{"id":"https://openalex.org/W2013680730","doi":"https://doi.org/10.3324/haematol.2010.023358","title":"Lack of expression of inhibitory KIR3DL1 receptor in patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes","display_name":"Lack of expression of inhibitory KIR3DL1 receptor in patients with natural killer cell-type lymphoproliferative disease of granular lymphocytes","publication_year":2010,"publication_date":"2010-04-21","ids":{"openalex":"https://openalex.org/W2013680730","doi":"https://doi.org/10.3324/haematol.2010.023358","mag":"2013680730","pmid":"https://pubmed.ncbi.nlm.nih.gov/20410181","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2948098"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2010.023358","doi":"https://doi.org/10.3324/haematol.2010.023358","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2010.023358","pdf_url":"https://haematologica.org/article/download/5757/27297","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://haematologica.org/article/download/5757/27297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029869734","display_name":"Cristina Gattazzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Gattazzo","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Padova, via Giustiniani 2, Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Padova, via Giustiniani 2, Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085837784","display_name":"Antonella Teramo","orcid":"https://orcid.org/0000-0002-2754-699X","observed_orcids":["https://orcid.org/0000-0002-2754-699X"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Teramo","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000434082","display_name":"Marta Miorin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Miorin","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055410389","display_name":"Elisa Scquizzato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Scquizzato","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002636444","display_name":"Anna Cabrelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Cabrelle","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022506119","display_name":"Maria Luisa Balsamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Balsamo","raw_affiliation_strings":["Dipartimento di Medicina Sperimentale (DIMES) Universit\u00e0 di Genova , and Centro di Eccellenza per la Ricerca Biomedica , Genova , Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Sperimentale (DIMES) Universit\u00e0 di Genova , and Centro di Eccellenza per la Ricerca Biomedica , Genova , Italy","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011398547","display_name":"Carlo Agostini","orcid":"https://orcid.org/0000-0001-7786-3574","observed_orcids":["https://orcid.org/0000-0001-7786-3574"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Agostini","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063585187","display_name":"Elena Vendrame","orcid":"https://orcid.org/0000-0002-5595-1773","observed_orcids":["https://orcid.org/0000-0002-5595-1773"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Vendrame","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042259231","display_name":"Monica Facco","orcid":"https://orcid.org/0000-0003-0100-5789","observed_orcids":["https://orcid.org/0000-0003-0100-5789"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Facco","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058322220","display_name":"M. P. Albergoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. P. Albergoni","raw_affiliation_strings":["Blood Transfusion Service , University of Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Transfusion Service , University of Padova , Italy, and","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013236194","display_name":"Livio Trentin","orcid":"https://orcid.org/0000-0003-1222-6149","observed_orcids":["https://orcid.org/0000-0003-1222-6149"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Trentin","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068187248","display_name":"Massimo Vitale","orcid":"https://orcid.org/0000-0001-5372-7885","observed_orcids":["https://orcid.org/0000-0001-5372-7885"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Vitale","raw_affiliation_strings":["Istituto Nazionale per la Ricerca sul Cancro , S.C. Immunologia , Genova ;","A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale per la Ricerca sul Cancro , S.C. Immunologia , Genova ;","institution_ids":[]},{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087722204","display_name":"Gianpietro Semenzato","orcid":"https://orcid.org/0000-0002-6061-4595","observed_orcids":["https://orcid.org/0000-0002-6061-4595"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Semenzato","raw_affiliation_strings":["Department of Clinical and Experimental Medicine , University of Padova , via Giustiniani 2 , 35128 Padova , Italy","Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine , University of Padova , via Giustiniani 2 , 35128 Padova , Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066814162","display_name":"Renato Zambello","orcid":"https://orcid.org/0000-0002-8799-5324","observed_orcids":["https://orcid.org/0000-0002-8799-5324"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]},{"id":"https://openalex.org/I4210087465","display_name":"Veneto Institute of Molecular Medicine","ror":"https://ror.org/0048jxt15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087465"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Zambello","raw_affiliation_strings":["Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Padova University School of Medicine , Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch , Venetian Institute for Molecular Medicine , Padova , Italy, and","institution_ids":["https://openalex.org/I138689650","https://openalex.org/I4210087465"]},{"raw_affiliation_string":"University of Padova","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":1.2363,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77524351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"10","first_page":"1722","last_page":"1729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kir3dl1","display_name":"KIR3DL1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/kir3ds1","display_name":"KIR3DS1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.847000002861023},{"id":"https://openalex.org/keywords/nk-cell-receptor-expression","display_name":"NK cell receptor expression","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6019850373268127},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5688530206680298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5681392550468445},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5622861385345459},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.5067482590675354},{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.4852859675884247},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4629074037075043},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42972123622894287},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4281383752822876},{"id":"https://openalex.org/C2993002077","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Receptor expression","level":3,"score":0.4271780550479889},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4203379154205322},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3415125906467438},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3238869905471802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.290942907333374},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2599267065525055},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22891417145729065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22069919109344482},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.17676901817321777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15337610244750977},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.1420038342475891},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054066","descriptor_name":"Leukemia, Large Granular Lymphocytic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054341","descriptor_name":"Receptors, KIR3DL1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D054341","descriptor_name":"Receptors, KIR3DL1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054349","descriptor_name":"Receptors, KIR3DS1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3324/haematol.2010.023358","doi":"https://doi.org/10.3324/haematol.2010.023358","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2010.023358","pdf_url":"https://haematologica.org/article/download/5757/27297","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2948098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2948098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmid:20410181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20410181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1e2bcf1a33e44bc6a75376604f0aed80","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1e2bcf1a33e44bc6a75376604f0aed80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 95, Iss 10 (2010)","raw_type":"article"},{"id":"pmh:oai:www.research.unipd.it:11577/2475763","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11577/2475763","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2010.023358","doi":"https://doi.org/10.3324/haematol.2010.023358","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2010.023358","pdf_url":"https://haematologica.org/article/download/5757/27297","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320326074","display_name":"Regione del Veneto","ror":"https://ror.org/03mm67z69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013680730.pdf","grobid_xml":"https://content.openalex.org/works/W2013680730.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W153695106","https://openalex.org/W250756067","https://openalex.org/W1480061065","https://openalex.org/W1524049020","https://openalex.org/W1524920591","https://openalex.org/W1556867369","https://openalex.org/W1575740895","https://openalex.org/W1577875429","https://openalex.org/W1719540238","https://openalex.org/W1791206282","https://openalex.org/W1833097059","https://openalex.org/W1967863146","https://openalex.org/W1969814796","https://openalex.org/W1972494701","https://openalex.org/W1974008017","https://openalex.org/W1974318598","https://openalex.org/W1990569845","https://openalex.org/W1994232628","https://openalex.org/W2002926022","https://openalex.org/W2003882269","https://openalex.org/W2008731424","https://openalex.org/W2015719801","https://openalex.org/W2019333599","https://openalex.org/W2022113801","https://openalex.org/W2029169197","https://openalex.org/W2039497150","https://openalex.org/W2045821528","https://openalex.org/W2062581776","https://openalex.org/W2081246637","https://openalex.org/W2095392967","https://openalex.org/W2105517056","https://openalex.org/W2110036277","https://openalex.org/W2121417064","https://openalex.org/W2124603532","https://openalex.org/W2125645556","https://openalex.org/W2130649175","https://openalex.org/W2151304598","https://openalex.org/W2160520392","https://openalex.org/W2167172107","https://openalex.org/W2172005924","https://openalex.org/W2172180689","https://openalex.org/W2210620858","https://openalex.org/W2230246453","https://openalex.org/W2354344320","https://openalex.org/W2405099813","https://openalex.org/W2413014369"],"related_works":["https://openalex.org/W1833097059","https://openalex.org/W2151304598","https://openalex.org/W2008857724","https://openalex.org/W2045821528","https://openalex.org/W2314405812","https://openalex.org/W75091622","https://openalex.org/W2991964613","https://openalex.org/W2291359029","https://openalex.org/W7049041786","https://openalex.org/W1977912437"],"abstract_inverted_index":{"BACKGROUND:":[0],"Natural":[1],"killer":[2,30,37,59,99,258],"cell-type":[3,60,100,259],"lymphoproliferative":[4,43,61,101,260],"disease":[5,62,102,261],"of":[6,16,63,84,103,120,130,135,146,152,157,161,185,187,219,228,239,244,256,262],"granular":[7,18,64,104,263],"lymphocytes":[8,65,105],"is":[9],"a":[10,27,165,216,251],"disorder":[11],"characterized":[12,70],"by":[13,71],"chronic":[14],"proliferation":[15],"CD3(-)CD16(+)":[17],"lymphocytes.":[19,264],"By":[20],"flow":[21],"cytometry":[22],"analysis,":[23],"we":[24,210],"previously":[25],"demonstrated":[26,126],"dysregulation":[28],"in":[29,35,94,107,117,133,144,150,174,177,253],"immunoglobulin-like":[31],"receptor":[32,141],"(KIR)":[33],"expression":[34,132,186,238],"natural":[36,58,98,257],"cells":[38],"from":[39],"patients":[40,56,96,137,147,175,203],"with":[41,57,97,139,235],"this":[42,208],"disease,":[44],"the":[45,81,85,89,118,121,127,136,140,158,193,213,220,236,242,245,254],"activating":[46,73,92,240],"KIR":[47,68,74],"receptors":[48,93],"being":[49,142],"mostly":[50],"expressed.":[51],"We":[52,79,125],"also":[53,249],"found":[54],"that":[55,233],"usually":[66,113],"had":[67],"genotypes":[69],"multiple":[72],"genes.":[75],"DESIGN":[76],"AND":[77],"METHODS:":[78],"investigated":[80],"mRNA":[82],"levels":[83,184],"KIR3DL1":[86,131,162,222],"inhibitory":[87,221,246],"and":[88,106,204],"related":[90],"KIR3DS1":[91],"15":[95],"ten":[108],"controls.":[109,205],"These":[110],"genes":[111],"are":[112,192],"expressed":[114,143],"when":[115],"present":[116],"genome":[119],"Caucasian":[122],"population.":[123],"RESULTS:":[124],"complete":[128],"lack":[129,243],"most":[134],"analyzed,":[138],"13%":[145],"compared":[148],"to":[149,225],"90%":[151],"controls":[153],"(P<0.01).":[154],"Interestingly,":[155],"studies":[156],"methylation":[159,168,227],"patterns":[160],"promoter":[163],"showed":[164],"significantly":[166],"higher":[167],"status":[169],"(0.76":[170],"\u00b1":[171],"0.12":[172],"SD)":[173],"than":[176],"healthy":[178],"subjects":[179],"(0.49\u00b10.10":[180],"SD,":[181],"P<0.01).":[182],"The":[183],"DNA":[188,197],"methyl":[189],"transferases,":[190],"which":[191],"enzymes":[194],"responsible":[195],"for":[196,212],"methylation,":[198],"did":[199],"not":[200],"differ":[201],"between":[202],"CONCLUSIONS:":[206],"In":[207],"study":[209],"showed,":[211],"first":[214],"time,":[215],"consistent":[217],"down-regulation":[218],"signal":[223,247],"due":[224],"marked":[226],"its":[229],"promoter,":[230],"thus":[231],"suggesting":[232],"together":[234],"increased":[237],"receptors,":[241],"could":[248],"play":[250],"role":[252],"pathogenesis":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
