{"id":"https://openalex.org/W2013629596","doi":"https://doi.org/10.1073/pnas.76.2.736","title":"Origin and direction of DNA replication of plasmid RSF1030.","display_name":"Origin and direction of DNA replication of plasmid RSF1030.","publication_year":1979,"publication_date":"1979-02-01","ids":{"openalex":"https://openalex.org/W2013629596","doi":"https://doi.org/10.1073/pnas.76.2.736","mag":"2013629596","pmid":"https://pubmed.ncbi.nlm.nih.gov/370835","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/383035"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.76.2.736","doi":"https://doi.org/10.1073/pnas.76.2.736","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.76.2.736","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC383035","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113764487","display_name":"Susan E. Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Conrad","raw_affiliation_strings":["California  Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California  Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107498994","display_name":"Marc S. Wold","orcid":"https://orcid.org/0000-0002-4580-1624","observed_orcids":["https://orcid.org/0000-0002-4580-1624"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Wold","raw_affiliation_strings":["California  Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California  Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000378293","display_name":"Judith L. Campbell","orcid":"https://orcid.org/0000-0001-8291-5551","observed_orcids":["https://orcid.org/0000-0001-8291-5551"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Campbell","raw_affiliation_strings":["California  Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California  Institute of Technology","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":null,"apc_paid":null,"fwci":3.1021,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.91679977,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76","issue":"2","first_page":"736","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-origins","display_name":"origin of replication","score":0.7720000147819519},{"id":"https://openalex.org/keywords/unidirectional-replication","display_name":"unidirectional replication","score":0.7919999957084656},{"id":"https://openalex.org/keywords/replication-intermediates","display_name":"replication intermediates","score":0.8370000123977661},{"id":"https://openalex.org/keywords/in-vitro-replication-system","display_name":"in vitro replication system","score":0.6620000004768372},{"id":"https://openalex.org/keywords/physical-map","display_name":"physical map","score":0.5740000009536743},{"id":"https://openalex.org/keywords/restriction-mapping","display_name":"restriction mapping","score":0.4560000002384186},{"id":"https://openalex.org/keywords/circular-dna","display_name":"circular DNA","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C42174275","wikidata":"https://www.wikidata.org/wiki/Q409191","display_name":"BamHI","level":4,"score":0.9223251342773438},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.658829391002655},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6324209570884705},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6040207743644714},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5951757431030273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5630725026130676},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.5433919429779053},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.4612272083759308},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.45311060547828674},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.4168117344379425},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41000285744667053},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38324427604675293},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.045810550451278687}],"mesh":[{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.76.2.736","doi":"https://doi.org/10.1073/pnas.76.2.736","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.76.2.736","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:63317","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC383035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:370835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/370835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:383035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC383035/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:58798","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/58798/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:63317","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC383035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1489410460","https://openalex.org/W1543014091","https://openalex.org/W1557147100","https://openalex.org/W1619545863","https://openalex.org/W1858120728","https://openalex.org/W2010531901","https://openalex.org/W2023617715","https://openalex.org/W2043860143","https://openalex.org/W2049502499","https://openalex.org/W2068901141","https://openalex.org/W2080043652","https://openalex.org/W2082043114","https://openalex.org/W2094995005","https://openalex.org/W2107834929","https://openalex.org/W4210974853"],"related_works":["https://openalex.org/W1977909703","https://openalex.org/W1561310770","https://openalex.org/W1619545863","https://openalex.org/W1547421960","https://openalex.org/W1543014091","https://openalex.org/W2131865558","https://openalex.org/W2029219293","https://openalex.org/W1967527813","https://openalex.org/W1994485364","https://openalex.org/W2049147540"],"abstract_inverted_index":{"An":[0],"in":[1,35,56,58,73,111,130,162,173],"vitro":[2,59,131,174],"replication":[3,15,155,208],"system":[4],"has":[5,156,190],"been":[6,157,191,210],"used":[7],"to":[8,66,70,179,213],"study":[9],"the":[10,17,43,52,57,106,148,160,164,194,203,214],"origin":[11,135,204],"and":[12,80,145,200,202,205],"direction":[13,206],"of":[14,16,22,45,54,109,116,141,154,168,188,207],"covalently":[18],"closed,":[19],"circular":[20],"DNA":[21,170],"plasmid":[23],"RSF1030,":[24],"a":[25,78,102,133,185],"nonconjugative":[26],"R":[27],"factor.":[28],"We":[29],"have":[30,64,209],"enriched":[31],"for":[32,83],"replicative":[33,89],"intermediates":[34,90,118],"these":[36],"studies":[37],"either":[38,121],"by":[39,50,159],"isolating":[40,84],"them":[41],"on":[42],"basis":[44],"their":[46],"unique":[47,134],"structure":[48],"or":[49,124],"limiting":[51],"extent":[53,108],"synthesis":[55,110,176],"system.":[60],"Circular":[61],"molecules":[62,144],"that":[63,98,104,127],"replicated":[65,86],"various":[67,180],"extents":[68,181],"migrate":[69],"characteristic":[71],"positions":[72],"agarose":[74],"gels,":[75],"thus":[76],"providing":[77],"rapid":[79],"efficient":[81],"method":[82],"partially":[85],"forms.":[87],"Alternatively,":[88],"can":[91],"be":[92],"isolated":[93],"directly":[94],"from":[95,132,138,147],"reaction":[96],"mixtures":[97],"contain":[99],"dideoxyTTP":[100],"(ddTTP),":[101],"compound":[103],"limits":[105],"average":[107],"vitro.":[112],"Electron":[113],"microscopic":[114],"analysis":[115],"such":[117],"linearized":[119],"with":[120,182],"Hpa":[122,142,198],"I":[123],"BamHI":[125,149],"indicates":[126],"RSF1030":[128,169,189],"replicates":[129],"located":[136],"70%":[137],"one":[139],"end":[140],"I-cleaved":[143],"47%":[146],"site.":[150],"The":[151],"unidirectional":[152],"mode":[153],"confirmed":[158],"order":[161],"which":[163],"six":[165],"HincII":[166],"fragments":[167],"are":[171],"labeled":[172],"when":[175],"is":[177],"limited":[178],"ddTTP.":[183],"Finally,":[184],"physical":[186],"map":[187],"constructed":[192],"using":[193],"restriction":[195],"endonucleases":[196],"BamHI,":[197],"I,":[199],"HincII,":[201],"defined":[211],"relative":[212],"map.":[215]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
