{"id":"https://openalex.org/W2013496283","doi":"https://doi.org/10.3727/096368911x637371","title":"LMP-420, a Small Molecular Inhibitor of TNF-\u03b1, Prolongs Islet Allograft Survival by Induction of Suppressor of Cytokine Signaling-1: Synergistic Effect with Cyclosporin-A","display_name":"LMP-420, a Small Molecular Inhibitor of TNF-\u03b1, Prolongs Islet Allograft Survival by Induction of Suppressor of Cytokine Signaling-1: Synergistic Effect with Cyclosporin-A","publication_year":2012,"publication_date":"2012-04-02","ids":{"openalex":"https://openalex.org/W2013496283","doi":"https://doi.org/10.3727/096368911x637371","mag":"2013496283","pmid":"https://pubmed.ncbi.nlm.nih.gov/22469483"},"language":"en","primary_location":{"id":"doi:10.3727/096368911x637371","doi":"https://doi.org/10.3727/096368911x637371","is_oa":false,"landing_page_url":"https://doi.org/10.3727/096368911x637371","pdf_url":null,"source":{"id":"https://openalex.org/S165333527","display_name":"Cell Transplantation","issn_l":"0963-6897","issn":["0963-6897","1555-3892"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=5359&context=open_access_pubs","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079368182","display_name":"Nataraju Angaswamy","orcid":"https://orcid.org/0009-0004-6010-1011","observed_orcids":["https://orcid.org/0009-0004-6010-1011"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nataraju Angaswamy","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081383505","display_name":"Naohiko Fukami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naohiko Fukami","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057225912","display_name":"Venkataswarup Tiriveedhi","orcid":"https://orcid.org/0000-0003-4708-5905","observed_orcids":["https://orcid.org/0000-0003-4708-5905"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkataswarup Tiriveedhi","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103327564","display_name":"George J. Cianciolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George J. Cianciolo","raw_affiliation_strings":["Department of Pathology, Duke University Medical Center, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109858661","display_name":"Thalachallour Mohanakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"T. Mohanakumar","raw_affiliation_strings":["Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109858661"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.2059,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.57110471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"21","issue":"6","first_page":"1285","last_page":"1296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/islet-allograft-survival","display_name":"islet allograft survival","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9020000100135803},{"id":"https://openalex.org/keywords/socs1","display_name":"SOCS1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.8159999847412109},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9710000157356262},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.8460000157356262},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.7229999899864197},{"id":"https://openalex.org/keywords/anti-apoptotic-mechanisms","display_name":"anti-apoptotic mechanisms","score":0.7960000038146973},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.6890000104904175},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8670247793197632},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6196209788322449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.575803279876709},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5556252598762512},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5417036414146423},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5197803378105164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5122391581535339},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43452855944633484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33212000131607056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2954063415527344},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2614489495754242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18443432450294495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071222","descriptor_name":"Suppressor of Cytokine Signaling 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001896","descriptor_name":"Boron Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3727/096368911x637371","doi":"https://doi.org/10.3727/096368911x637371","is_oa":false,"landing_page_url":"https://doi.org/10.3727/096368911x637371","pdf_url":null,"source":{"id":"https://openalex.org/S165333527","display_name":"Cell Transplantation","issn_l":"0963-6897","issn":["0963-6897","1555-3892"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Transplantation","raw_type":"journal-article"},{"id":"pmid:22469483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22469483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5359","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4352","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=5359&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a110cd6f17c440dd913d2ccd0000d795","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a110cd6f17c440dd913d2ccd0000d795","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Transplantation, Vol 21 (2012)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5359","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4352","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=5359&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013496283.pdf","grobid_xml":"https://content.openalex.org/works/W2013496283.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1752045965","https://openalex.org/W1830629339","https://openalex.org/W1968627893","https://openalex.org/W1969337837","https://openalex.org/W1974609577","https://openalex.org/W1974802817","https://openalex.org/W1978824708","https://openalex.org/W1982916524","https://openalex.org/W1986141117","https://openalex.org/W1988107589","https://openalex.org/W1988403455","https://openalex.org/W1989245068","https://openalex.org/W1990885498","https://openalex.org/W1992153017","https://openalex.org/W1995595371","https://openalex.org/W2002709285","https://openalex.org/W2003766305","https://openalex.org/W2007412207","https://openalex.org/W2019984014","https://openalex.org/W2021549782","https://openalex.org/W2023578997","https://openalex.org/W2031808487","https://openalex.org/W2033285967","https://openalex.org/W2037295277","https://openalex.org/W2041184891","https://openalex.org/W2056517528","https://openalex.org/W2058455617","https://openalex.org/W2064005803","https://openalex.org/W2070408704","https://openalex.org/W2073342144","https://openalex.org/W2082694978","https://openalex.org/W2089514678","https://openalex.org/W2092509331","https://openalex.org/W2093223464","https://openalex.org/W2094472907","https://openalex.org/W2106068833","https://openalex.org/W2106210346","https://openalex.org/W2108088303","https://openalex.org/W2108255115","https://openalex.org/W2133186034","https://openalex.org/W2136127635","https://openalex.org/W2144965623","https://openalex.org/W2146433875","https://openalex.org/W2153574228","https://openalex.org/W2154507669","https://openalex.org/W2165664819","https://openalex.org/W2328786770","https://openalex.org/W2336153715","https://openalex.org/W2340948203","https://openalex.org/W2402171262"],"related_works":["https://openalex.org/W162795270","https://openalex.org/W2018789118","https://openalex.org/W4386168072","https://openalex.org/W1544786528","https://openalex.org/W4319059988","https://openalex.org/W4320895639","https://openalex.org/W1974448124","https://openalex.org/W2075793871","https://openalex.org/W1971898029","https://openalex.org/W4308923260"],"abstract_inverted_index":{"Inflammatory":[0],"insults":[1],"following":[2],"islet":[3,44,217],"transplantation":[4],"(ITx)":[5],"hinders":[6],"engraftment":[7,45,219],"and":[8,34,46,72,75,151,172,188,191,212,220],"long-term":[9],"function":[10],"of":[11,20,26,70,84,185,194,210],"the":[12,24,38,58,146,208],"transplanted":[13],"(Tx)":[14],"islets.":[15],"Using":[16],"a":[17,28,114,152,166],"murine":[18],"model":[19],"ITx,":[21],"we":[22],"determined":[23],"role":[25],"LMP-420,":[27],"novel":[29],"TNF-\u03b1":[30,155,173],"inhibitor,":[31],"both":[32,170],"individually":[33],"in":[35,43,113,117,142,145,154,160,165,169,178,207],"combination":[36,69],"with":[37,53,157,176,204],"immunosuppressant":[39],"cyclosporine":[40],"A":[41],"(CSA)":[42],"survival.":[47,221],"Diabetic":[48],"C57BL/6":[49],"mice":[50],"were":[51,63],"Tx":[52],"500":[54],"BALB/c":[55],"islets":[56],"under":[57],"kidney":[59],"capsule.":[60],"Four":[61],"cohorts":[62],"used:":[64],"LMP-420":[65,71,139,202],"only,":[66,68],"CSA":[67,73,205],"(LMP+CSA),":[74],"control":[76,102],"(n":[77],"=":[78],"12":[79],"per":[80],"cohort).":[81],"Serial":[82],"monitoring":[83],"blood":[85,97],"glucose":[86],"levels":[87,99],"revealed":[88,137],"that":[89,109,138],"LMP+CSA":[90],"(35":[91],"\u00b1":[92,104,123,128],"5":[93],"days)":[94],"prolonged":[95],"stable":[96],"insulin":[98],"compared":[100],"to":[101],"(6":[103],"4":[105],"days).":[106],"Immunohistology":[107],"demonstrated":[108,183],"coadministration":[110,163],"(LMP+CSA)":[111],"results":[112,206],"significant":[115,192],"decrease":[116,153,168],"CD8(+)":[118],"T-cell":[119],"infiltration":[120],"(LMP+CSA:":[121],"31":[122],"18":[124],"vs.":[125],"control:":[126],"224":[127],"51":[129],"cells,":[130],"p":[131],"<":[132,198],"0.001).":[133],"Serum":[134],"cytokine":[135,148],"analysis":[136],"administration":[140,203],"resulted":[141,164],"an":[143],"increase":[144,177,184],"anti-inflammatory":[147,211],"IL-10":[149,179],"(2.5-fold),":[150],"(threefold)":[156,174],"no":[158],"change":[159],"IL-2.":[161],"However,":[162],"marked":[167],"IL-2":[171],"along":[175],"(threefold).":[180],"Coadministration":[181],"also":[182],"antiapoptotic":[186,213],"SOCS-1":[187],"Mn-SOD":[189],"expression":[190],"reduction":[193],"donor-specific":[195],"antibodies":[196],"(p":[197],"0.005).":[199],"In":[200],"conclusion,":[201],"upregulation":[209],"mechanisms":[214],"which":[215],"facilitate":[216],"allograft":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
