{"id":"https://openalex.org/W2013515157","doi":"https://doi.org/10.1074/jbc.m005724200","title":"Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-\u03b2-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells","display_name":"Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-\u03b2-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2013515157","doi":"https://doi.org/10.1074/jbc.m005724200","mag":"2013515157","pmid":"https://pubmed.ncbi.nlm.nih.gov/11278290"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m005724200","doi":"https://doi.org/10.1074/jbc.m005724200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m005724200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m005724200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044404375","display_name":"Hideto Watanabe","orcid":"https://orcid.org/0000-0001-5291-0696","observed_orcids":["https://orcid.org/0000-0001-5291-0696"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideto Watanabe","raw_affiliation_strings":["Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA","\u2021Craniofacial Developmental Biology and Regeneration Branch, NIDCR and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"\u2021Craniofacial Developmental Biology and Regeneration Branch, NIDCR and","institution_ids":["https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111805202","display_name":"Mark P. de Caestecker","orcid":"https://orcid.org/0000-0001-7926-1673","observed_orcids":["https://orcid.org/0000-0001-7926-1673"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. de Caestecker","raw_affiliation_strings":["From the Craniofacial Developmental Biology and Regeneration Branch, NIDCR and","\u00b6Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Craniofacial Developmental Biology and Regeneration Branch, NIDCR and","institution_ids":["https://openalex.org/I4210088259"]},{"raw_affiliation_string":"\u00b6Laboratory of Cell Regulation and Carcinogenesis, NCI, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102398216","display_name":"Yoshihiko Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoshihiko Yamada","raw_affiliation_strings":["\u2021Craniofacial Developmental Biology and Regeneration Branch, NIDCR and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021Craniofacial Developmental Biology and Regeneration Branch, NIDCR and","institution_ids":["https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102398216"],"corresponding_institution_ids":["https://openalex.org/I4210088259"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.0986,"has_fulltext":false,"cited_by_count":273,"citation_normalized_percentile":{"value":0.98116239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"276","issue":"17","first_page":"14466","last_page":"14473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7799999713897705},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9179999828338623},{"id":"https://openalex.org/keywords/p38-mapk-pathway","display_name":"p38 MAPK pathway","score":0.9449999928474426},{"id":"https://openalex.org/keywords/transcriptional-crosstalk","display_name":"transcriptional crosstalk","score":0.968999981880188},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/atdc5-cells","display_name":"ATDC5 cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/smad2-phosphorylation","display_name":"Smad2 phosphorylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.7429999709129333},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cartilage-specific-gene-expression","display_name":"cartilage-specific gene expression","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.7397418022155762},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.7005816102027893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5775858759880066},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5396679639816284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5207488536834717},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4715157747268677},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4229682385921478},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4129617214202881},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4118487536907196},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34114617109298706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23458144068717957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06993767619132996},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011500","descriptor_name":"Protein Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m005724200","doi":"https://doi.org/10.1074/jbc.m005724200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m005724200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11278290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11278290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m005724200","doi":"https://doi.org/10.1074/jbc.m005724200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m005724200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W189733190","https://openalex.org/W1515719112","https://openalex.org/W1521905573","https://openalex.org/W1532921008","https://openalex.org/W1533133582","https://openalex.org/W1544751778","https://openalex.org/W1605681980","https://openalex.org/W1663371441","https://openalex.org/W1799530333","https://openalex.org/W1963714463","https://openalex.org/W1965425054","https://openalex.org/W1970127647","https://openalex.org/W1971846249","https://openalex.org/W1972098727","https://openalex.org/W1974078926","https://openalex.org/W1978327680","https://openalex.org/W1983795715","https://openalex.org/W1985434939","https://openalex.org/W1992618022","https://openalex.org/W2005151588","https://openalex.org/W2005792688","https://openalex.org/W2006636734","https://openalex.org/W2007044718","https://openalex.org/W2010500335","https://openalex.org/W2014563658","https://openalex.org/W2020312178","https://openalex.org/W2021006097","https://openalex.org/W2021263701","https://openalex.org/W2023448881","https://openalex.org/W2027932074","https://openalex.org/W2032731042","https://openalex.org/W2034339135","https://openalex.org/W2039022971","https://openalex.org/W2043898015","https://openalex.org/W2045005503","https://openalex.org/W2048355846","https://openalex.org/W2051540590","https://openalex.org/W2059011972","https://openalex.org/W2065584680","https://openalex.org/W2066358298","https://openalex.org/W2069911905","https://openalex.org/W2070470162","https://openalex.org/W2071029740","https://openalex.org/W2071835467","https://openalex.org/W2082760271","https://openalex.org/W2086262311","https://openalex.org/W2088633520","https://openalex.org/W2093955502","https://openalex.org/W2098097317","https://openalex.org/W2101408271","https://openalex.org/W2102385086","https://openalex.org/W2102868284","https://openalex.org/W2119727612","https://openalex.org/W2124636374","https://openalex.org/W2131261731","https://openalex.org/W2131871435","https://openalex.org/W2142332666","https://openalex.org/W2145589640","https://openalex.org/W2148664347","https://openalex.org/W2156681756","https://openalex.org/W2164218605","https://openalex.org/W4211112402","https://openalex.org/W4235438234"],"related_works":["https://openalex.org/W7098671675","https://openalex.org/W1569205135","https://openalex.org/W2156733069","https://openalex.org/W1983795715","https://openalex.org/W2078213186","https://openalex.org/W6891774090","https://openalex.org/W2047956044","https://openalex.org/W2072177996","https://openalex.org/W1988582146","https://openalex.org/W2185143765"],"abstract_inverted_index":{"In":[0,158],"chondrogenesis,":[1],"members":[2],"of":[3,17,36,74,88,117,124,166,185,201,217,238,249],"the":[4,29,37,89,118,125,198,214,247],"transforming":[5],"growth":[6],"factor-beta":[7],"(TGF-beta)":[8],"superfamily":[9],"play":[10],"critical":[11],"roles":[12],"by":[13,92,181,193],"inducing":[14],"gene":[15,39],"expression":[16,35,46,135,153,203,237,251],"cartilage-specific":[18],"molecules.":[19],"By":[20],"using":[21],"a":[22,95,137],"chondrogenic":[23],"cell":[24],"line,":[25],"ATDC5,":[26],"we":[27],"investigated":[28],"TGF-beta-mediated":[30],"signaling":[31,108],"pathways":[32,91,235],"involved":[33,196],"in":[34,136,154,197,204,236,246],"aggrecan":[38],"(Agc).":[40],"At":[41,66],"confluency,":[42],"TGF-beta":[43,69,194],"induced":[44,70],"Agc":[45,103,134,152,176,202,218,250],"within":[47],"3":[48],"h,":[49],"and":[50,81,130,168,195,233,242],"cycloheximide":[51],"blocked":[52],"this":[53,64,67,112],"induction,":[54],"indicating":[55,105,140],"that":[56,106,141],"de":[57],"novo":[58],"protein":[59,84],"synthesis":[60],"is":[61,109,147],"essential":[62,110],"for":[63,111,150,212,228],"response.":[65,113],"stage,":[68],"rapid,":[71],"transient":[72],"phosphorylation":[73,171],"Smad2,":[75],"extracellular":[76],"signal-activated":[77],"kinase":[78,85],"1/2":[79],"(ERK1/2),":[80],"p38":[82,126,144,169],"mitogen-activated":[83],"(MAPK).":[86],"Inhibition":[87],"Smad":[90,107,232],"transfection":[93],"with":[94,173,183],"dominant":[96],"negative":[97],"Smad4":[98],"construct":[99],"significantly":[100],"reduced":[101],"TGF-beta-induced":[102,133,151],"expression,":[104,177],"Furthermore,":[114],"an":[115,225],"inhibitor":[116],"ERK1/2":[119,142,167],"pathway,":[120,128],"U0126,":[121],"or":[122,143],"inhibitors":[123,184],"MAPK":[127,145,170,234],"SB203580":[129],"SKF86002,":[131],"repressed":[132],"dose-dependent":[138],"manner,":[139],"activation":[146,200,208],"also":[148],"required":[149,211],"confluent":[155,205],"ATDC5":[156,160],"cells.":[157],"differentiated":[159],"cells,":[161,206],"persistently":[162],"high":[163,215],"basal":[164,175],"levels":[165],"correlated":[172],"elevated":[174],"which":[178],"was":[179,190,209],"inhibited":[180],"incubation":[182],"these":[186,222],"pathways.":[187],"Whereas":[188],"Smad2":[189,207],"rapidly":[191],"phosphorylated":[192],"initial":[199],"not":[210],"maintaining":[213],"level":[216],"expression.":[219],"Taken":[220],"together,":[221],"results":[223],"suggest":[224],"important":[226,244],"role":[227],"transcriptional":[229],"cross-talk":[230],"between":[231],"early":[239],"chondrocytic":[240],"phenotypes":[241],"identify":[243],"changes":[245],"regulation":[248],"following":[252],"chondrocyte":[253],"differentiation.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
