function":[63],"was":[64,70],"analyzed.":[65],"RESULTS:":[66],"Granular":[67],"intracellular":[68],"only":[72],"within":[73],"proximal":[75],"epithelium.":[77],"Allografts":[78],"depleted":[80],"(n=20)":[85],"had":[86],"significantly":[87],"greater":[88],"plasma":[89],"creatinine":[90],"concentrations":[91],"posttransplant":[93],"days":[94,127],"3":[95,126],"(P":[96,101],"<":[97,102],"0.001)":[98],"5":[100],"0.03)":[103],"than":[104],"allografts":[105],"(n=21).":[110],"Indeed,":[111],"correlated":[118],"degree":[121],"dysfunction":[124],"after":[128],"transplantation.":[129],"CONCLUSIONS:":[130],"Depleted":[131],"reduced":[139],"early":[140],"function,":[142],"this":[144],"may":[145],"identify":[146],"patients":[147],"risk":[149],"a":[151],"complicated":[152],"follow-up.":[153]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}