{"id":"https://openalex.org/W2013527047","doi":"https://doi.org/10.1177/0091270011414575","title":"Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption","display_name":"Meclizine Metabolism and Pharmacokinetics: Formulation on Its Absorption","publication_year":2011,"publication_date":"2011-09-09","ids":{"openalex":"https://openalex.org/W2013527047","doi":"https://doi.org/10.1177/0091270011414575","mag":"2013527047","pmid":"https://pubmed.ncbi.nlm.nih.gov/21903894"},"language":"en","primary_location":{"id":"doi:10.1177/0091270011414575","doi":"https://doi.org/10.1177/0091270011414575","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270011414575","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100437344","display_name":"Zhijun Kevin Wang","orcid":"https://orcid.org/0000-0001-8783-8946","observed_orcids":["https://orcid.org/0000-0001-8783-8946"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhijun Wang","raw_affiliation_strings":["Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, 309E, 2nd St, Pomona, CA 91766, USA","Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, 309E, 2nd St, Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]},{"raw_affiliation_string":"Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763128","display_name":"Benjamin Lee","orcid":"https://orcid.org/0000-0001-6826-7463","observed_orcids":["https://orcid.org/0000-0001-6826-7463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Lee","raw_affiliation_strings":["Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Pearce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Pearce","raw_affiliation_strings":["Department of Internal Medicine, Western University of Health Science, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Western University of Health Science, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077204577","display_name":"Shuai Qian","orcid":"https://orcid.org/0000-0003-1961-4128","observed_orcids":["https://orcid.org/0000-0003-1961-4128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuai Qian","raw_affiliation_strings":["Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100645706","display_name":"Yanfeng Wang","orcid":"https://orcid.org/0000-0002-3859-0937","observed_orcids":["https://orcid.org/0000-0002-3859-0937"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanfeng Wang","raw_affiliation_strings":["Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004136136","display_name":"Qizhi Zhang","orcid":"https://orcid.org/0000-0002-8544-609X","observed_orcids":["https://orcid.org/0000-0002-8544-609X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qizhi Zhang","raw_affiliation_strings":["Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong","Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Drug Enterprises Ltd, Shatin, Hong Kong","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059925734","display_name":"Moses S.S. Chow","orcid":"https://orcid.org/0000-0001-7794-6214","observed_orcids":["https://orcid.org/0000-0001-7794-6214"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Moses S. S. Chow","raw_affiliation_strings":["Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, Pomona, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Science, Pomona, California","institution_ids":["https://openalex.org/I93393672"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059925734"],"corresponding_institution_ids":["https://openalex.org/I93393672"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.3041,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.74613109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"52","issue":"9","first_page":"1343","last_page":"1349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meclizine","display_name":"meclizine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5910000205039978},{"id":"https://openalex.org/keywords/suspension-formulation","display_name":"suspension formulation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9240000247955322},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.9620000123977661},{"id":"https://openalex.org/keywords/motion-sickness","display_name":"motion sickness","score":0.8429999947547913},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8130000233650208},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7089999914169312},{"id":"https://openalex.org/keywords/onset-of-action","display_name":"onset of action","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8460599184036255},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6848365068435669},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.6744036674499512},{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.6416425704956055},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5707736611366272},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4616625905036926},{"id":"https://openalex.org/C46821324","wikidata":"https://www.wikidata.org/wiki/Q7094540","display_name":"Onset of action","level":2,"score":0.43978917598724365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4345815181732178},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.41229766607284546},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.29793015122413635},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.289470374584198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2594316899776459},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0769849419593811},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008468","descriptor_name":"Meclizine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008468","descriptor_name":"Meclizine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008468","descriptor_name":"Meclizine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0091270011414575","doi":"https://doi.org/10.1177/0091270011414575","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270011414575","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:21903894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21903894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W196795570","https://openalex.org/W1953670646","https://openalex.org/W1984131408","https://openalex.org/W1986260863","https://openalex.org/W2011944629","https://openalex.org/W2047705730","https://openalex.org/W2056263935","https://openalex.org/W2080358517","https://openalex.org/W2273032719","https://openalex.org/W2315833978","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1986260863","https://openalex.org/W2431886656","https://openalex.org/W2143798559","https://openalex.org/W152080286","https://openalex.org/W2079238640","https://openalex.org/W1977749675","https://openalex.org/W2058636852","https://openalex.org/W2138049592","https://openalex.org/W53490840","https://openalex.org/W2027818128"],"abstract_inverted_index":{"Meclizine,":[0],"an":[1,80],"antihistamine,":[2],"has":[3],"been":[4],"widely":[5],"used":[6,197],"for":[7,26,147,198],"prophylactic":[8],"treatment":[9,28],"and":[10,32,89,127,151],"management":[11,200],"of":[12,18,20,29,38,55,108,125,149,164,174,194,201],"motion":[13,30,202],"sickness.":[14,203],"However,":[15],"the":[16,27,44,53,56,61,98,102,116,136,144,158,165,175,180,199],"onset":[17,193],"action":[19,195],"meclizine":[21,39,63,177],"was":[22,41,72,93,140],"about":[23],"1":[24,69],"hour":[25],"sickness":[31],"vertigo.":[33],"A":[34],"new":[35,57,184],"suspension":[36],"formulation":[37,59,185],"(MOS)":[40],"developed":[42],"with":[43,168],"intention":[45],"to":[46,96,115,142,157,188],"achieve":[47],"a":[48,67,169,190],"rapid":[49],"effect.":[50],"To":[51],"investigate":[52],"pharmacokinetics":[54],"MOS":[58,109,181],"versus":[60],"marketed":[62],"oral":[64],"tablet":[65],"(MOT),":[66],"phase":[68],"pharmacokinetic":[70],"study":[71,84],"performed":[73,95],"in":[74,81,101,113,133],"20":[75],"healthy":[76],"volunteers.":[77],"In":[78,162],"addition,":[79],"vitro":[82],"metabolic":[83,99],"using":[85],"human":[86,103],"hepatic":[87],"microsome":[88],"recombinant":[90],"CYP":[91],"enzyme":[92,146],"also":[94],"determine":[97],"pathway":[100],"body.":[104],"The":[105,118],"plasma":[106,176],"concentration":[107,178],"appeared":[110],"more":[111],"rapidly":[112],"comparison":[114],"MOT.":[117],"geometric":[119],"mean":[120],"ratios":[121],"(90%":[122],"confidence":[123],"interval)":[124],"AUC(0-24)":[126],"AUC(0-\u221e)":[128],"indicated":[129],"no":[130],"significant":[131],"difference":[132],"bioavailability":[134,167],"between":[135],"2":[137],"formulations.":[138],"CYP2D6":[139],"found":[141],"be":[143],"dominant":[145],"metabolism":[148],"meclizine,":[150],"its":[152],"genetic":[153],"polymorphism":[154],"could":[155],"contribute":[156],"large":[159],"interindividual":[160],"variability.":[161],"view":[163],"similar":[166],"much":[170,191],"shorter":[171],"peak":[172],"time":[173],"from":[179],"formulation,":[182],"this":[183],"is":[186],"expected":[187],"produce":[189],"quicker":[192],"when":[196]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
