{"id":"https://openalex.org/W2013532800","doi":"https://doi.org/10.1371/journal.pone.0054325","title":"Evaluation of Physical and Functional Protein-Protein Interaction Prediction Methods for Detecting Biological Pathways","display_name":"Evaluation of Physical and Functional Protein-Protein Interaction Prediction Methods for Detecting Biological Pathways","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2013532800","doi":"https://doi.org/10.1371/journal.pone.0054325","mag":"2013532800","pmid":"https://pubmed.ncbi.nlm.nih.gov/23349851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3547882"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0054325","doi":"https://doi.org/10.1371/journal.pone.0054325","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0054325","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054325&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054325&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015422165","display_name":"Vijaykumar Yogesh Muley","orcid":"https://orcid.org/0000-0001-5329-600X","observed_orcids":["https://orcid.org/0000-0001-5329-600X"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijaykumar Yogesh Muley","raw_affiliation_strings":["Computational and Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015027837","display_name":"Akash Ranjan","orcid":"https://orcid.org/0000-0002-4582-1553","observed_orcids":["https://orcid.org/0000-0002-4582-1553"]},"institutions":[{"id":"https://openalex.org/I78270026","display_name":"Centre for DNA Fingerprinting and Diagnostics","ror":"https://ror.org/04psbxy09","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I78270026"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Akash Ranjan","raw_affiliation_strings":["Computational and Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational and Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India","institution_ids":["https://openalex.org/I78270026"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015027837"],"corresponding_institution_ids":["https://openalex.org/I78270026"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5041,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.56429141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"e54325","last_page":"e54325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction-prediction","display_name":"protein-protein interaction prediction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9369999766349792},{"id":"https://openalex.org/keywords/kegg-pathways","display_name":"KEGG pathways","score":0.7590000033378601},{"id":"https://openalex.org/keywords/phylogenetic-profiling","display_name":"phylogenetic profiling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gene-neighborhood","display_name":"gene neighborhood","score":0.9340000152587891},{"id":"https://openalex.org/keywords/orthologous-gene-clusters","display_name":"orthologous gene clusters","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gene-expression-similarity","display_name":"gene expression similarity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.7073737382888794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6663074493408203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6594749689102173},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6202049851417542},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5394488573074341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.529342532157898},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5130785703659058},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.49421122670173645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40095436573028564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17715972661972046},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.16616106033325195}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0054325","doi":"https://doi.org/10.1371/journal.pone.0054325","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0054325","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054325&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2552723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3547882","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23349851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23349851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Evaluation Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:3547882","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3547882/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.1408","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.1408","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/2d/pone.0054325.PMC3547882.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0054325","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a3b9bce8f2c1437fa8795c4a7c45e84b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a3b9bce8f2c1437fa8795c4a7c45e84b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 1, p e54325 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/114452","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evaluation_of_Physical_and_Functional_Protein_Protein_Interaction_Prediction_Methods_for_Detecting_Biological_Pathways__/114452","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0054325","doi":"https://doi.org/10.1371/journal.pone.0054325","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0054325","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054325&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013532800.pdf","grobid_xml":"https://content.openalex.org/works/W2013532800.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1515226261","https://openalex.org/W1533936090","https://openalex.org/W1588911128","https://openalex.org/W1966378982","https://openalex.org/W1968698890","https://openalex.org/W1972314084","https://openalex.org/W1974232498","https://openalex.org/W1980578041","https://openalex.org/W1990453950","https://openalex.org/W1991071802","https://openalex.org/W1995117714","https://openalex.org/W2009966494","https://openalex.org/W2010577059","https://openalex.org/W2018756605","https://openalex.org/W2025853251","https://openalex.org/W2036847531","https://openalex.org/W2048639844","https://openalex.org/W2057885377","https://openalex.org/W2061439657","https://openalex.org/W2073610238","https://openalex.org/W2074009961","https://openalex.org/W2084902262","https://openalex.org/W2101058428","https://openalex.org/W2101783948","https://openalex.org/W2106945333","https://openalex.org/W2107424557","https://openalex.org/W2107717979","https://openalex.org/W2107903949","https://openalex.org/W2109715166","https://openalex.org/W2113654464","https://openalex.org/W2118753015","https://openalex.org/W2123836768","https://openalex.org/W2124160106","https://openalex.org/W2131531207","https://openalex.org/W2133138357","https://openalex.org/W2137012036","https://openalex.org/W2142237411","https://openalex.org/W2145126338","https://openalex.org/W2149310258","https://openalex.org/W2152360905","https://openalex.org/W2152568394","https://openalex.org/W2158714788","https://openalex.org/W2166779336","https://openalex.org/W2167774246","https://openalex.org/W2169382386","https://openalex.org/W2170011129","https://openalex.org/W2171512516","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W2074009961","https://openalex.org/W2123836768","https://openalex.org/W2155972151","https://openalex.org/W2039665506","https://openalex.org/W7099989271","https://openalex.org/W1513999258","https://openalex.org/W1506419162","https://openalex.org/W7095084352","https://openalex.org/W2109715166","https://openalex.org/W2161712694"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cellular":[1],"activities":[2],"are":[3,107,224,231],"governed":[4],"by":[5,234],"the":[6,9,21,54,68,72,78,85,117,132,179,197,203,220,258,268,286],"physical":[7],"and":[8,26,124,171,185],"functional":[10,101,161],"interactions":[11,35,48,76,138,194],"among":[12,77,196],"several":[13],"proteins":[14,164],"involved":[15,165,195],"in":[16,45,53,95,116,166,219],"various":[17,37],"biological":[18,64,80,89],"pathways.":[19],"With":[20],"availability":[22],"of":[23,42,70,75,87,91,113,134,154,163,222,237,261],"sequenced":[24],"genomes":[25],"high-throughput":[27],"experimental":[28],"data":[29],"one":[30,274],"can":[31],"identify":[32],"genome-wide":[33],"protein-protein":[34,100,215],"using":[36,98,235],"computational":[38],"techniques.":[39],"Comparative":[40],"assessments":[41],"these":[43,155],"techniques":[44],"predicting":[46],"protein":[47,137,251],"have":[49,159,254],"been":[50],"frequently":[51],"reported":[52],"literature":[55],"but":[56],"not":[57,276],"their":[58],"ability":[59],"to":[60,140,246],"elucidate":[61],"a":[62,121,142,262],"particular":[63,263],"pathway.":[65],"METHODS:":[66],"Towards":[67],"goal":[69],"understanding":[71],"prediction":[73,103,133,264],"capabilities":[74],"specific":[79,279],"pathway":[81,136,250,269],"proteins,":[82],"we":[83],"report":[84],"analyses":[86],"14":[88],"pathways":[90,175,230],"Escherichia":[92],"coli":[93],"catalogued":[94],"KEGG":[96],"database":[97],"five":[99],"linkage":[102],"methods.":[104],"These":[105,157],"methods":[106,147,158],"phylogenetic":[108],"profiling,":[109],"gene":[110,119,281],"neighborhood,":[111],"co-presence":[112],"orthologous":[114,238],"genes":[115,239],"same":[118],"clusters,":[120],"mirrortree":[122],"variant,":[123],"expression":[125,282],"similarity.":[126],"CONCLUSIONS:":[127],"Our":[128],"results":[129],"reveal":[130],"that":[131,217,257],"metabolic":[135],"continues":[139],"be":[141],"challenging":[143],"task":[144],"for":[145,193],"all":[146],"which":[148],"possibly":[149],"reflect":[150],"flexible/independent":[151],"evolutionary":[152],"histories":[153],"proteins.":[156,201],"predicted":[160,225,233],"associations":[162],"amino":[167],"acids,":[168],"nucleotide,":[169],"glycans":[170],"vitamins":[172],"&":[173],"co-factors":[174],"slightly":[176],"better":[177],"than":[178],"random":[180],"performance":[181],"on":[182,267,278],"carbohydrate,":[183],"lipid":[184],"energy":[186],"metabolism.":[187],"We":[188,253],"also":[189,255],"make":[190],"similar":[191],"observations":[192],"environmental":[198],"information":[199,206],"processing":[200,207],"On":[202],"contrary,":[204],"genetic":[205],"or":[208],"specialized":[209],"processes":[210],"such":[211],"as":[212],"motility":[213],"related":[214],"linkages":[216],"occur":[218],"subset":[221],"organisms":[223],"with":[226],"comparable":[227],"accuracy.":[228],"Metabolic":[229],"best":[232,287],"neighborhood":[236],"whereas":[240],"phyletic":[241],"pattern":[242],"is":[243,275,285],"good":[244],"enough":[245],"reconstruct":[247],"central":[248],"dogma":[249],"interactions.":[252],"shown":[256],"effective":[259],"use":[260],"method":[265,284],"depends":[266],"under":[270],"investigation.":[271],"In":[272],"case":[273],"focused":[277],"pathway,":[280],"similarity":[283],"option.":[288]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}