{"id":"https://openalex.org/W2013534590","doi":"https://doi.org/10.1246/cl.1993.741","title":"Optical Resolution of a d-Biotin Chiral Intermediate by Use of Lipoprotein Lipase","display_name":"Optical Resolution of a d-Biotin Chiral Intermediate by Use of Lipoprotein Lipase","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2013534590","doi":"https://doi.org/10.1246/cl.1993.741","mag":"2013534590"},"language":"en","primary_location":{"id":"doi:10.1246/cl.1993.741","doi":"https://doi.org/10.1246/cl.1993.741","is_oa":false,"landing_page_url":"https://doi.org/10.1246/cl.1993.741","pdf_url":null,"source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111206011","display_name":"Shinji Tokuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Tokuyama","raw_affiliation_strings":["Technology Development Laboratories, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Laboratories, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110091620","display_name":"Toru Yamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Yamano","raw_affiliation_strings":["Technology Development Laboratories, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Laboratories, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354863","display_name":"Isao Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Aoki","raw_affiliation_strings":["Technology Development Laboratories, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Laboratories, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056852240","display_name":"Kunio Takanohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Takanohashi","raw_affiliation_strings":["Technology Development Laboratories, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Laboratories, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045137047","display_name":"Kazuo Nakahama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Nakahama","raw_affiliation_strings":["Technology Development Laboratories, Takeda Chemical Industries, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Development Laboratories, Takeda Chemical Industries, Ltd","institution_ids":["https://openalex.org/I44892455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44892455"],"apc_list":{"value":150000,"currency":"JPY","value_usd":1003},"apc_paid":null,"fwci":0.1089,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.28790168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"22","issue":"4","first_page":"741","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-resolution","display_name":"optical resolution","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.8450000286102295},{"id":"https://openalex.org/keywords/chiral-auxiliaries","display_name":"chiral auxiliaries","score":0.5559999942779541},{"id":"https://openalex.org/keywords/enantioselective-acylation","display_name":"enantioselective acylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/enantiomeric-excess","display_name":"enantiomeric excess","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9512777328491211},{"id":"https://openalex.org/C193557335","wikidata":"https://www.wikidata.org/wiki/Q61424","display_name":"Acylation","level":3,"score":0.8319776654243469},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.7803109884262085},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.6361860036849976},{"id":"https://openalex.org/C2778142098","wikidata":"https://www.wikidata.org/wiki/Q15779","display_name":"Toluene","level":2,"score":0.5666801929473877},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.545864999294281},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5201833248138428},{"id":"https://openalex.org/C2780786110","wikidata":"https://www.wikidata.org/wiki/Q7839871","display_name":"Triacylglycerol lipase","level":4,"score":0.4755803644657135},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.43016815185546875},{"id":"https://openalex.org/C3019471444","wikidata":"https://www.wikidata.org/wiki/Q530648","display_name":"Optically active","level":2,"score":0.4256175756454468},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38189491629600525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2668919265270233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.229802668094635},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.22458598017692566},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1246/cl.1993.741","doi":"https://doi.org/10.1246/cl.1993.741","is_oa":false,"landing_page_url":"https://doi.org/10.1246/cl.1993.741","pdf_url":null,"source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1488619234","https://openalex.org/W1974807891","https://openalex.org/W1978754543","https://openalex.org/W1982392910","https://openalex.org/W1997756506","https://openalex.org/W2019586138","https://openalex.org/W2030795605","https://openalex.org/W2032737762","https://openalex.org/W2036083800","https://openalex.org/W2085451705","https://openalex.org/W2085708781","https://openalex.org/W2086957527","https://openalex.org/W2403383100","https://openalex.org/W2949447634"],"related_works":["https://openalex.org/W2949223122","https://openalex.org/W2061948116","https://openalex.org/W2103387158","https://openalex.org/W1986823235","https://openalex.org/W2076907709","https://openalex.org/W2009015225","https://openalex.org/W2069241745","https://openalex.org/W2075296515","https://openalex.org/W17958573","https://openalex.org/W1979194554"],"abstract_inverted_index":{"Abstract":[0],"An":[1],"efficient":[2],"optical":[3,41],"resolution":[4],"of":[5,46],"(\u00b1)-(3a\u03b1,4\u03b1,6a\u03b1)-1,3-dibenzyl-3a,4,6,6a-tetrahydro-4-hydroxy-1H-thieno[3,4-d]imidazol-2(3H)-one":[6],"[(RS)-1]":[7],"was":[8,35],"accomplished":[9],"by":[10],"acylation":[11],"with":[12],"lipoprotein":[13],"lipase":[14,22],"from":[15],"Pseudomonas":[16],"aeruginosa":[17],"TE3285":[18],"in":[19,37],"toluene.":[20],"The":[21],"acylated":[23],"(R)-1":[24],"enantioselectively,":[25],"and":[26,40,51],"unreacted":[27],"(S)-1,":[28],"which":[29],"is":[30],"a":[31],"chiral":[32],"d-biotin":[33],"intermediate,":[34],"isolated":[36],"excellent":[38],"chemical":[39],"yields":[42],"(>99%":[43],"e.e.).":[44],"Effects":[45],"acylating":[47],"agents,":[48],"water":[49],"content":[50],"molecular":[52],"sieves":[53],"were":[54],"also":[55],"investigated.":[56]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}