{"id":"https://openalex.org/W2013483540","doi":"https://doi.org/10.1634/stemcells.2005-0038","title":"Generation of Peripheral Sensory and Sympathetic Neurons and Neural Crest Cells from Human Embryonic Stem Cells","display_name":"Generation of Peripheral Sensory and Sympathetic Neurons and Neural Crest Cells from Human Embryonic Stem Cells","publication_year":2005,"publication_date":"2005-05-10","ids":{"openalex":"https://openalex.org/W2013483540","doi":"https://doi.org/10.1634/stemcells.2005-0038","mag":"2013483540","pmid":"https://pubmed.ncbi.nlm.nih.gov/15883233"},"language":"en","primary_location":{"id":"doi:10.1634/stemcells.2005-0038","doi":"https://doi.org/10.1634/stemcells.2005-0038","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0038","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012529643","display_name":"Oz Pomp","orcid":"https://orcid.org/0000-0001-8697-5498","observed_orcids":["https://orcid.org/0000-0001-8697-5498"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oz Pomp","raw_affiliation_strings":["Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016197443","display_name":"Irina Brokhman","orcid":"https://orcid.org/0000-0002-9824-1456","observed_orcids":["https://orcid.org/0000-0002-9824-1456"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Irina Brokhman","raw_affiliation_strings":["Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026712484","display_name":"Israel Ben\u2010Dor","orcid":"https://orcid.org/0000-0002-9745-5196","observed_orcids":["https://orcid.org/0000-0002-9745-5196"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Israel Ben\u2010Dor","raw_affiliation_strings":["The Hadassah Human Embryonic Stem Cell Research Center, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hadassah Human Embryonic Stem Cell Research Center, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058749953","display_name":"Benjamin E. Reubinoff","orcid":"https://orcid.org/0000-0003-0353-1299","observed_orcids":["https://orcid.org/0000-0003-0353-1299"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Benjamin Reubinoff","raw_affiliation_strings":["The Hadassah Human Embryonic Stem Cell Research Center, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hadassah Human Embryonic Stem Cell Research Center, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084376477","display_name":"Ronald S. Goldstein","orcid":"https://orcid.org/0000-0002-2907-7971","observed_orcids":["https://orcid.org/0000-0002-2907-7971"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ronald S. Goldstein","raw_affiliation_strings":["Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, Bar\u2010Ilan University, Ramat\u2010Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084376477"],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":3.82,"has_fulltext":true,"cited_by_count":189,"citation_normalized_percentile":{"value":0.94712841,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"23","issue":"7","first_page":"923","last_page":"930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/peripheral-sensory-neurons","display_name":"peripheral sensory neurons","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sympathetic-neurons","display_name":"sympathetic neurons","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neural-crest-cells","display_name":"neural crest cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.8299999833106995},{"id":"https://openalex.org/keywords/peripherin","display_name":"peripherin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/brn3a","display_name":"Brn3a","score":0.972000002861023},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dhand","display_name":"dHAND","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neural-crest-markers","display_name":"neural crest markers","score":0.8009999990463257},{"id":"https://openalex.org/keywords/familial-dysautonomia","display_name":"familial dysautonomia","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8461560010910034},{"id":"https://openalex.org/C28521208","wikidata":"https://www.wikidata.org/wiki/Q14864874","display_name":"Peripherin","level":3,"score":0.7915868759155273},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7557446956634521},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.7158955335617065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5892178416252136},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5350905656814575},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4757556617259979},{"id":"https://openalex.org/C2777117487","wikidata":"https://www.wikidata.org/wiki/Q18811569","display_name":"Directed differentiation","level":5,"score":0.44513756036758423},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.43344181776046753},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4118030071258545},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3332836627960205},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.2548983693122864},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2473180890083313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11582842469215393},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08069765567779541},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.07995840907096863}],"mesh":[{"descriptor_ui":"D000071250","descriptor_name":"Snail Family Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1634/stemcells.2005-0038","doi":"https://doi.org/10.1634/stemcells.2005-0038","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2005-0038","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:15883233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15883233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306678","display_name":"Dysautonomia Foundation","ror":"https://ror.org/04nqwsb31"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320321449","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495"},{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W961549952","https://openalex.org/W1565566882","https://openalex.org/W1960472109","https://openalex.org/W1965409424","https://openalex.org/W1966476278","https://openalex.org/W1971833191","https://openalex.org/W1987402927","https://openalex.org/W1988865085","https://openalex.org/W1989326240","https://openalex.org/W2005296007","https://openalex.org/W2005707140","https://openalex.org/W2011928329","https://openalex.org/W2013589301","https://openalex.org/W2021052173","https://openalex.org/W2043300325","https://openalex.org/W2051409010","https://openalex.org/W2066201777","https://openalex.org/W2100388117","https://openalex.org/W2126789530","https://openalex.org/W2138442302","https://openalex.org/W2139565721","https://openalex.org/W2150153438","https://openalex.org/W2152893516","https://openalex.org/W2155900909","https://openalex.org/W2332835754","https://openalex.org/W4250943273"],"related_works":["https://openalex.org/W1990975476","https://openalex.org/W2001381643","https://openalex.org/W2803688812","https://openalex.org/W121885701","https://openalex.org/W2196679915","https://openalex.org/W3088863410","https://openalex.org/W2036786455","https://openalex.org/W2310733555","https://openalex.org/W2360437973","https://openalex.org/W2051550082"],"abstract_inverted_index":{"Human":[0],"embryonic":[1,60],"stem":[2,61],"cells":[3,12,20,62,135,138,213],"(hESCs)":[4],"have":[5,24,33],"been":[6,25,34],"directed":[7],"to":[8,63,160,172,184],"differentiate":[9],"into":[10],"neuronal":[11,65,140],"using":[13],"many":[14],"cell-culture":[15],"techniques.":[16],"Central":[17],"nervous":[18],"system":[19,227],"with":[21,73],"clinical":[22],"importance":[23],"produced":[26],"from":[27,43,67,114],"hESCs.":[28,44,68],"To":[29],"date,":[30],"however,":[31],"there":[32],"no":[35],"definitive":[36],"reports":[37],"of":[38,40,49,52,99,120,122,157,166,179,193,208,211],"generation":[39],"peripheral":[41,100,108,250],"neurons":[42,82,112,251],"We":[45],"used":[46,230],"a":[47],"modification":[48],"the":[50,74,115,133,164,203,206,238],"method":[51],"Sasai":[53],"and":[54,58,89,91,94,102,110,150,218,234],"colleagues":[55],"for":[56,79,231,246,252,255],"mouse":[57,75],"primate":[59],"elicit":[64],"differentiation":[66,141,178],"When":[69],"hESCs":[70],"are":[71,83,152],"cocultured":[72],"stromal":[76],"line":[77],"PA6":[78,134],"3":[80,191],"weeks,":[81],"induced":[84],"that":[85,132,225],"coexpress":[86],"(a)":[87],"peripherin":[88,93],"Brn3a,":[90],"(b)":[92],"tyrosine":[95],"hydroxylase,":[96],"combinations":[97],"characteristic":[98],"sensory":[101,109],"sympathetic":[103,111],"neurons,":[104],"respectively.":[105],"In":[106],"vivo,":[107],"develop":[113],"neural":[116],"crest":[117],"(NC).":[118],"Analysis":[119],"expression":[121,165,207],"mRNAs":[123],"identified":[124],"in":[125,176,214,216,219,237],"other":[126],"species":[127],"as":[128,243,245,258],"NC":[129,145,168,180],"markers":[130,210],"reveals":[131],"induce":[136],"NC-like":[137,212],"before":[139],"takes":[142],"place.":[143],"Several":[144],"markers,":[146],"including":[147],"SNAIL,":[148],"dHAND,":[149],"Sox9,":[151],"increased":[153],"at":[154,187,190,197],"1":[155,198],"week":[156],"coculture":[158,195],"relative":[159],"naive":[161],"cells.":[162],"Furthermore,":[163],"several":[167],"marker":[169],"genes":[170],"known":[171],"be":[173,185,229],"downregulated":[174],"upon":[175],"vivo":[177],"derivatives,":[181],"was":[182],"observed":[183],"present":[186],"lower":[188],"levels":[189],"weeks":[192],"PA6-hESC":[194],"than":[196],"week.":[199],"Our":[200,222],"report":[201],"is":[202],"first":[204],"on":[205],"molecular":[209,233],"primates,":[215],"general,":[217],"humans,":[220],"specifically.":[221],"results":[223],"suggest":[224],"this":[226],"can":[228],"studying":[232],"cellular":[235],"events":[236],"almost":[239],"inaccessible":[240],"human":[241,249],"NC,":[242],"well":[244],"producing":[247],"normal":[248],"developing":[253],"therapies":[254],"diseases":[256],"such":[257],"familial":[259],"dysautonomia.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}