{"id":"https://openalex.org/W2013467526","doi":"https://doi.org/10.1016/j.coph.2013.06.009","title":"Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease","display_name":"Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease","publication_year":2013,"publication_date":"2013-07-16","ids":{"openalex":"https://openalex.org/W2013467526","doi":"https://doi.org/10.1016/j.coph.2013.06.009","mag":"2013467526","pmid":"https://pubmed.ncbi.nlm.nih.gov/23871446"},"language":"en","primary_location":{"id":"doi:10.1016/j.coph.2013.06.009","doi":"https://doi.org/10.1016/j.coph.2013.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2013.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068938995","display_name":"Micheal S. Ward","orcid":"https://orcid.org/0000-0003-3921-6880","observed_orcids":["https://orcid.org/0000-0003-3921-6880"]},"institutions":[{"id":"https://openalex.org/I4210092543","display_name":"Mater Research","ror":"https://ror.org/00nx6aa03","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210092543"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Micheal S Ward","raw_affiliation_strings":["Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia. mward@mmri.mater.org.au","Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia. mward@mmri.mater.org.au","institution_ids":["https://openalex.org/I4210092543"]},{"raw_affiliation_string":"Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia","institution_ids":["https://openalex.org/I4210092543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071654627","display_name":"Amelia K. Fotheringham","orcid":"https://orcid.org/0000-0002-3213-8923","observed_orcids":["https://orcid.org/0000-0002-3213-8923"]},"institutions":[{"id":"https://openalex.org/I4210092543","display_name":"Mater Research","ror":"https://ror.org/00nx6aa03","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210092543"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amelia K Fotheringham","raw_affiliation_strings":["Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia","institution_ids":["https://openalex.org/I4210092543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062670268","display_name":"Mark Emmanuel Cooper","orcid":"https://orcid.org/0000-0001-7785-2488","observed_orcids":["https://orcid.org/0000-0001-7785-2488"]},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark E Cooper","raw_affiliation_strings":["Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Australia","Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Australia","institution_ids":["https://openalex.org/I142471025"]},{"raw_affiliation_string":"Glycation, Nutrition and Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia","institution_ids":["https://openalex.org/I142471025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011660710","display_name":"Josephine Maree Forbes","orcid":"https://orcid.org/0000-0002-5595-8174","observed_orcids":["https://orcid.org/0000-0002-5595-8174"]},"institutions":[{"id":"https://openalex.org/I4210092543","display_name":"Mater Research","ror":"https://ror.org/00nx6aa03","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210092543"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Josephine M Forbes","raw_affiliation_strings":["Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Glycation and Diabetic Complications, Mater Research, Brisbane, Queensland 4102, Australia","institution_ids":["https://openalex.org/I4210092543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068938995"],"corresponding_institution_ids":["https://openalex.org/I4210092543"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":0.5839,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.45890411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"4","first_page":"654","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.996999979019165},{"id":"https://openalex.org/keywords/receptor-for-advanced-glycation-end-products","display_name":"receptor for advanced glycation end products","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8050000071525574},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8749997615814209},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8680375814437866},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7353472113609314},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6314941644668579},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6111018657684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5604742169380188},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.5097002983093262},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4845237135887146},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4595872461795807},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4386543929576874},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4161801338195801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31028565764427185},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.283196359872818},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2188030183315277},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21494409441947937},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19544902443885803},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1311105191707611}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.coph.2013.06.009","doi":"https://doi.org/10.1016/j.coph.2013.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2013.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},{"id":"pmid:23871446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23871446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4764367589","display_name":null,"funder_award_id":"3-2013-217","funder_id":"https://openalex.org/F4320310820","funder_display_name":"Juvenile Diabetes Research Foundation United States of America"},{"id":"https://openalex.org/G7035350637","display_name":null,"funder_award_id":"3-2013-217","funder_id":"https://openalex.org/F4320306172","funder_display_name":"Juvenile Diabetes Research Foundation International"}],"funders":[{"id":"https://openalex.org/F4320306172","display_name":"Juvenile Diabetes Research Foundation International","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W285026020","https://openalex.org/W1512879776","https://openalex.org/W1832011285","https://openalex.org/W1963843984","https://openalex.org/W1966069109","https://openalex.org/W1968299608","https://openalex.org/W1974522038","https://openalex.org/W1974573093","https://openalex.org/W1976599148","https://openalex.org/W1986721569","https://openalex.org/W1995801352","https://openalex.org/W1997595033","https://openalex.org/W2002838140","https://openalex.org/W2008586394","https://openalex.org/W2011594751","https://openalex.org/W2013185491","https://openalex.org/W2016742756","https://openalex.org/W2020225229","https://openalex.org/W2020585998","https://openalex.org/W2028389992","https://openalex.org/W2028680000","https://openalex.org/W2036108303","https://openalex.org/W2041448730","https://openalex.org/W2042996707","https://openalex.org/W2056829852","https://openalex.org/W2057039546","https://openalex.org/W2058426249","https://openalex.org/W2066906004","https://openalex.org/W2067514854","https://openalex.org/W2073019915","https://openalex.org/W2099753885","https://openalex.org/W2109365673","https://openalex.org/W2115408859","https://openalex.org/W2116094406","https://openalex.org/W2116509909","https://openalex.org/W2127218697","https://openalex.org/W2129902595","https://openalex.org/W2130343300","https://openalex.org/W2130406668","https://openalex.org/W2135816525","https://openalex.org/W2140292484","https://openalex.org/W2143201143","https://openalex.org/W2145251947","https://openalex.org/W2148254624","https://openalex.org/W2148329662","https://openalex.org/W2149541479","https://openalex.org/W2151456999","https://openalex.org/W2152512217","https://openalex.org/W2153488117","https://openalex.org/W2154667004","https://openalex.org/W2156800327","https://openalex.org/W2158850050","https://openalex.org/W2159836149","https://openalex.org/W2159948606","https://openalex.org/W2160382989","https://openalex.org/W2162514497","https://openalex.org/W2164748564","https://openalex.org/W2165253883","https://openalex.org/W2171553260","https://openalex.org/W2171786511","https://openalex.org/W2413254135","https://openalex.org/W2473739348","https://openalex.org/W2581157121","https://openalex.org/W6720971836"],"related_works":["https://openalex.org/W2409031417","https://openalex.org/W4412869999","https://openalex.org/W4386862687","https://openalex.org/W4404080272","https://openalex.org/W2144184190","https://openalex.org/W4413869457","https://openalex.org/W591608355","https://openalex.org/W4292679885","https://openalex.org/W2322019005","https://openalex.org/W2898508325"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}