{"id":"https://openalex.org/W2013580757","doi":"https://doi.org/10.1038/mt.2013.9","title":"The Use of Scaffold-free Cell Sheet Technique to Refine Mesenchymal Stromal Cell-based Therapy for Heart Failure","display_name":"The Use of Scaffold-free Cell Sheet Technique to Refine Mesenchymal Stromal Cell-based Therapy for Heart Failure","publication_year":2013,"publication_date":"2013-01-29","ids":{"openalex":"https://openalex.org/W2013580757","doi":"https://doi.org/10.1038/mt.2013.9","mag":"2013580757","pmid":"https://pubmed.ncbi.nlm.nih.gov/23358187","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3616531"},"language":"en","primary_location":{"id":"doi:10.1038/mt.2013.9","doi":"https://doi.org/10.1038/mt.2013.9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2013.9","pdf_url":"http://www.cell.com/article/S1525001616306608/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001616306608/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106083867","display_name":"Takuya Narita","orcid":"https://orcid.org/0009-0000-7595-662X","observed_orcids":["https://orcid.org/0009-0000-7595-662X"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Takuya Narita","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070603586","display_name":"Yasunori Shintani","orcid":"https://orcid.org/0000-0001-9579-0727","observed_orcids":["https://orcid.org/0000-0001-9579-0727"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yasunori Shintani","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076870479","display_name":"Chiho Ikebe","orcid":"https://orcid.org/0000-0001-9337-4404","observed_orcids":["https://orcid.org/0000-0001-9337-4404"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chiho Ikebe","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006626017","display_name":"Masahiro Kaneko","orcid":"https://orcid.org/0000-0002-8309-4086","observed_orcids":["https://orcid.org/0000-0002-8309-4086"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Masahiro Kaneko","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103235172","display_name":"Niall Gordon Simon Campbell","orcid":"https://orcid.org/0000-0003-4269-3848","observed_orcids":["https://orcid.org/0000-0003-4269-3848"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Niall G Campbell","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029347863","display_name":"Steven R. Coppen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven R Coppen","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085945815","display_name":"Rakesh Uppal","orcid":"https://orcid.org/0000-0003-0596-1129","observed_orcids":["https://orcid.org/0000-0003-0596-1129"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rakesh Uppal","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045683397","display_name":"Yoshiki Sawa","orcid":"https://orcid.org/0000-0001-6132-9684","observed_orcids":["https://orcid.org/0000-0001-6132-9684"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiki Sawa","raw_affiliation_strings":["Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044706706","display_name":"Kenta Yashiro","orcid":"https://orcid.org/0000-0002-2816-5662","observed_orcids":["https://orcid.org/0000-0002-2816-5662"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kenta Yashiro","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062288838","display_name":"Ken Suzuki","orcid":"https://orcid.org/0000-0002-8970-1553","observed_orcids":["https://orcid.org/0000-0002-8970-1553"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ken Suzuki","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]},{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062288838"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.6479,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.80353065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"21","issue":"4","first_page":"860","last_page":"867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9449999928474426},{"id":"https://openalex.org/keywords/paracrine-effects","display_name":"paracrine effects","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/intramyocardial-injection","display_name":"intramyocardial injection","score":0.9589999914169312},{"id":"https://openalex.org/keywords/coronary-artery-ligation","display_name":"coronary artery ligation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.503000020980835},{"id":"https://openalex.org/keywords/cell-retention","display_name":"cell retention","score":0.5049999952316284},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.9054636359214783},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.8932958841323853},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6422907114028931},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5727565884590149},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5420315265655518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5076402425765991},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4713924527168274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.425482839345932},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3655663728713989},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2902671694755554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24606773257255554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22344273328781128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17111825942993164},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10732966661453247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/mt.2013.9","doi":"https://doi.org/10.1038/mt.2013.9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2013.9","pdf_url":"http://www.cell.com/article/S1525001616306608/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2948719","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3616531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23358187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23358187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3616531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3616531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/mt.2013.9","doi":"https://doi.org/10.1038/mt.2013.9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2013.9","pdf_url":"http://www.cell.com/article/S1525001616306608/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4752720687","display_name":"Unipotency of Tbx5+ embryonic cardiac progenitor cells to cardiomyocytes.","funder_award_id":"MR/J007625/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8822737155","display_name":"\u2018Cell-sheet\u2019 therapy using allogeneic mesenchymal stem cells for ischaemic cardiomyopathy","funder_award_id":"PG/12/10/29389","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013580757.pdf","grobid_xml":"https://content.openalex.org/works/W2013580757.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W291413098","https://openalex.org/W1554555407","https://openalex.org/W1974815597","https://openalex.org/W1977950302","https://openalex.org/W1983517713","https://openalex.org/W2006444533","https://openalex.org/W2016289570","https://openalex.org/W2019755907","https://openalex.org/W2035582618","https://openalex.org/W2037244269","https://openalex.org/W2040489007","https://openalex.org/W2040644560","https://openalex.org/W2041360667","https://openalex.org/W2058021996","https://openalex.org/W2058944555","https://openalex.org/W2064990699","https://openalex.org/W2067591094","https://openalex.org/W2076837609","https://openalex.org/W2077885647","https://openalex.org/W2084372772","https://openalex.org/W2084693500","https://openalex.org/W2098520536","https://openalex.org/W2098849525","https://openalex.org/W2107577269","https://openalex.org/W2112777549","https://openalex.org/W2113619226","https://openalex.org/W2116446546","https://openalex.org/W2117412164","https://openalex.org/W2118402202","https://openalex.org/W2121166230","https://openalex.org/W2122059700","https://openalex.org/W2128484978","https://openalex.org/W2130527720","https://openalex.org/W2136071122","https://openalex.org/W2146223691","https://openalex.org/W2152338416","https://openalex.org/W2154580143","https://openalex.org/W2170675143","https://openalex.org/W2329405625"],"related_works":["https://openalex.org/W2171842","https://openalex.org/W1992138308","https://openalex.org/W2257669896","https://openalex.org/W2123389089","https://openalex.org/W2086409087","https://openalex.org/W2280726055","https://openalex.org/W3112034364","https://openalex.org/W2327360949","https://openalex.org/W3153506381","https://openalex.org/W2808578268"],"abstract_inverted_index":{"Transplantation":[0],"of":[1,22,32,55,63,87,105,121,151,166,200],"bone":[2],"marrow-derived":[3],"mesenchymal":[4],"stromal":[5],"cells":[6],"(MSCs)":[7],"is":[8,206],"an":[9],"emerging":[10],"treatment":[11],"for":[12],"heart":[13],"failure":[14],"based":[15],"on":[16,69,132],"their":[17],"secretion-mediated":[18],"\"paracrine":[19],"effects\".":[20],"Feasibility":[21],"the":[23,30,43,46,53,61,70,103,114,122,126,133,137,146,149,157,175],"scaffoldless":[24],"cell":[25,33,40,127],"sheet":[26,111,128,180,196],"technique":[27,58,129],"to":[28,59],"enhance":[29],"outcome":[31],"transplantation":[34,65],"has":[35],"been":[36],"reported":[37],"using":[38,91],"other":[39],"types,":[41],"though":[42],"mechanism":[44],"underpinning":[45],"enhancement":[47],"remains":[48],"uncertain.":[49],"We":[50],"here":[51],"investigated":[52],"role":[54],"this":[56,201],"innovative":[57],"amplify":[60],"effects":[62,186],"MSC":[64,88,110,179,195],"with":[66],"a":[67],"focus":[68],"underlying":[71],"factors.":[72],"After":[73],"coronary":[74],"artery":[75],"ligation":[76],"in":[77,174],"rats,":[78],"syngeneic":[79],"MSCs":[80,107,123,155],"were":[81,192],"grafted":[82,124],"by":[83,125,194],"either":[84],"epicardial":[85,134],"placement":[86,112],"sheets":[89],"generated":[90],"temperature-responsive":[92],"dishes":[93],"or":[94],"intramyocardial":[95],"(IM)":[96],"injection.":[97],"Markedly":[98],"increased":[99],"initial":[100],"retention":[101],"boosted":[102],"presence":[104],"donor":[106,115],"persistently":[108],"after":[109,178],"although":[113],"survival":[116],"was":[117,163],"not":[118],"improved.":[119],"Most":[120],"remained":[130],"resided":[131],"surface,":[135],"but":[136],"epicardium":[138],"quickly":[139],"regressed":[140],"and":[141,171,187],"new":[142],"vessels":[143],"sprouted":[144],"into":[145,156],"sheets,":[147],"assuring":[148],"permeation":[150],"paracrine":[152,168,185],"mediators":[153],"from":[154],"host":[158],"myocardium.":[159],"In":[160],"fact,":[161],"there":[162],"augmented":[164],"upregulation":[165],"various":[167],"effect-related":[169],"genes":[170],"signaling":[172],"pathways":[173],"early":[176],"phase":[177],"therapy.":[181,197],"Correspondingly,":[182],"more":[183],"extensive":[184],"resultant":[188],"cardiac":[189],"function":[190],"recovery":[191],"achieved":[193],"Further":[198],"development":[199],"approach":[202],"towards":[203],"clinical":[204],"application":[205],"encouraged.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
