{"id":"https://openalex.org/W2013530163","doi":"https://doi.org/10.1038/sj.jim.2900699","title":"Expression of the fusion protein recombinant human granulocyte-macrophage colony stimulating factor and leukemia inhibitory factor in a baculovirus vector system","display_name":"Expression of the fusion protein recombinant human granulocyte-macrophage colony stimulating factor and leukemia inhibitory factor in a baculovirus vector system","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2013530163","doi":"https://doi.org/10.1038/sj.jim.2900699","mag":"2013530163","pmid":"https://pubmed.ncbi.nlm.nih.gov/10510487"},"language":"en","primary_location":{"id":"doi:10.1038/sj.jim.2900699","doi":"https://doi.org/10.1038/sj.jim.2900699","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.jim.2900699","pdf_url":null,"source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111805351","display_name":"XW Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X-W Zhang","raw_affiliation_strings":["Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People's Republic of China","grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"X-Y Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X-Y Zeng","raw_affiliation_strings":["grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031315305","display_name":"Tao Sun","orcid":"https://orcid.org/0000-0002-7575-3483","observed_orcids":["https://orcid.org/0000-0002-7575-3483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sun","raw_affiliation_strings":["grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032998307","display_name":"X Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Liu","raw_affiliation_strings":["grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109121479","display_name":"D-X Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D-X Gu","raw_affiliation_strings":["grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.12981.33 000000012360039X Food Engineering Research Center of State Education Department, Zhongshan University, Guangzhou 510275, People\u2019s Republic of China      CN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2921,"currency":"USD","value_usd":2921},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"2","first_page":"103","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9660000205039978},{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":1.0},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"fusion protein","score":0.9369999766349792},{"id":"https://openalex.org/keywords/baculovirus-expression-system","display_name":"baculovirus expression system","score":0.8790000081062317},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sf9-cells","display_name":"Sf9 cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/fall-armyworm","display_name":"Spodoptera frugiperda","score":0.9330000281333923},{"id":"https://openalex.org/keywords/insect-cell-expression-system","display_name":"insect cell expression","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C103878061","wikidata":"https://www.wikidata.org/wiki/Q28840674","display_name":"Sf9","level":5,"score":0.7531603574752808},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6919775009155273},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6886814832687378},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.6637321710586548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6124352812767029},{"id":"https://openalex.org/C27284151","wikidata":"https://www.wikidata.org/wiki/Q6534502","display_name":"Leukemia inhibitory factor","level":4,"score":0.6106006503105164},{"id":"https://openalex.org/C2780943621","wikidata":"https://www.wikidata.org/wiki/Q1313618","display_name":"Monocytic leukemia","level":3,"score":0.537916898727417},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4844801127910614},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4756811857223511},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.4658523499965668},{"id":"https://openalex.org/C2777773057","wikidata":"https://www.wikidata.org/wiki/Q2492887","display_name":"Spodoptera","level":4,"score":0.4518846273422241},{"id":"https://openalex.org/C2779341487","wikidata":"https://www.wikidata.org/wiki/Q1375305","display_name":"Trichoplusia","level":4,"score":0.44594258069992065},{"id":"https://openalex.org/C39060996","wikidata":"https://www.wikidata.org/wiki/Q7302706","display_name":"Recombinant virus","level":4,"score":0.4325541853904724},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.234115332365036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19215640425682068},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10249841213226318},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09403008222579956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08479729294776917},{"id":"https://openalex.org/C2778350275","wikidata":"https://www.wikidata.org/wiki/Q459180","display_name":"Noctuidae","level":3,"score":0.054183751344680786},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.jim.2900699","doi":"https://doi.org/10.1038/sj.jim.2900699","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.jim.2900699","pdf_url":null,"source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:10510487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10510487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of industrial microbiology & biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W205635173","https://openalex.org/W1484177930","https://openalex.org/W1597733532","https://openalex.org/W2040224276","https://openalex.org/W2043222621","https://openalex.org/W2065134530","https://openalex.org/W2083947036","https://openalex.org/W2138270253","https://openalex.org/W2266106978","https://openalex.org/W2314427160"],"related_works":["https://openalex.org/W2378719848","https://openalex.org/W2045341927","https://openalex.org/W2053414013","https://openalex.org/W2376390158","https://openalex.org/W2371176922","https://openalex.org/W2373344168","https://openalex.org/W2097901306","https://openalex.org/W6991129651","https://openalex.org/W280849720","https://openalex.org/W2356479527"],"abstract_inverted_index":{"A":[0],"fusion":[1,53,91,113,122],"gene":[2],"coding":[3],"human":[4,56],"granulocyte-macrophage":[5,57],"colony":[6,58],"stimulating":[7,59],"factor":[8,13,60,65],"(GM-CSF)":[9,61],"and":[10,29,43,62,105],"leukemia":[11,63],"inhibitory":[12,64],"(LIF)":[14,66],"cDNAs":[15],"was":[16],"inserted":[17],"into":[18],"the":[19,25,40,90,100,111,120],"transfer":[20],"vector":[21],"pSXIVVI+":[22],"X3":[23],"with":[24,39,73,124,134],"control":[26],"of":[27,79,82,89,103,110,128],"Syn":[28],"XIV":[30],"promoters.":[31],"The":[32,52],"Sf9":[33],"cells":[34,71,95],"(Spodoptera":[35],"frugiperda)":[36],"were":[37],"co-transfected":[38],"recombinant":[41,55,74],"plasmid":[42],"TnNPV":[44],"DNA":[45],"(Trichoplusia":[46],"ni":[47],"nuclear":[48],"polyhedrosis":[49],"virus":[50,75],"DNA).":[51],"protein":[54,92,114],"could":[67],"be":[68],"synthesized":[69],"in":[70,93,115],"infected":[72,94,116],"at":[76],"a":[77,125],"level":[78],"about":[80],"23%":[81],"their":[83],"total":[84],"cellular":[85],"protein.":[86],"Activity":[87],"analysis":[88,109],"revealed":[96],"that":[97,119],"it":[98],"exhibited":[99],"dual":[101],"activities":[102],"GM-CSF":[104],"LIF.":[106],"Western":[107],"blot":[108],"expressed":[112],"larvae":[117],"showed":[118],"virus-mediated":[121],"protein,":[123],"molecular":[126],"weight":[127],"approximately":[129],"35":[130],"kDa,":[131],"is":[132],"confirmed":[133],"immunoreactivity.":[135]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
