{"id":"https://openalex.org/W2013482334","doi":"https://doi.org/10.1097/00001756-200112210-00006","title":"Lead content of brain tissue in diffuse neurofibrillary tangles with calcification (DNTC): the possibility of lead neurotoxicity","display_name":"Lead content of brain tissue in diffuse neurofibrillary tangles with calcification (DNTC): the possibility of lead neurotoxicity","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2013482334","doi":"https://doi.org/10.1097/00001756-200112210-00006","mag":"2013482334","pmid":"https://pubmed.ncbi.nlm.nih.gov/11742204"},"language":"en","primary_location":{"id":"doi:10.1097/00001756-200112210-00006","doi":"https://doi.org/10.1097/00001756-200112210-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200112210-00006","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019933268","display_name":"Takashi Haraguchi","orcid":"https://orcid.org/0000-0003-1418-8916","observed_orcids":["https://orcid.org/0000-0003-1418-8916"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Haraguchi","raw_affiliation_strings":["Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112400158","display_name":"Hideki Ishizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256462","display_name":"Zikei Institute of Psychiatry","ror":"https://ror.org/046jrga91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256462"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Ishizu","raw_affiliation_strings":["00-2 Urayasuhon-machi, Okayama, 702-8026","Zikei Institute of Psychiatry, Zikei Mental Hospital, 100-2 Urayasuhon-machi, Okayama, 702-8026;","Zikei Mental Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"00-2 Urayasuhon-machi, Okayama, 702-8026","institution_ids":[]},{"raw_affiliation_string":"Zikei Institute of Psychiatry, Zikei Mental Hospital, 100-2 Urayasuhon-machi, Okayama, 702-8026;","institution_ids":["https://openalex.org/I4405256462"]},{"raw_affiliation_string":"Zikei Mental Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088866231","display_name":"Yasushi Takehisa","orcid":"https://orcid.org/0000-0002-0537-0727","observed_orcids":["https://orcid.org/0000-0002-0537-0727"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Takehisa","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101482460","display_name":"Kensuke Kawai","orcid":"https://orcid.org/0000-0002-8218-7360","observed_orcids":["https://orcid.org/0000-0002-8218-7360"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensuke Kawai","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055763749","display_name":"Osamu Yokota","orcid":"https://orcid.org/0000-0003-2990-7952","observed_orcids":["https://orcid.org/0000-0003-2990-7952"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Yokota","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026186133","display_name":"Seishi Terada","orcid":"https://orcid.org/0000-0002-5771-6582","observed_orcids":["https://orcid.org/0000-0002-5771-6582"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seishi Terada","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000693756","display_name":"Kuniaki Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I2801966156","display_name":"Tokyo Metropolitan Matsuzawa Hospital","ror":"https://ror.org/037yff262","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2801966156"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuniaki Tsuchiya","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Tokyo Metropolitan Institute of Medical Science","Tokyo Metropolitan Matsuzawa Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science","institution_ids":["https://openalex.org/I4210098918"]},{"raw_affiliation_string":"Tokyo Metropolitan Matsuzawa Hospital","institution_ids":["https://openalex.org/I2801966156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001102818","display_name":"Kenji Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210098918","display_name":"Tokyo Metropolitan Institute of Medical Science","ror":"https://ror.org/00vya8493","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210098918"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Ikeda","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Tokyo Metropolitan Institute of Medical Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Tokyo Metropolitan Institute of Medical Science;","institution_ids":["https://openalex.org/I4210098918"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keijirou Morita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4405256779","display_name":"Okayama Prefectural Institute for Environmental Science and Public Health","ror":"https://ror.org/04h9pf148","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256779"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keijirou Morita","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama Prefectural Institute for Environmental Science and Public Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama Prefectural Institute for Environmental Science and Public Health","institution_ids":["https://openalex.org/I4405256779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002980899","display_name":"Tokushi Horike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokushi Horike","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Junpukai Health Maintenance Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Junpukai Health Maintenance Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110136640","display_name":"Shohei Kira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Kira","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113574247","display_name":"Shigetoshi Kuroda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigetoshi Kuroda","raw_affiliation_strings":["Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","Okayama University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry and 6Public Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama, 700-8558","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019933268"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":0.8298,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.66980291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"18","first_page":"3887","last_page":"3890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-neurotoxicity","display_name":"lead neurotoxicity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/early-onset-dementia","display_name":"early-onset dementia","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neuropil-threads","display_name":"neuropil threads","score":0.9070000052452087},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/heavy-metal-exposure","display_name":"heavy metal exposure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.7333613634109497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7204573750495911},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.6256715059280396},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5992295742034912},{"id":"https://openalex.org/C2779721402","wikidata":"https://www.wikidata.org/wiki/Q767442","display_name":"Neurofibrillary tangle","level":5,"score":0.5665876865386963},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.5146065950393677},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5069983005523682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48600658774375916},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.47462642192840576},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4388248920440674},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.41906023025512695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3280295729637146},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.271859347820282},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21368595957756042},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21182718873023987},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18749284744262695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1682225465774536},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.14234375953674316}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002114","descriptor_name":"Calcinosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005404","descriptor_name":"Fixatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013054","descriptor_name":"Spectrophotometry, Atomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020263","descriptor_name":"Lead Poisoning, Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D024801","descriptor_name":"Tauopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001756-200112210-00006","doi":"https://doi.org/10.1097/00001756-200112210-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200112210-00006","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"journal-article"},{"id":"pmid:11742204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11742204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1586376900","https://openalex.org/W1851778146","https://openalex.org/W1970314665","https://openalex.org/W1980201990","https://openalex.org/W2016330834","https://openalex.org/W2030394192","https://openalex.org/W2038545588","https://openalex.org/W2061802612","https://openalex.org/W2077342896","https://openalex.org/W2077481531","https://openalex.org/W2081419657","https://openalex.org/W2119422439","https://openalex.org/W2172007938","https://openalex.org/W2253763976","https://openalex.org/W2292953105","https://openalex.org/W2417073423","https://openalex.org/W2474581649","https://openalex.org/W2891215035","https://openalex.org/W4211114415"],"related_works":["https://openalex.org/W1980201990","https://openalex.org/W2082827216","https://openalex.org/W5375672","https://openalex.org/W2414321366","https://openalex.org/W2016330834","https://openalex.org/W1988325382","https://openalex.org/W2168498752","https://openalex.org/W1590596314","https://openalex.org/W1970314665","https://openalex.org/W2735424659"],"abstract_inverted_index":{"Diffuse":[0],"neurofibrillary":[1,18],"tangles":[2,19],"with":[3,17],"calcification":[4],"(DNTC)":[5],"is":[6],"a":[7,107],"form":[8],"of":[9,44,48,72,87,91,110,127,140],"presenile":[10],"dementia,":[11],"characterized":[12],"pathologically":[13],"by":[14,100],"fronto-temporal":[15],"atrophy":[16],"(NFTs),":[20],"neuropil":[21],"threads":[22],"and":[23,78,94,105],"Fahr-type":[24,49],"calcification,":[25],"in":[26,58,65,74,79,95,112,137],"which":[27,59],"no":[28,56],"senile":[29],"plaques":[30],"are":[31,122],"observed.":[32],"As":[33],"already":[34],"noted,":[35],"chronic":[36],"exposure":[37],"to":[38,124],"lead":[39],"(Pb)":[40],"might":[41],"be":[42,135],"one":[43],"the":[45,70,125,138],"etiological":[46],"factors":[47],"calcification.":[50],"Until":[51],"now,":[52],"there":[53],"have":[54],"been":[55,63],"reports":[57],"Pb":[60,73,111,132],"concentration":[61,71,109],"has":[62],"quantified":[64],"DNTC":[66,113],"brains.":[67,114],"We":[68],"examined":[69],"fresh-frozen":[75],"brain":[76,82],"tissue":[77,83],"10%":[80],"formalin-fixed":[81],"from":[84],"six":[85],"cases":[86,90],"DNTC,":[88],"four":[89],"Alzheimer's":[92],"disease,":[93],"nine":[96],"non-demented":[97],"elderly":[98],"controls":[99],"flameless":[101],"atomic":[102],"absorption":[103],"spectrometry,":[104],"demonstrated":[106],"high":[108],"Although":[115],"it":[116],"remains":[117],"unclear":[118],"how":[119],"these":[120],"findings":[121],"related":[123],"formation":[126],"NFTs,":[128],"they":[129],"suggest":[130],"that":[131],"neurotoxicity":[133],"may":[134],"involved":[136],"pathogenesis":[139],"DNTC.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}