{"id":"https://openalex.org/W2013570880","doi":"https://doi.org/10.1016/0163-7258(88)90113-1","title":"Environmental factors affecting drug metabolism","display_name":"Environmental factors affecting drug metabolism","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2013570880","doi":"https://doi.org/10.1016/0163-7258(88)90113-1","mag":"2013570880","pmid":"https://pubmed.ncbi.nlm.nih.gov/3277207"},"language":"en","primary_location":{"id":"doi:10.1016/0163-7258(88)90113-1","doi":"https://doi.org/10.1016/0163-7258(88)90113-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0163-7258(88)90113-1","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111969055","display_name":"John C. Mucklow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56007636","display_name":"Keele University","ror":"https://ror.org/00340yn33","country_code":"GB","type":"education","lineage":["https://openalex.org/I56007636"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J.C. Mucklow","raw_affiliation_strings":["Department of Postgraduate Medicine, University of Keele, Staffordshire, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Postgraduate Medicine, University of Keele, Staffordshire, U.K","institution_ids":["https://openalex.org/I56007636"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111969055"],"corresponding_institution_ids":["https://openalex.org/I56007636"],"apc_list":{"value":5660,"currency":"USD","value_usd":5660},"apc_paid":null,"fwci":0.6913,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.59047619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"36","issue":"1","first_page":"105","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.46239998936653137,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.25949999690055847,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.04190000146627426,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallstones","display_name":"gallstones","score":0.8349999785423279},{"id":"https://openalex.org/keywords/stone-formation","display_name":"stone formation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bilirubin","display_name":"bilirubin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytochrome-p450-monooxygenases","display_name":"cytochrome P450 monooxygenase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/heme-oxygenase","display_name":"heme oxygenase","score":0.984000027179718},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6949999928474426},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lithogenic-diet","display_name":"lithogenic diet","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2779388726","wikidata":"https://www.wikidata.org/wiki/Q272714","display_name":"Gallstones","level":2,"score":0.7519036531448364},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5805543065071106},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.46385571360588074},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.449144184589386},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4391299784183502},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4245035648345947},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.41922298073768616},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.413043349981308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3884723484516144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3877716064453125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38670918345451355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36418092250823975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3494201898574829},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3196095824241638}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003677","descriptor_name":"Deficiency Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007855","descriptor_name":"Lead Poisoning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0163-7258(88)90113-1","doi":"https://doi.org/10.1016/0163-7258(88)90113-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0163-7258(88)90113-1","pdf_url":null,"source":{"id":"https://openalex.org/S83493678","display_name":"Pharmacology & Therapeutics","issn_l":"0163-7258","issn":["0163-7258","1879-016X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:3277207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3277207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":151,"referenced_works":["https://openalex.org/W60886506","https://openalex.org/W114438298","https://openalex.org/W176717410","https://openalex.org/W181444798","https://openalex.org/W187714522","https://openalex.org/W324004358","https://openalex.org/W1497544956","https://openalex.org/W1530163795","https://openalex.org/W1556637879","https://openalex.org/W1575402562","https://openalex.org/W1606363918","https://openalex.org/W1699496274","https://openalex.org/W1878273062","https://openalex.org/W1893214027","https://openalex.org/W1963934879","https://openalex.org/W1965763721","https://openalex.org/W1970540527","https://openalex.org/W1972869620","https://openalex.org/W1972872754","https://openalex.org/W1975183470","https://openalex.org/W1977430125","https://openalex.org/W1977593695","https://openalex.org/W1979947322","https://openalex.org/W1981494789","https://openalex.org/W1985843448","https://openalex.org/W1985904589","https://openalex.org/W1988859967","https://openalex.org/W1989706954","https://openalex.org/W1992024164","https://openalex.org/W1996151392","https://openalex.org/W1997241639","https://openalex.org/W1999558767","https://openalex.org/W1999845724","https://openalex.org/W2002387779","https://openalex.org/W2003181425","https://openalex.org/W2003410018","https://openalex.org/W2008493621","https://openalex.org/W2009369301","https://openalex.org/W2010669389","https://openalex.org/W2012110786","https://openalex.org/W2012145030","https://openalex.org/W2015212155","https://openalex.org/W2016053698","https://openalex.org/W2016638329","https://openalex.org/W2018723869","https://openalex.org/W2020093167","https://openalex.org/W2021951883","https://openalex.org/W2023087657","https://openalex.org/W2023437376","https://openalex.org/W2023773946","https://openalex.org/W2024836835","https://openalex.org/W2026452699","https://openalex.org/W2027913934","https://openalex.org/W2028718177","https://openalex.org/W2028850868","https://openalex.org/W2033307496","https://openalex.org/W2034284632","https://openalex.org/W2034655909","https://openalex.org/W2035109495","https://openalex.org/W2036181145","https://openalex.org/W2041146258","https://openalex.org/W2041690820","https://openalex.org/W2042992343","https://openalex.org/W2045713901","https://openalex.org/W2047876579","https://openalex.org/W2049080092","https://openalex.org/W2054502000","https://openalex.org/W2056796375","https://openalex.org/W2057517957","https://openalex.org/W2058116596","https://openalex.org/W2059041609","https://openalex.org/W2061521258","https://openalex.org/W2066187891","https://openalex.org/W2066550908","https://openalex.org/W2066616691","https://openalex.org/W2067575222","https://openalex.org/W2073690806","https://openalex.org/W2078112792","https://openalex.org/W2079525977","https://openalex.org/W2080617384","https://openalex.org/W2082425802","https://openalex.org/W2082907668","https://openalex.org/W2084686194","https://openalex.org/W2092829687","https://openalex.org/W2094616547","https://openalex.org/W2096957843","https://openalex.org/W2103780900","https://openalex.org/W2106011317","https://openalex.org/W2128818892","https://openalex.org/W2137187169","https://openalex.org/W2144831605","https://openalex.org/W2152782390","https://openalex.org/W2153059088","https://openalex.org/W2164126025","https://openalex.org/W2213501008","https://openalex.org/W2226887088","https://openalex.org/W2236580798","https://openalex.org/W2287057939","https://openalex.org/W2292599282","https://openalex.org/W2297856617","https://openalex.org/W2315509859","https://openalex.org/W2315847782","https://openalex.org/W2323333260","https://openalex.org/W2326696623","https://openalex.org/W2330239169","https://openalex.org/W2335954545","https://openalex.org/W2336990701","https://openalex.org/W2337323504","https://openalex.org/W2338074007","https://openalex.org/W2338803732","https://openalex.org/W2340003488","https://openalex.org/W2395018419","https://openalex.org/W2396992818","https://openalex.org/W2397187277","https://openalex.org/W2397837605","https://openalex.org/W2399336238","https://openalex.org/W2400105348","https://openalex.org/W2401549588","https://openalex.org/W2402551620","https://openalex.org/W2403471401","https://openalex.org/W2403993806","https://openalex.org/W2406359580","https://openalex.org/W2408575099","https://openalex.org/W2409439477","https://openalex.org/W2409637718","https://openalex.org/W2409947791","https://openalex.org/W2410239286","https://openalex.org/W2410785625","https://openalex.org/W2411289595","https://openalex.org/W2411976206","https://openalex.org/W2412013807","https://openalex.org/W2412916388","https://openalex.org/W2413214088","https://openalex.org/W2413411183","https://openalex.org/W2413790362","https://openalex.org/W2414713631","https://openalex.org/W2415582185","https://openalex.org/W2415997764","https://openalex.org/W2418632154","https://openalex.org/W2418690552","https://openalex.org/W2418776695","https://openalex.org/W2419040271","https://openalex.org/W2428713294","https://openalex.org/W2460638277","https://openalex.org/W2461565216","https://openalex.org/W2472791101","https://openalex.org/W2474479599","https://openalex.org/W2796338337","https://openalex.org/W4234514850","https://openalex.org/W4238105857","https://openalex.org/W6639251337"],"related_works":["https://openalex.org/W2047040525","https://openalex.org/W4392536194","https://openalex.org/W2909143368","https://openalex.org/W2735676271","https://openalex.org/W2092601009","https://openalex.org/W2147976155","https://openalex.org/W1952847230","https://openalex.org/W4415822463","https://openalex.org/W2049573929","https://openalex.org/W2110713594"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}