{"id":"https://openalex.org/W2013464322","doi":"https://doi.org/10.1016/j.canlet.2009.06.032","title":"Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells","display_name":"Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells","publication_year":2009,"publication_date":"2009-07-22","ids":{"openalex":"https://openalex.org/W2013464322","doi":"https://doi.org/10.1016/j.canlet.2009.06.032","mag":"2013464322","pmid":"https://pubmed.ncbi.nlm.nih.gov/19625121"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2009.06.032","doi":"https://doi.org/10.1016/j.canlet.2009.06.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2009.06.032","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087031696","display_name":"Wen\u2010Chun Hung","orcid":"https://orcid.org/0000-0003-4860-5415","observed_orcids":["https://orcid.org/0000-0003-4860-5415"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Chun Hung","raw_affiliation_strings":["Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088921509","display_name":"Wei\u2010Lung Tseng","orcid":"https://orcid.org/0000-0001-9808-5863","observed_orcids":["https://orcid.org/0000-0001-9808-5863"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Lung Tseng","raw_affiliation_strings":["Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029553705","display_name":"Jentaie Shiea","orcid":"https://orcid.org/0000-0002-7153-3029","observed_orcids":["https://orcid.org/0000-0002-7153-3029"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jentaie Shiea","raw_affiliation_strings":["Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352"]},{"raw_affiliation_string":"National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100830740","display_name":"Hui\u2010Chiu Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hui-Chiu Chang","raw_affiliation_strings":["Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC","National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"National Sun Yat-Sen University\u2013Kaohsiung Medical University Joint Research Center, Taiwan, ROC","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100830740"],"corresponding_institution_ids":["https://openalex.org/I142974352","https://openalex.org/I152743029"],"apc_list":{"value":4960,"currency":"USD","value_usd":4960},"apc_paid":null,"fwci":2.0511,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.87143328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"288","issue":"2","first_page":"156","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skp2","display_name":"Skp2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/p27-degradation","display_name":"p27 degradation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mithramycin","display_name":"mithramycin","score":0.7670000195503235},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7279676795005798},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7273437976837158},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6414344310760498},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6245142817497253},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5625954270362854},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5542113184928894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5371065735816956},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5126494765281677},{"id":"https://openalex.org/C2776787872","wikidata":"https://www.wikidata.org/wiki/Q18031516","display_name":"SKP2","level":5,"score":0.4943230152130127},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.45150598883628845},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4400601089000702},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4238702058792114},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.41425493359565735},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38989925384521484},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38180801272392273},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.380085289478302},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36218103766441345},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.231342613697052},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22427937388420105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20250189304351807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1634240448474884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08168002963066101},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05902543663978577},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008926","descriptor_name":"Plicamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2009.06.032","doi":"https://doi.org/10.1016/j.canlet.2009.06.032","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.canlet.2009.06.032","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:19625121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19625121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322811","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1558846872","https://openalex.org/W1574172480","https://openalex.org/W1969375564","https://openalex.org/W1971254046","https://openalex.org/W1981046858","https://openalex.org/W1988806762","https://openalex.org/W1991440608","https://openalex.org/W1994869819","https://openalex.org/W1997826997","https://openalex.org/W2008239830","https://openalex.org/W2011466019","https://openalex.org/W2013256513","https://openalex.org/W2017914530","https://openalex.org/W2028768078","https://openalex.org/W2032777069","https://openalex.org/W2056830691","https://openalex.org/W2060385362","https://openalex.org/W2071915670","https://openalex.org/W2074780626","https://openalex.org/W2077867380","https://openalex.org/W2080495834","https://openalex.org/W2098817749","https://openalex.org/W2102628825","https://openalex.org/W2125126707","https://openalex.org/W2126446233","https://openalex.org/W2128380182","https://openalex.org/W2132377214","https://openalex.org/W2135378702","https://openalex.org/W2149689548","https://openalex.org/W4236147141","https://openalex.org/W6658590567","https://openalex.org/W6668657896","https://openalex.org/W6679269960"],"related_works":["https://openalex.org/W2054455681","https://openalex.org/W1981046858","https://openalex.org/W2017187150","https://openalex.org/W2038080922","https://openalex.org/W2957403568","https://openalex.org/W985133341","https://openalex.org/W2020285793","https://openalex.org/W2058863407","https://openalex.org/W7100384861","https://openalex.org/W2030923410"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
