{"id":"https://openalex.org/W2013646237","doi":"https://doi.org/10.1002/wrna.1113","title":"G\u2010quadruplexes in RNA biology","display_name":"G\u2010quadruplexes in RNA biology","publication_year":2012,"publication_date":"2012-04-03","ids":{"openalex":"https://openalex.org/W2013646237","doi":"https://doi.org/10.1002/wrna.1113","mag":"2013646237","pmid":"https://pubmed.ncbi.nlm.nih.gov/22488917"},"language":"en","primary_location":{"id":"doi:10.1002/wrna.1113","doi":"https://doi.org/10.1002/wrna.1113","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wrna.1113","pdf_url":null,"source":{"id":"https://openalex.org/S122939334","display_name":"Wiley Interdisciplinary Reviews - RNA","issn_l":"1757-7004","issn":["1757-7004","1757-7012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs RNA","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038041116","display_name":"Stefania Millevoi","orcid":"https://orcid.org/0000-0003-1659-3552","observed_orcids":["https://orcid.org/0000-0003-1659-3552"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210087620","display_name":"Centre de Recherches en Canc\u00e9rologie de Toulouse","ror":"https://ror.org/003412r28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Stefania Millevoi","raw_affiliation_strings":["Inserm UMR 1037, University of Toulouse III, Cancer Research Center of Toulouse, Toulouse 31432, Cedex 4, France. stefania.millevoi@inserm.fr","Inserm UMR 1037, University of Toulouse III, Cancer Research Center of Toulouse, Toulouse 31432, Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm UMR 1037, University of Toulouse III, Cancer Research Center of Toulouse, Toulouse 31432, Cedex 4, France. stefania.millevoi@inserm.fr","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Inserm UMR 1037, University of Toulouse III, Cancer Research Center of Toulouse, Toulouse 31432, Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091847535","display_name":"Herv\u00e9 Moine","orcid":"https://orcid.org/0000-0002-6250-7902","observed_orcids":["https://orcid.org/0000-0002-6250-7902"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Moine","raw_affiliation_strings":["Institut de Ge\u0301ne\u0301tique et Biologie Mole\u0301culaire et Cellulaire, CNRS, UMR 7104, INSERM, College de France, Universite\u0301 de Strasbourg, Illkirch Strasbourg, France","Institut de G\u00e9n\u00e9tique et Biologie Mol\u00e9culaire et Cellulaire, CNRS, UMR 7104, INSERM, College de France, Universit\u00e9 de Strasbourg, Illkirch Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Ge\u0301ne\u0301tique et Biologie Mole\u0301culaire et Cellulaire, CNRS, UMR 7104, INSERM, College de France, Universite\u0301 de Strasbourg, Illkirch Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique et Biologie Mol\u00e9culaire et Cellulaire, CNRS, UMR 7104, INSERM, College de France, Universit\u00e9 de Strasbourg, Illkirch Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081632204","display_name":"St\u00e9phan Vagner","orcid":"https://orcid.org/0000-0003-1452-7164","observed_orcids":["https://orcid.org/0000-0003-1452-7164"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phan Vagner","raw_affiliation_strings":["INSERM U981, Institut de cance\u0301rologie Gustave Roussy, Villejuif, France, Universite\u0301 Paris-Sud XI, Kremlin-Bice\u0302tre, France","INSERM U981, Institut de canc\u00e9rologie Gustave Roussy, Villejuif, France, Universit\u00e9 Paris\u2010Sud XI, Kremlin\u2010Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U981, Institut de cance\u0301rologie Gustave Roussy, Villejuif, France, Universite\u0301 Paris-Sud XI, Kremlin-Bice\u0302tre, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I154526488","https://openalex.org/I2801843802"]},{"raw_affiliation_string":"INSERM U981, Institut de canc\u00e9rologie Gustave Roussy, Villejuif, France, Universit\u00e9 Paris\u2010Sud XI, Kremlin\u2010Bic\u00eatre, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I154526488","https://openalex.org/I2801843802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5038041116"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210087620","https://openalex.org/I4405258862"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.0309,"has_fulltext":false,"cited_by_count":291,"citation_normalized_percentile":{"value":0.89975171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"3","issue":"4","first_page":"495","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-g-quadruplex","display_name":"RNA G-quadruplex","score":0.984000027179718},{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.8500000238418579},{"id":"https://openalex.org/keywords/telomere-homeostasis","display_name":"telomere homeostasis","score":0.906000018119812},{"id":"https://openalex.org/keywords/pre-mrna-processing","display_name":"pre-mRNA processing","score":0.8460000157356262},{"id":"https://openalex.org/keywords/splicing","display_name":"splicing","score":0.9610000252723694},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"polyadenylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rna-turnover","display_name":"RNA turnover","score":0.925000011920929},{"id":"https://openalex.org/keywords/mrna-targeting","display_name":"mRNA targeting","score":0.8220000267028809},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rna-metabolism","display_name":"RNA metabolism","score":0.5889999866485596},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7705539464950562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6800282001495361},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.5738558769226074},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5724825859069824},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.5559369921684265},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5186656713485718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4822043180465698},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4741372764110565},{"id":"https://openalex.org/C22232683","wikidata":"https://www.wikidata.org/wiki/Q417379","display_name":"Post-transcriptional modification","level":5,"score":0.44820642471313477},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4362056851387024},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.4295163154602051},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41200077533721924},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38368257880210876}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054856","descriptor_name":"G-Quadruplexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/wrna.1113","doi":"https://doi.org/10.1002/wrna.1113","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wrna.1113","pdf_url":null,"source":{"id":"https://openalex.org/S122939334","display_name":"Wiley Interdisciplinary Reviews - RNA","issn_l":"1757-7004","issn":["1757-7004","1757-7012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs RNA","raw_type":"journal-article"},{"id":"pmid:22488917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22488917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. RNA","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04311291v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04311291","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wiley Interdisciplinary Reviews-RNA, 2012, 3 (4), pp.495-507. ⟨10.1002/wrna.1113⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":115,"referenced_works":["https://openalex.org/W90439188","https://openalex.org/W1523125680","https://openalex.org/W1699609454","https://openalex.org/W1810809543","https://openalex.org/W1879167427","https://openalex.org/W1946213733","https://openalex.org/W1964177189","https://openalex.org/W1964578544","https://openalex.org/W1964680558","https://openalex.org/W1966163762","https://openalex.org/W1969117624","https://openalex.org/W1972962841","https://openalex.org/W1974568730","https://openalex.org/W1977504093","https://openalex.org/W1978547782","https://openalex.org/W1981232162","https://openalex.org/W1988267408","https://openalex.org/W1988900456","https://openalex.org/W1992274603","https://openalex.org/W1993738860","https://openalex.org/W1993864575","https://openalex.org/W1995987769","https://openalex.org/W1997836836","https://openalex.org/W1998846172","https://openalex.org/W2002664542","https://openalex.org/W2004459276","https://openalex.org/W2005788509","https://openalex.org/W2009351714","https://openalex.org/W2009581739","https://openalex.org/W2018172829","https://openalex.org/W2018676703","https://openalex.org/W2019097736","https://openalex.org/W2020679328","https://openalex.org/W2021978074","https://openalex.org/W2022188871","https://openalex.org/W2026279151","https://openalex.org/W2026370504","https://openalex.org/W2026657651","https://openalex.org/W2032698727","https://openalex.org/W2034558506","https://openalex.org/W2035809501","https://openalex.org/W2036399606","https://openalex.org/W2036593842","https://openalex.org/W2040481343","https://openalex.org/W2041737563","https://openalex.org/W2045830695","https://openalex.org/W2050913592","https://openalex.org/W2052309340","https://openalex.org/W2052326665","https://openalex.org/W2052370215","https://openalex.org/W2055557113","https://openalex.org/W2055583355","https://openalex.org/W2057544210","https://openalex.org/W2058920315","https://openalex.org/W2059306569","https://openalex.org/W2060017837","https://openalex.org/W2060215608","https://openalex.org/W2062779626","https://openalex.org/W2063361978","https://openalex.org/W2066055007","https://openalex.org/W2066332825","https://openalex.org/W2072971665","https://openalex.org/W2073204556","https://openalex.org/W2074613554","https://openalex.org/W2076124785","https://openalex.org/W2076843089","https://openalex.org/W2077205550","https://openalex.org/W2081027578","https://openalex.org/W2081565848","https://openalex.org/W2089608572","https://openalex.org/W2092238715","https://openalex.org/W2096795400","https://openalex.org/W2100440853","https://openalex.org/W2100959401","https://openalex.org/W2104629556","https://openalex.org/W2105879579","https://openalex.org/W2106231921","https://openalex.org/W2106774938","https://openalex.org/W2108966130","https://openalex.org/W2116166189","https://openalex.org/W2117834701","https://openalex.org/W2122100080","https://openalex.org/W2122141896","https://openalex.org/W2123107276","https://openalex.org/W2123724498","https://openalex.org/W2124166350","https://openalex.org/W2128133969","https://openalex.org/W2128398569","https://openalex.org/W2129429612","https://openalex.org/W2129522390","https://openalex.org/W2130652515","https://openalex.org/W2136471718","https://openalex.org/W2137474088","https://openalex.org/W2137986693","https://openalex.org/W2141344821","https://openalex.org/W2142075669","https://openalex.org/W2147529541","https://openalex.org/W2147643191","https://openalex.org/W2149174578","https://openalex.org/W2150636365","https://openalex.org/W2151639461","https://openalex.org/W2152120196","https://openalex.org/W2161887614","https://openalex.org/W2163533539","https://openalex.org/W2165954869","https://openalex.org/W2167086055","https://openalex.org/W2168146598","https://openalex.org/W2168558973","https://openalex.org/W2169230340","https://openalex.org/W2169745877","https://openalex.org/W2171928459","https://openalex.org/W2172154992","https://openalex.org/W2315475605","https://openalex.org/W4234191719","https://openalex.org/W4249990860"],"related_works":["https://openalex.org/W2972734466","https://openalex.org/W2166227297","https://openalex.org/W4388307894","https://openalex.org/W2161638311","https://openalex.org/W2895989095","https://openalex.org/W1989130122","https://openalex.org/W2528320810","https://openalex.org/W4411975226","https://openalex.org/W3012948147","https://openalex.org/W2548306987"],"abstract_inverted_index":{"Abstract":[0],"G\u2010quadruplexes":[1,26,45,65,88,121],"are":[2,27],"noncanonical":[3],"structures":[4],"formed":[5],"by":[6,86],"G\u2010rich":[7],"DNA":[8],"and":[9,20,40,60,74,80,158,172],"RNA":[10,25,44,64,76,87,123,137,146,156,163,168],"sequences":[11,36],"that":[12,24,95],"fold":[13],"into":[14],"a":[15,102],"four\u2010stranded":[16],"conformation.":[17],"Experimental":[18],"studies":[19],"computational":[21],"predictions":[22],"show":[23],"present":[28],"in":[29,34,53,122,136,140,165],"transcripts":[30,39],"associated":[31],"with":[32,125,170],"telomeres,":[33],"noncoding":[35],"of":[37,70,92,120,162],"primary":[38],"within":[41],"mature":[42],"transcripts.":[43],"at":[46],"these":[47],"specific":[48,134],"locations":[49],"play":[50],"important":[51,68],"roles":[52],"key":[54],"cellular":[55],"functions,":[56],"including":[57],"telomere":[58],"homeostasis":[59],"gene":[61],"expression.":[62],"Indeed,":[63],"appear":[66],"as":[67,101],"regulators":[69],"pre\u2010mRNA":[71],"processing":[72],"(splicing":[73],"polyadenylation),":[75],"turnover,":[77],"mRNA":[78],"targeting":[79],"translation.":[81],"The":[82],"regulatory":[83],"mechanisms":[84,131],"controlled":[85],"involve":[89],"the":[90,114,118,129],"binding":[91],"protein":[93,107],"factors":[94],"modulate":[96],"G\u2010quadruplex":[97],"conformation":[98],"and/or":[99],"serve":[100],"bridge":[103],"to":[104],"recruit":[105],"additional":[106],"regulators.":[108],"In":[109],"this":[110],"review,":[111],"we":[112],"summarize":[113],"current":[115],"knowledge":[116],"on":[117,128],"role":[119],"biology":[124],"particular":[126],"emphasis":[127],"molecular":[130],"underlying":[132],"their":[133],"function":[135],"metabolism":[138],"occurring":[139],"physiological":[141],"or":[142],"pathological":[143],"conditions.":[144],"WIREs":[145],"2012,":[147],"3:495\u2013507.":[148],"doi:":[149],"10.1002/wrna.1113":[150],"This":[151],"article":[152],"is":[153],"categorized":[154],"under:":[155],"Structure":[157,164],"Dynamics":[159],">":[160,175],"Influence":[161],"Biological":[166],"Systems":[167],"Interactions":[169],"Proteins":[171],"Other":[173],"Molecules":[174],"Protein\u2013RNA":[176],"Interactions:":[177],"Functional":[178],"Implications":[179]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}