{"id":"https://openalex.org/W2013596633","doi":"https://doi.org/10.1002/elps.1150191424","title":"A comparison of liver protein changes in mice and hamsters treated with the peroxisome proliferator Wy\u201014,643","display_name":"A comparison of liver protein changes in mice and hamsters treated with the peroxisome proliferator Wy\u201014,643","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2013596633","doi":"https://doi.org/10.1002/elps.1150191424","mag":"2013596633","pmid":"https://pubmed.ncbi.nlm.nih.gov/9820974"},"language":"en","primary_location":{"id":"doi:10.1002/elps.1150191424","doi":"https://doi.org/10.1002/elps.1150191424","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.1150191424","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011452232","display_name":"Carol Smith Giometti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol S. Giometti","raw_affiliation_strings":["Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439, USA. csgiometti@anl.gov","Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439, USA. csgiometti@anl.gov","institution_ids":["https://openalex.org/I1282105669"]},{"raw_affiliation_string":"Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025508494","display_name":"Sandra L. Tollaksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra L. Tollaksen","raw_affiliation_strings":["Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076602159","display_name":"Xiaoli Liang","orcid":"https://orcid.org/0000-0002-8457-4233","observed_orcids":["https://orcid.org/0000-0002-8457-4233"]},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoli Liang","raw_affiliation_strings":["Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, Argonne, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043648150","display_name":"Michael L. Cunningham","orcid":"https://orcid.org/0000-0003-2277-654X","observed_orcids":["https://orcid.org/0000-0003-2277-654X"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Cunningham","raw_affiliation_strings":["National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011452232"],"corresponding_institution_ids":["https://openalex.org/I1282105669"],"apc_list":{"value":3940,"currency":"USD","value_usd":3940},"apc_paid":null,"fwci":0.5815,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.59038479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"19","issue":"14","first_page":"2498","last_page":"2505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wy-14643","display_name":"Wy-14,643","score":0.9919999837875366},{"id":"https://openalex.org/keywords/peroxisome-proliferators","display_name":"peroxisome proliferators","score":0.8759999871253967},{"id":"https://openalex.org/keywords/peroxisome-proliferation","display_name":"peroxisome proliferation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/species-differences","display_name":"species differences","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hamster","display_name":"hamster","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.8328617811203003},{"id":"https://openalex.org/C2910266098","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator","level":4,"score":0.7541625499725342},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.6667953729629517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5131586194038391},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.46958938241004944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4252578914165497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38614997267723083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3687310814857483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3313225507736206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19479525089263916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17134860157966614}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004746","descriptor_name":"Enoyl-CoA Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007535","descriptor_name":"Isomerases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015094","descriptor_name":"3-Hydroxyacyl CoA Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020025","descriptor_name":"Peroxisome Proliferators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063994","descriptor_name":"Peroxisomal Bifunctional Enzyme","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/elps.1150191424","doi":"https://doi.org/10.1002/elps.1150191424","is_oa":false,"landing_page_url":"https://doi.org/10.1002/elps.1150191424","pdf_url":null,"source":{"id":"https://openalex.org/S2849398","display_name":"Electrophoresis","issn_l":"0173-0835","issn":["0173-0835","1522-2683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ELECTROPHORESIS","raw_type":"journal-article"},{"id":"pmid:9820974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9820974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Electrophoresis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8565605234","display_name":null,"funder_award_id":"1-YOI ES-50262","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W275146305","https://openalex.org/W276108846","https://openalex.org/W310833919","https://openalex.org/W1541369085","https://openalex.org/W1551584577","https://openalex.org/W1606423922","https://openalex.org/W1979510066","https://openalex.org/W1985400591","https://openalex.org/W1996811903","https://openalex.org/W2002625548","https://openalex.org/W2018195903","https://openalex.org/W2018208434","https://openalex.org/W2030462329","https://openalex.org/W2047034629","https://openalex.org/W2070902312","https://openalex.org/W2082416572","https://openalex.org/W2083453910","https://openalex.org/W2104996921","https://openalex.org/W2118592957","https://openalex.org/W2119265707","https://openalex.org/W2142263261","https://openalex.org/W2219509325","https://openalex.org/W4323253937"],"related_works":["https://openalex.org/W310833919","https://openalex.org/W2069770191","https://openalex.org/W1985508094","https://openalex.org/W2018208434","https://openalex.org/W2119265707","https://openalex.org/W2179603149","https://openalex.org/W2340115439","https://openalex.org/W1993155910","https://openalex.org/W2042051262","https://openalex.org/W2023649220"],"abstract_inverted_index":{"Interspecies":[0],"differences":[1],"in":[2,12,27,38,60,107,139,148,158,169,179,190,204,213,242,256],"the":[3,28,32,39,92,115,136,155,166,205,218,243,263],"liver":[4,104,143,182,193,225,278],"response":[5,55,214,266],"to":[6,75,90,97,135,165,215,251,272,277],"Wy-14,643,":[7,216,252],"a":[8,50],"potent":[9],"peroxisome":[10,53,125,239,264],"proliferator":[11],"rats":[13,21],"and":[14,22,44,56,64,110,141,161,186,189,197,207,222,248,267],"mice,":[15,65],"have":[16,49],"been":[17,88],"demonstrated.":[18],"While":[19],"both":[20,159,246],"mice":[23,109,160,247],"show":[24,236],"dramatic":[25],"increases":[26],"number":[29],"of":[30,34,41,94,101,114,220,232,245,262],"peroxisomes,":[31],"activity":[33],"peroxisomal":[35],"enzymes":[36],"involved":[37],"beta-oxidation":[40],"fatty":[42],"acids,":[43],"heptocyte":[45],"replication,":[46],"Syrian":[47],"hamsters":[48,249],"more":[51,151],"moderate":[52],"proliferation":[54,240,265],"no":[57],"sustained":[58],"increase":[59],"cell":[61],"replication.":[62],"Rats":[63],"but":[66],"not":[67],"hamsters,":[68],"develop":[69],"hepatocellular":[70],"carcinoma":[71],"after":[72],"prolonged":[73],"exposure":[74,96],"Wy-14,643.":[76],"To":[77],"further":[78],"characterize":[79],"this":[80],"species":[81],"difference,":[82],"two-dimensional":[83],"gel":[84],"electrophoresis":[85],"(2-DE)":[86],"has":[87],"used":[89],"compare":[91],"effect":[93],"14-day":[95],"various":[98],"dietary":[99],"concentrations":[100],"Wy-14,643":[102],"on":[103],"protein":[105,117,144,226],"expression":[106],"male":[108],"hamsters.":[111,162],"Digitized":[112],"images":[113],"2-DE":[116,145],"maps":[118],"were":[119,177],"searched":[120],"for":[121],"significant":[122,171],"changes.":[123],"The":[124],"bifunctional":[126],"enzyme":[127],"(PBE)":[128],"enoyl":[129],"CoA":[130],"hydratase/3-hydroxyacyl":[131],"dehydrogenase,":[132],"which":[133],"migrates":[134],"same":[137],"position":[138],"mouse":[140,181,206],"hamster":[142,192,208],"patterns,":[146],"increased":[147],"abundance":[149],"by":[150],"than":[152],"three":[153],"times":[154],"control":[156],"level":[157],"In":[163],"addition":[164],"quantitative":[167,172,211],"change":[168],"PBE,":[170],"changes":[173,212,255],"(P":[174],"<":[175],"0.001)":[176],"found":[178],"49":[180],"proteins":[183,194,209,257],"(47":[184],"decreasing":[185,196],"2":[187],"increasing)":[188],"35":[191],"(27":[195],"8":[198],"increasing).":[199],"There":[200],"was":[201],"little":[202],"overlap":[203],"showing":[210],"with":[217,227],"exception":[219],"PBE":[221],"one":[223],"unidentified":[224],"an":[228],"approximate":[229],"molecular":[230],"weight":[231],"50,000.":[233],"These":[234],"results":[235],"that":[237,259,268],"although":[238],"occurs":[241],"livers":[244],"exposed":[250],"other":[253],"species-specific":[254,273],"occur":[258],"are":[260],"independent":[261],"could":[269],"be":[270],"related":[271],"susceptibility":[274],"or":[275],"resistance":[276],"tumor":[279],"induction.":[280]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}