{"id":"https://openalex.org/W2013586539","doi":"https://doi.org/10.1074/jbc.m609962200","title":"Pathogen Recognition by Toll-like Receptor 2 Activates Weibel-Palade Body Exocytosis in Human Aortic Endothelial Cells","display_name":"Pathogen Recognition by Toll-like Receptor 2 Activates Weibel-Palade Body Exocytosis in Human Aortic Endothelial Cells","publication_year":2007,"publication_date":"2007-01-17","ids":{"openalex":"https://openalex.org/W2013586539","doi":"https://doi.org/10.1074/jbc.m609962200","mag":"2013586539","pmid":"https://pubmed.ncbi.nlm.nih.gov/17227763"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m609962200","doi":"https://doi.org/10.1074/jbc.m609962200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609962200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m609962200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038725297","display_name":"Takeshi Into","orcid":"https://orcid.org/0000-0001-9411-9480","observed_orcids":["https://orcid.org/0000-0001-9411-9480"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]},{"id":"https://openalex.org/I4405286724","display_name":"Research Institute, National Center for Geriatrics and Gerontology","ror":"https://ror.org/02xbv4565","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Into","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan. into@nils.go.jp","Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan. into@nils.go.jp","institution_ids":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]},{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040680020","display_name":"Yosuke Kanno","orcid":"https://orcid.org/0000-0001-9741-2113","observed_orcids":["https://orcid.org/0000-0001-9741-2113","https://orcid.org/0000-0002-6003-5665"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Kanno","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054686476","display_name":"Junichi Dohkan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Dohkan","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479428","display_name":"Misako Nakashima","orcid":"https://orcid.org/0000-0002-1274-4483","observed_orcids":["https://orcid.org/0000-0002-1274-4483"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misako Nakashima","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014119193","display_name":"Megumi Inomata","orcid":"https://orcid.org/0000-0003-2409-2694","observed_orcids":["https://orcid.org/0000-0003-2409-2694"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Megumi Inomata","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019726395","display_name":"Kenichiro Shibata","orcid":"https://orcid.org/0000-0002-6497-9073","observed_orcids":["https://orcid.org/0000-0002-6497-9073"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichiro Shibata","raw_affiliation_strings":["Laboratory of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027355126","display_name":"Charles J. Lowenstein","orcid":"https://orcid.org/0000-0003-0485-7514","observed_orcids":["https://orcid.org/0000-0003-0485-7514"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles J. Lowenstein","raw_affiliation_strings":["Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101838189","display_name":"Kenji Matsushita","orcid":"https://orcid.org/0000-0003-2402-8633","observed_orcids":["https://orcid.org/0000-0003-2402-8633"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Matsushita","raw_affiliation_strings":["Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan","institution_ids":["https://openalex.org/I4210160102"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038725297"],"corresponding_institution_ids":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.874,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.9157235,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"282","issue":"11","first_page":"8134","last_page":"8141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aortic-endothelial-cells","display_name":"aortic endothelial cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lipoteichoic-acid","display_name":"lipoteichoic acid","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bacterial-lipopeptides","display_name":"bacterial lipopeptides","score":0.871999979019165},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.8309999704360962},{"id":"https://openalex.org/keywords/phospholipase-c-gamma","display_name":"phospholipase C-gamma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/innate-immune-recognition","display_name":"innate immune recognition","score":0.5170000195503235},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/laminar-flow","display_name":"laminar flow","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.8327150940895081},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5743516087532043},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5554559230804443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5408378839492798},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5143774151802063},{"id":"https://openalex.org/C2778025104","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll","level":2,"score":0.5143433809280396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4429941773414612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41238710284233093},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4030296206474304},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.27391737699508667},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26369696855545044},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.24353650212287903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12806841731071472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08298081159591675}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013682","descriptor_name":"Teichoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020302","descriptor_name":"Weibel-Palade Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020302","descriptor_name":"Weibel-Palade Bodies","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m609962200","doi":"https://doi.org/10.1074/jbc.m609962200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609962200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:17227763","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17227763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m609962200","doi":"https://doi.org/10.1074/jbc.m609962200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m609962200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W10482017","https://openalex.org/W98274933","https://openalex.org/W1503713311","https://openalex.org/W1567198647","https://openalex.org/W1580121471","https://openalex.org/W1596464709","https://openalex.org/W1613861112","https://openalex.org/W1652312395","https://openalex.org/W1699784618","https://openalex.org/W1733249062","https://openalex.org/W1768061198","https://openalex.org/W1897355343","https://openalex.org/W1912852347","https://openalex.org/W1978369960","https://openalex.org/W1984571968","https://openalex.org/W1989778393","https://openalex.org/W2004465286","https://openalex.org/W2013988304","https://openalex.org/W2014870509","https://openalex.org/W2017978377","https://openalex.org/W2033431538","https://openalex.org/W2041933511","https://openalex.org/W2042482956","https://openalex.org/W2043823247","https://openalex.org/W2065577350","https://openalex.org/W2069663822","https://openalex.org/W2072482524","https://openalex.org/W2074799449","https://openalex.org/W2075787525","https://openalex.org/W2079605309","https://openalex.org/W2079826979","https://openalex.org/W2081518693","https://openalex.org/W2086831409","https://openalex.org/W2088469326","https://openalex.org/W2091124904","https://openalex.org/W2091179088","https://openalex.org/W2092751085","https://openalex.org/W2108661081","https://openalex.org/W2109148136","https://openalex.org/W2111522106","https://openalex.org/W2114381030","https://openalex.org/W2115904774","https://openalex.org/W2118143284","https://openalex.org/W2120653802","https://openalex.org/W2124989653","https://openalex.org/W2127690345","https://openalex.org/W2132795628","https://openalex.org/W2139319526","https://openalex.org/W2140776090","https://openalex.org/W2145845079","https://openalex.org/W2147038697","https://openalex.org/W2149501430","https://openalex.org/W2157752762","https://openalex.org/W2170966854","https://openalex.org/W4247611694","https://openalex.org/W4296981756"],"related_works":["https://openalex.org/W2058872662","https://openalex.org/W2059213579","https://openalex.org/W2022694783","https://openalex.org/W68568482","https://openalex.org/W2119218397","https://openalex.org/W2092032357","https://openalex.org/W2162755344","https://openalex.org/W2047849679","https://openalex.org/W2364533564","https://openalex.org/W2091124904"],"abstract_inverted_index":{"The":[0],"endothelial":[1,42,58,187],"cell-specific":[2],"granule":[3],"Weibel-Palade":[4,77,98,157,190],"body":[5,78,99,158,191],"releases":[6],"vasoactive":[7],"substances":[8],"capable":[9],"of":[10,17,32,41,85,123,143,180,203],"modulating":[11],"vascular":[12,207],"inflammation.":[13,208],"Although":[14],"innate":[15,201],"recognition":[16,202],"pathogens":[18,46,205],"by":[19,81,150],"Toll-like":[20],"receptors":[21],"(TLRs)":[22],"is":[23],"thought":[24],"to":[25,44,61,75,206],"play":[26],"a":[27,102,173,181],"crucial":[28],"role":[29,175],"in":[30,178,185],"promotion":[31],"inflammatory":[33],"responses,":[34],"the":[35,86,144,168],"molecular":[36],"basis":[37],"for":[38,176,199],"early-phase":[39],"responses":[40],"cells":[43,59,188],"bacterial":[45,62,68,204],"has":[47],"not":[48,71],"fully":[49],"been":[50],"understood.":[51],"We":[52],"here":[53],"report":[54],"that":[55],"human":[56],"aortic":[57,186],"respond":[60],"lipoteichoic":[63],"acid":[64],"(LTA)":[65],"and":[66,92,104,121,139],"synthetic":[67],"lipopeptides,":[69],"but":[70],"lipopolysaccharide":[72],"or":[73,83,152],"peptidoglycan,":[74],"induce":[76],"exocytosis,":[79,159,192],"accompanied":[80],"release":[82],"externalization":[84],"storage":[87],"components":[88],"von":[89],"Willebrand":[90],"factor":[91],"P-selectin.":[93],"LTA":[94,127],"could":[95],"activate":[96],"rapid":[97],"exocytosis":[100,133],"through":[101,118,189],"TLR2-":[103],"MyD88-dependent":[105,119],"mechanism":[106],"without":[107],"de":[108,135],"novo":[109,136],"protein":[110,137],"synthesis.":[111],"This":[112],"process":[113],"was":[114],"at":[115],"least":[116],"mediated":[117],"phosphorylation":[120],"activation":[122,142],"phospholipase":[124,140],"Cgamma.":[125],"Moreover,":[126],"activated":[128],"interleukin-1":[129],"receptor-associated":[130],"kinase-1-dependent":[131],"delayed":[132],"with":[134],"synthesis":[138],"Cgamma-dependent":[141],"NF-kappaB":[145],"pathway.":[146],"Increased":[147],"TLR2":[148,162,177],"expression":[149,163],"transfection":[151],"interferon-gamma":[153],"treatment":[154],"increased":[155],"TLR2-mediated":[156],"whereas":[160],"reduced":[161],"under":[164],"laminar":[165],"flow":[166],"decreased":[167],"response.":[169],"Thus,":[170],"we":[171],"propose":[172],"novel":[174],"induction":[179],"primary":[182],"proinflammatory":[183],"event":[184],"which":[193],"may":[194],"be":[195],"an":[196],"important":[197],"step":[198],"linking":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
