{"id":"https://openalex.org/W2013559751","doi":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","title":"Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts","display_name":"Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2013559751","doi":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","mag":"2013559751","pmid":"https://pubmed.ncbi.nlm.nih.gov/11169735"},"language":"en","primary_location":{"id":"doi:10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","doi":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069638291","display_name":"Chandra M. Tummalapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra M. Tummalapalli","raw_affiliation_strings":["Department of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113469687","display_name":"Bobby J. Heath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bobby J. Heath","raw_affiliation_strings":["Cardiothoraciac Surgery, The University of Mississippi Medical Center, Jackson, Mississippi 39216"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiothoraciac Surgery, The University of Mississippi Medical Center, Jackson, Mississippi 39216","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003454740","display_name":"Suresh Chand Tyagi","orcid":"https://orcid.org/0000-0002-2457-5576","observed_orcids":["https://orcid.org/0000-0002-2457-5576"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suresh C. Tyagi","raw_affiliation_strings":["Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, Mississippi 39216","University of Mississippi Medical Center, Department of Physiology and Biophysics, 2500 North State Street, Jackson, MS 39216\u20104505"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, Mississippi 39216","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"University of Mississippi Medical Center, Department of Physiology and Biophysics, 2500 North State Street, Jackson, MS 39216\u20104505","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003454740"],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":3.0158,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.91791286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"80","issue":"4","first_page":"512","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.07000000029802322,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-inhibitor-of-metalloproteinase-4","display_name":"tissue inhibitor of metalloproteinase-4","score":0.9670000076293945},{"id":"https://openalex.org/keywords/timp-4","display_name":"TIMP-4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.9929999709129333},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.878000020980835},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.5820000171661377},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/collagenase-inhibition","display_name":"collagenase inhibition","score":0.7059999704360962},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6399999856948853},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7531485557556152},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.6907630562782288},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6797552704811096},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.5989558696746826},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5678041577339172},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5234536528587341},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4878237545490265},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.4872792959213257},{"id":"https://openalex.org/C155878803","wikidata":"https://www.wikidata.org/wiki/Q5205755","display_name":"DNA laddering","level":5,"score":0.476071298122406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42097729444503784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39447566866874695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16180816292762756},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1547223925590515},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.14264065027236938},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11189019680023193},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.06447044014930725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097792","descriptor_name":"Tissue Inhibitor of Metalloproteinase-4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009202","descriptor_name":"Cardiomyopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011120","descriptor_name":"Polyomavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","doi":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4644(20010315)80:4<512::aid-jcb1005>3.0.co;2-n","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:11169735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11169735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6129585621","display_name":"Cardiovascular Dynamics & Their Control","funder_award_id":"P01HL051971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G64215054","display_name":"REGULATORS OF NEUTROPHIL PROTEASES","funder_award_id":"R29GM048595","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W163741303","https://openalex.org/W195179619","https://openalex.org/W325551238","https://openalex.org/W1587660636","https://openalex.org/W1969958827","https://openalex.org/W1974379113","https://openalex.org/W1985392442","https://openalex.org/W1995034367","https://openalex.org/W2000125965","https://openalex.org/W2004091067","https://openalex.org/W2004383233","https://openalex.org/W2013044761","https://openalex.org/W2015985703","https://openalex.org/W2019256192","https://openalex.org/W2038135323","https://openalex.org/W2051991758","https://openalex.org/W2052860570","https://openalex.org/W2060848035","https://openalex.org/W2065447875","https://openalex.org/W2078466548","https://openalex.org/W2081722220","https://openalex.org/W2084162464","https://openalex.org/W2100837269","https://openalex.org/W2109658199","https://openalex.org/W2119050264","https://openalex.org/W2124559417","https://openalex.org/W2165659940","https://openalex.org/W2183821776","https://openalex.org/W2408236646","https://openalex.org/W4250908540"],"related_works":["https://openalex.org/W2139068414","https://openalex.org/W1976715667","https://openalex.org/W2076023054","https://openalex.org/W2086368972","https://openalex.org/W6903325560","https://openalex.org/W4246918852","https://openalex.org/W2067423036","https://openalex.org/W2004656949","https://openalex.org/W2124693576","https://openalex.org/W2017049923"],"abstract_inverted_index":{"Tumor":[0],"cells":[1,179,199,210],"become":[2],"malignant,":[3],"in":[4,39,56,109,160,200,231,240,276],"part,":[5],"because":[6],"of":[7,10,16,19,92,107,132,147,158,205,209,249,274],"their":[8],"activation":[9],"matrix":[11,260],"metalloproteinases":[12,20],"(MMPs)":[13],"and":[14,34,79,99,111,125,142,181,195,203,213,228,254,265],"inactivation":[15],"tissue":[17,51,66],"inhibitor":[18],"(TIMPs).":[21],"Myocardial":[22],"tumors":[23],"are":[24,36,280],"rarely":[25],"malignant.":[26],"This":[27,267],"raises":[28],"the":[29,32,40,57,201,242],"possibility":[30],"that":[31,49,174,221],"MMPs":[33],"TIMPs":[35],"differentially":[37],"regulated":[38],"heart":[41,87],"compared":[42,114],"to":[43,115,257,282],"other":[44,277],"tissues.":[45],"Therefore,":[46],"we":[47,63,191],"hypothesized":[48],"a":[50,237,270],"specific":[52],"tumor":[53],"suppressor":[54],"exists":[55],"heart.":[58,117],"To":[59,185],"test":[60,186],"this":[61],"hypothesis":[62],"prepared":[64],"cardiac":[65,161,177,193,225,263],"extracts":[67],"from":[68],"normal":[69,116,194,224,243],"(n":[70],"=":[71,77,84],"4),":[72],"ischemic":[73],"cardiomypathic":[74],"(ICM)":[75],"[n":[76,83],"5],":[78],"dilated":[80],"cardiomyopathic":[81],"(DCM)":[82],"8]":[85],"human":[86],"end-stage":[88],"explants.":[89],"The":[90,102,145,156,171,207,218,246],"level":[91],"cardiospecific":[93],"TIMP-4":[94,108,118,148,159,175,188,222,235,250,275],"was":[95,119,135,151,165,216],"determined":[96,136],"by":[97,121,153],"SDS-PAGE":[98],"Western-blot":[100],"analysis.":[101,170],"results":[103,172,219],"suggested":[104,173,220],"reduced":[105,247],"levels":[106,248],"ICM":[110],"DCM":[112],"as":[113,140],"purified":[120],"reverse":[122,154],"phase":[123],"HPLC":[124],"gelatin-sepharose":[126],"affinity":[127],"chromatography.":[128],"Collagenase":[129],"inhibitory":[130],"activity":[131,146],"chromatographic":[133],"peaks":[134],"using":[137,167],"fluorescein-conjugated":[138],"collagen":[139,182],"substrate":[141],"fluorescence":[143],"spectroscopy.":[144],"(27":[149],"kDa)":[150],"characterized":[152],"zymography.":[155],"role":[157,239,273],"fibroblast":[162,178,198,226],"cell":[163,244],"migration":[164,180],"examined":[166],"Boyden":[168],"chamber":[169],"inhibited":[176],"gel":[183],"invasion.":[184],"whether":[187],"induces":[189],"apoptosis,":[190],"cultured":[192],"polyomavirus":[196],"transformed":[197,232],"presence":[202],"absence":[204],"TIMP-4.":[206],"number":[208],"were":[211],"measured":[212],"DNA":[214],"laddering":[215],"determined.":[217],"controlled":[223],"transformation":[227,253],"induced":[229],"apoptosis":[230],"cells.":[233],"Cardiospecific":[234],"plays":[236],"significant":[238],"regulating":[241],"phenotype.":[245],"elicit":[251],"cellular":[252],"may":[255],"lead":[256],"adverse":[258],"extracellular":[259],"degradation":[261],"(remodeling),":[262],"hypertrophy":[264],"failure.":[266],"study":[268],"suggests":[269],"possible":[271],"protective":[272],"organs":[278],"which":[279],"susceptible":[281],"malignancy.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
