{"id":"https://openalex.org/W2013519952","doi":"https://doi.org/10.1179/1973947812y.0000000063","title":"In vitroactivity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics","display_name":"In vitroactivity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2013519952","doi":"https://doi.org/10.1179/1973947812y.0000000063","mag":"2013519952","pmid":"https://pubmed.ncbi.nlm.nih.gov/23433440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3558989"},"language":"en","primary_location":{"id":"doi:10.1179/1973947812y.0000000063","doi":"https://doi.org/10.1179/1973947812y.0000000063","is_oa":true,"landing_page_url":"https://doi.org/10.1179/1973947812y.0000000063","pdf_url":"https://www.tandfonline.com/doi/epdf/10.1179/1973947812Y.0000000063?needAccess=true&role=button","source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/epdf/10.1179/1973947812Y.0000000063?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045310388","display_name":"Nachum Kaplan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nachum Kaplan","raw_affiliation_strings":["Affinium Pharmaceuticals, Inc., Toronto, ON M5V 3K2, Canada. nkaplan@afnm.com","Affinium Pharmaceuticals, Inc., Toronto, ON M5V 3K2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affinium Pharmaceuticals, Inc., Toronto, ON M5V 3K2, Canada. nkaplan@afnm.com","institution_ids":[]},{"raw_affiliation_string":"Affinium Pharmaceuticals, Inc., Toronto, ON M5V 3K2, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109083161","display_name":"Donald E. Awrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Donald Awrey","raw_affiliation_strings":["Campbell Family Institute for Breast Cancer ResearchToronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campbell Family Institute for Breast Cancer ResearchToronto, ON, Canada","institution_ids":["https://openalex.org/I4405278476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006403866","display_name":"Elias Bardouniotis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elias Bardouniotis","raw_affiliation_strings":["Switzerland Trade and Investment Promotion, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Switzerland Trade and Investment Promotion, Toronto, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060697254","display_name":"Judd Berman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139400","display_name":"Dalton Pharma Services (Canada)","ror":"https://ror.org/04v0pva46","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210139400"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Judd Berman","raw_affiliation_strings":["Dalton Medicinal Chemistry Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalton Medicinal Chemistry Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210139400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030495283","display_name":"Jeremy A. Yethon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Yethon","raw_affiliation_strings":["Sanofi PasteurCambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi PasteurCambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020565888","display_name":"Henry W. Pauls","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405278476","display_name":"Campbell Family Institute for Breast Cancer Research","ror":"https://ror.org/003wr7003","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988","https://openalex.org/I4405278476"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Henry W Pauls","raw_affiliation_strings":["Campbell Family Institute for Breast Cancer ResearchToronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campbell Family Institute for Breast Cancer ResearchToronto, ON, Canada","institution_ids":["https://openalex.org/I4405278476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087580457","display_name":"Barry Hafkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry Hafkin","raw_affiliation_strings":["Affinium PharmaceuticalsInc., Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affinium PharmaceuticalsInc., Toronto, ON, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045310388"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0824,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94018103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"18","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fabi-inhibitors","display_name":"FabI inhibitors","score":0.9350000023841858},{"id":"https://openalex.org/keywords/fatty-acid-synthesis-inhibition","display_name":"fatty acid synthesis inhibition","score":0.8629999756813049},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.7990000247955322},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7490000128746033},{"id":"https://openalex.org/keywords/postantibiotic-effect","display_name":"post-antibiotic effect","score":0.9300000071525574},{"id":"https://openalex.org/keywords/gentamicin-synergy","display_name":"gentamicin synergy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antibiotic-interactions","display_name":"antibiotic interactions","score":0.6869999766349792},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.8450000286102295},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.7770000100135803},{"id":"https://openalex.org/keywords/staphylococcal-infections","display_name":"staphylococcal infections","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7051160335540771},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6938208937644958},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6828858852386475},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5199816823005676},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4808688759803772},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.46890345215797424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44247111678123474},{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.4408145546913147},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3737776279449463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3215634226799011},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.30699920654296875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1967250406742096},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.17403709888458252},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008712","descriptor_name":"Methicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011753","descriptor_name":"Pyrones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011753","descriptor_name":"Pyrones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1179/1973947812y.0000000063","doi":"https://doi.org/10.1179/1973947812y.0000000063","is_oa":true,"landing_page_url":"https://doi.org/10.1179/1973947812y.0000000063","pdf_url":"https://www.tandfonline.com/doi/epdf/10.1179/1973947812Y.0000000063?needAccess=true&role=button","source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2606779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3558989","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3558989","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3558989","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Chemother","raw_type":"Text"},{"id":"pmid:23433440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23433440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1179/1973947812y.0000000063","doi":"https://doi.org/10.1179/1973947812y.0000000063","is_oa":true,"landing_page_url":"https://doi.org/10.1179/1973947812y.0000000063","pdf_url":"https://www.tandfonline.com/doi/epdf/10.1179/1973947812Y.0000000063?needAccess=true&role=button","source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013519952.pdf","grobid_xml":"https://content.openalex.org/works/W2013519952.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1499823044","https://openalex.org/W1965838591","https://openalex.org/W1973979786","https://openalex.org/W1976239530","https://openalex.org/W2021756057","https://openalex.org/W2064746154","https://openalex.org/W2067677115","https://openalex.org/W2069782630","https://openalex.org/W2073728193","https://openalex.org/W2098544401","https://openalex.org/W2108525727","https://openalex.org/W2129436053","https://openalex.org/W2160244841","https://openalex.org/W2949449768"],"related_works":["https://openalex.org/W7098939483","https://openalex.org/W2072232626","https://openalex.org/W2064182499","https://openalex.org/W2098544401","https://openalex.org/W7098061200","https://openalex.org/W1965838591","https://openalex.org/W2311914439","https://openalex.org/W2165240086","https://openalex.org/W2008628182","https://openalex.org/W2124135279"],"abstract_inverted_index":{"AFN-1252":[0,17,82,93,118,151],"is":[1,84,123],"a":[2,95,113,153],"novel":[3],"inhibitor":[4],"of":[5,22,29,51,90,99,121,138,150],"FabI,":[6],"an":[7,59],"essential":[8],"enzyme":[9],"in":[10,14,39,62,87],"fatty":[11],"acid":[12],"biosynthesis":[13],"Staphylococcus":[15],"spp.":[16],"exhibits":[18,94],"typical":[19],"MIC(90)":[20],"values":[21],"\u22640\u00b7015":[23],"\u03bcg/ml":[24],"against":[25,102,140],"diverse":[26],"clinical":[27],"isolates":[28],"S.":[30,104,109],"aureus,":[31],"oral":[32],"absorption,":[33],"long":[34,74],"elimination":[35,75],"half-live":[36],"and":[37,55,67,107,142],"efficacy":[38],"animal":[40],"models.":[41],"We":[42],"now":[43],"report":[44],"high":[45],"binding":[46],"(\u223c95%)":[47],"to":[48],"serum":[49],"proteins":[50],"mouse,":[52],"rat,":[53],"dog":[54],"humans,":[56],"associated":[57],"with":[58,128,135],"eight-fold":[60],"increase":[61],"minimal":[63],"inhibitory":[64],"concentration":[65],"(MIC)":[66],"which":[68],"may":[69],"be":[70],"responsible":[71],"for":[72,156],"the":[73,88,147],"half-lives":[76],"on":[77],"pharmacokinetic":[78],"studies.":[79],"Unlike":[80],"daptomycin,":[81],"activity":[83,122],"not":[85,124],"reduced":[86],"presence":[89],"lung":[91],"surfactant.":[92],"short":[96],"post-antibiotic":[97],"effect":[98],"1\u00b71":[100],"hours":[101],"methicillin-susceptible":[103],"aureus":[105,110],"(MSSA)":[106],"methicillin-resistant":[108],"(MRSA)":[111],"following":[112],"4-hour":[114],"exposure":[115],"period.":[116],"The":[117],"unique":[119],"spectrum":[120],"compromised":[125],"by":[126],"interactions":[127],"major":[129],"antibiotic":[130],"classes,":[131],"but":[132],"demonstrates":[133],"synergy":[134],"low":[136],"concentrations":[137],"gentamicin":[139],"MSSA":[141],"MRSA.":[143],"These":[144],"studies":[145],"support":[146],"continued":[148],"investigation":[149],"as":[152],"targeted":[154],"therapeutic":[155],"staphylococcal":[157],"infections.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
