{"id":"https://openalex.org/W2013663896","doi":"https://doi.org/10.1210/en.137.3.975","title":"Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells","display_name":"Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2013663896","doi":"https://doi.org/10.1210/en.137.3.975","mag":"2013663896","pmid":"https://pubmed.ncbi.nlm.nih.gov/8603611"},"language":"en","primary_location":{"id":"doi:10.1210/en.137.3.975","doi":"https://doi.org/10.1210/en.137.3.975","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.3.975","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041502555","display_name":"Yue Zhou","orcid":"https://orcid.org/0009-0002-5100-1516","observed_orcids":["https://orcid.org/0009-0002-5100-1516"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Zhou","raw_affiliation_strings":["J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Mohan","raw_affiliation_strings":["J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029876277","display_name":"Thomas A. Linkhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T A Linkhart","raw_affiliation_strings":["J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024383216","display_name":"David J. Baylink","orcid":"https://orcid.org/0000-0001-8937-5623","observed_orcids":["https://orcid.org/0000-0001-8937-5623"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Baylink","raw_affiliation_strings":["J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009557449","display_name":"Donna D. Strong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D D Strong","raw_affiliation_strings":["J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. L. Pettis Memorial Veterans Hospital, Loma Linda University, California 92357, USA","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210116750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.6786,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.97610294,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"137","issue":"3","first_page":"975","last_page":"983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.9789999723434448},{"id":"https://openalex.org/keywords/igfbp-5","display_name":"IGFBP-5","score":0.8679999709129333},{"id":"https://openalex.org/keywords/igfbp-6","display_name":"IGFBP-6","score":1.0},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9150000214576721},{"id":"https://openalex.org/keywords/igfbp-4","display_name":"IGFBP-4","score":1.0},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bone-cell-differentiation","display_name":"bone cell differentiation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7549999952316284},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8479999899864197},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/u2os-cells","display_name":"U2OS cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.777545690536499},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7551571130752563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7342054843902588},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.6984439492225647},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6240094304084778},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5852708220481873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5806750655174255},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5795658826828003},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.4641384482383728},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.4521009922027588},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.435815691947937},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4176887273788452},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.2918378710746765},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.268587589263916},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.23439037799835205},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11160454154014587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11135357618331909},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11050832271575928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1055208146572113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007641","descriptor_name":"Keratolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.137.3.975","doi":"https://doi.org/10.1210/en.137.3.975","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.137.3.975","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.137.3.8603611","doi":"https://doi.org/10.1210/endo.137.3.8603611","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.137.3.8603611","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:8603611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2494010510","display_name":"Endosteal Bone Volume Regulation and Osteoporosis","funder_award_id":"R01AR031062","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G500157944","display_name":null,"funder_award_id":"AR 31062","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310839","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W112681758","https://openalex.org/W1485254412","https://openalex.org/W1487784157","https://openalex.org/W2072462218","https://openalex.org/W2086722866","https://openalex.org/W2091246953","https://openalex.org/W2111144542","https://openalex.org/W2134812217","https://openalex.org/W2137848171","https://openalex.org/W2156423290"],"related_works":["https://openalex.org/W3036293198","https://openalex.org/W2082902430","https://openalex.org/W2057096704","https://openalex.org/W2068431088","https://openalex.org/W2170155193","https://openalex.org/W2019700290","https://openalex.org/W1966632103","https://openalex.org/W2063934012","https://openalex.org/W1977466444","https://openalex.org/W2037326840"],"abstract_inverted_index":{"Retinoic":[0],"acid":[1],"(RA)":[2],"regulates":[3,353],"the":[4,52,71,89,125,163,192,204,218,230,250,256,267,277,281,287,295,302,306,314,318],"growth":[5,26],"and":[6,12,37,39,83,155,160,176,185,197,236,272,330],"differentiation":[7,38],"of":[8,33,73,91,104,124,142,147,162,191,207,220,249,258,289],"numerous":[9],"cells":[10,61],"types":[11,111],"plays":[13],"a":[14],"key":[15],"role":[16],"in":[17,62,78,96,108,167,180,203,233,270,280,286,297,305,317,328,335,341,356],"skeletal":[18],"development.":[19],"Previous":[20],"studies":[21],"have":[22],"demonstrated":[23],"that":[24,40,54,324],"insulin-like":[25],"factors":[27],"(IGFs)":[28],"are":[29],"important":[30],"local":[31],"regulators":[32],"bone":[34,60,182],"cell":[35,110],"proliferation":[36],"IGF-binding":[41],"proteins":[42],"(IGFBPs)":[43],"modulate":[44],"their":[45],"activities.":[46],"In":[47,149,300,349],"an":[48],"attempt":[49],"to":[50,88,114,140,158,195,199,266,294],"test":[51],"hypothesis":[53],"RA":[55,74,92,105,253,290,325,351],"mediates":[56],"its":[57],"effects":[58,90,129,173],"on":[59,75,93,106,130,174],"part":[63,336],"by":[64,213,226,339],"regulating":[65],"IGFBP":[66,76,94,261,354],"expression,":[67],"we":[68],"first":[69],"examined":[70],"effect":[72,103],"expression":[77,95,355],"human":[79,97,181,186,357],"osteoblast":[80,358],"model":[81],"systems":[82],"then":[84],"compared":[85],"these":[86],"responses":[87],"skin":[98,187],"fibroblasts.":[99,188],"The":[100,189],"most":[101],"dramatic":[102],"IGFBPs++":[107],"all":[109,259],"tested":[112],"was":[113,222],"increase":[115,232,279,304,316],"IGFBP-6":[116,234,307],"messenger":[117],"RNA":[118,151],"(mRNA)":[119],"abundance":[120,133],"more":[121],"than":[122],"1000%":[123],"control":[126,143,164],"value.":[127],"Significant":[128],"IGFBP-5":[131,221,239,282,329],"mRNA":[132,157,178,235,240,247,274,283,298,308,319,332],"were":[134],"also":[135],"found,":[136],"with":[137],"maximal":[138],"reductions":[139],"35%":[141],"within":[144],"24":[145],"h":[146],"treatment.":[148],"addition,":[150,301],"maximally":[152],"increased":[153,255],"IGFBP-3":[154,175,271],"-4":[156,177],"580%":[159],"390%":[161],"value,":[165],"respectively,":[166],"SaOS-2":[168],"cells,":[169,183],"but":[170,242],"had":[171],"variable":[172],"levels":[179,190,248,333],"U2-OS,":[184],"24-,":[193],"29-":[194],"32-,":[196],"38-":[198],"42":[200],"kDa":[201],"IGFBPs":[202],"conditioned":[205],"medium":[206],"RA-treated":[208],"cultures":[209],"increased,":[210],"as":[211,224],"determined":[212,225],"ligand":[214],"blot":[215],"analysis,":[216],"whereas":[217],"amount":[219],"reduced,":[223],"RIA.":[227],"Cycloheximide":[228],"abolished":[229],"RA-stimulated":[231],"reduced":[237],"baseline":[238],"levels,":[241],"did":[243],"not":[244,292,311],"affect":[245],"RA-modulated":[246],"other":[251,344],"IGFBPs.":[252],"modestly":[254],"stabilities":[257],"four":[260],"mRNAs,":[262],"which":[263],"could":[264,291,310],"contribute":[265,293],"observed":[268],"increases":[269],"IGFBP-4":[273],"levels;":[275],"however,":[276],"217%":[278],"half-":[284],"life":[285],"presence":[288],"reduction":[296],"levels.":[299],"small":[303],"half-life":[309],"account":[312],"for":[313],"1900%":[315],"level.":[320],"These":[321],"data":[322],"suggest":[323],"stimulated":[326],"changes":[327],"-6":[331],"may":[334],"be":[337],"mediated":[338],"alterations":[340],"transcription":[342],"or":[343],"early":[345],"posttranscription":[346],"regulatory":[347],"mechanisms.":[348],"conclusion,":[350],"significantly":[352],"cells.":[359]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
