{"id":"https://openalex.org/W2013539337","doi":"https://doi.org/10.1007/bf01070828","title":"Lower esophageal sphincter responses to enteric hormones in two patients with Zollinger-Ellison syndrome","display_name":"Lower esophageal sphincter responses to enteric hormones in two patients with Zollinger-Ellison syndrome","publication_year":1975,"publication_date":"1975-08-01","ids":{"openalex":"https://openalex.org/W2013539337","doi":"https://doi.org/10.1007/bf01070828","mag":"2013539337","pmid":"https://pubmed.ncbi.nlm.nih.gov/1155411"},"language":"en","primary_location":{"id":"doi:10.1007/bf01070828","doi":"https://doi.org/10.1007/bf01070828","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01070828","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Digestive Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112020557","display_name":"Wallace C. Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. C. Wu","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109320234","display_name":"WJ Hogan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. J. Hogan","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","Mayo Clinic, Rochester, Minnesota","Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016765829","display_name":"George E. Whalen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. E. Whalen","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","Mayo Clinic, Rochester, Minnesota","Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039757242","display_name":"Samuel E. Hoke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. E. Hoke","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","Mayo Clinic, Rochester, Minnesota","Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109087336","display_name":"V. L. W. Go","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. L. W. Go","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","Mayo Clinic, Rochester, Minnesota","Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034090312","display_name":"R K Kalkhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210101863","display_name":"Milwaukee VA Medical Center","ror":"https://ror.org/0176arq92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101863","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. K. Kalkhoff","raw_affiliation_strings":["Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","Mayo Clinic, Rochester, Minnesota","Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Veterans Administration Center, Wood (Milwaukee), Wisconsin","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101863"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Milwaukee Country General Hospital, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.1735,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79609967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"8","first_page":"716","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.23399999737739563,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lower-esophageal-sphincter-tone","display_name":"lower esophageal sphincter tone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/zollinger-ellison-syndrome","display_name":"Zollinger-Ellison syndrome","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":0.9070000052452087},{"id":"https://openalex.org/keywords/secretin","display_name":"secretin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastrin","display_name":"gastrin","score":0.921999990940094},{"id":"https://openalex.org/keywords/hypergastrinemia","display_name":"hypergastrinemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/esophageal-motility","display_name":"esophageal motility","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2777351272","wikidata":"https://www.wikidata.org/wiki/Q218712","display_name":"Zollinger-Ellison syndrome","level":2,"score":0.876422643661499},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.673004686832428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.652836263179779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6005034446716309},{"id":"https://openalex.org/C2781283050","wikidata":"https://www.wikidata.org/wiki/Q786852","display_name":"Gastrinoma","level":4,"score":0.5648285746574402},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5418596267700195},{"id":"https://openalex.org/C3018799001","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophageal sphincter","level":4,"score":0.48215004801750183},{"id":"https://openalex.org/C2777951760","wikidata":"https://www.wikidata.org/wiki/Q5526842","display_name":"Gastrointestinal hormone","level":4,"score":0.415643572807312},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3405473232269287},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.2945612668991089},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.18493404984474182},{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.09777310490608215},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.06551405787467957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004943","descriptor_name":"Esophagogastric Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005768","descriptor_name":"Gastrointestinal Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008365","descriptor_name":"Manometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010418","descriptor_name":"Pentagastrin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010418","descriptor_name":"Pentagastrin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012633","descriptor_name":"Secretin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012633","descriptor_name":"Secretin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015043","descriptor_name":"Zollinger-Ellison Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015043","descriptor_name":"Zollinger-Ellison Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01070828","doi":"https://doi.org/10.1007/bf01070828","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01070828","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Digestive Diseases","raw_type":"journal-article"},{"id":"pmid:1155411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1155411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of digestive diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1970499927","https://openalex.org/W1991116148","https://openalex.org/W1996620350","https://openalex.org/W1998152866","https://openalex.org/W2020412988","https://openalex.org/W2030528747","https://openalex.org/W2037572243","https://openalex.org/W2050946651","https://openalex.org/W2081055842","https://openalex.org/W2094369856","https://openalex.org/W2417207766","https://openalex.org/W2418398474","https://openalex.org/W2428029791","https://openalex.org/W2437433694","https://openalex.org/W2444169861","https://openalex.org/W4298409403","https://openalex.org/W4299935407"],"related_works":["https://openalex.org/W1437730863","https://openalex.org/W2134885742","https://openalex.org/W2444169861","https://openalex.org/W2408807231","https://openalex.org/W2038616009","https://openalex.org/W2415256506","https://openalex.org/W1997525379","https://openalex.org/W1964783715","https://openalex.org/W2340846964","https://openalex.org/W4299935407"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}