{"id":"https://openalex.org/W2013463987","doi":"https://doi.org/10.1158/1538-7445.am2012-3495","title":"Abstract 3495: The novel phospholipid ether analog CLR1404 decreases glioblastoma stem cell proliferation, suppresses GBM growth, and improves survival","display_name":"Abstract 3495: The novel phospholipid ether analog CLR1404 decreases glioblastoma stem cell proliferation, suppresses GBM growth, and improves survival","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2013463987","doi":"https://doi.org/10.1158/1538-7445.am2012-3495","mag":"2013463987"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3495","doi":"https://doi.org/10.1158/1538-7445.am2012-3495","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3495","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017967519","display_name":"Paul A. Clark","orcid":"https://orcid.org/0000-0002-1608-1146","observed_orcids":["https://orcid.org/0000-0002-1608-1146"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Clark","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong-En Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong-En Chen","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Mohamed","raw_affiliation_strings":["2University of Minnesota - Twin Cities, Minneapolis, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Minnesota - Twin Cities, Minneapolis, WI","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063400337","display_name":"Irawati K. Kandela","orcid":"https://orcid.org/0000-0002-8646-9357","observed_orcids":["https://orcid.org/0000-0002-8646-9357"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irawati K. Kandela","raw_affiliation_strings":["3Northwestern University, Evanston, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Northwestern University, Evanston, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020348391","display_name":"Marc A. Longino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc A. Longino","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anatoly Pinchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoly Pinchuk","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013731126","display_name":"Jamey P. Weichert","orcid":"https://orcid.org/0000-0002-2048-6381","observed_orcids":["https://orcid.org/0000-0002-2048-6381"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamey P. Weichert","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054371127","display_name":"John S. Kuo","orcid":"https://orcid.org/0000-0001-6809-4806","observed_orcids":["https://orcid.org/0000-0001-6809-4806"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Kuo","raw_affiliation_strings":["1University of Wisconsin, Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Wisconsin, Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3495","last_page":"3495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.859000027179718},{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8109999895095825},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.4950000047683716},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.7409999966621399},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6520000100135803},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6618067622184753},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5915617346763611},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5646560192108154},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4972441494464874},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.4910469055175781},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47912999987602234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45643460750579834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4494169354438782},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41751453280448914},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32937783002853394},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3214937448501587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31809985637664795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.286002516746521},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2345390021800995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17236274480819702},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.1135316789150238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10086709260940552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08844685554504395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3495","doi":"https://doi.org/10.1158/1538-7445.am2012-3495","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3495","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2742343928","https://openalex.org/W2899725472","https://openalex.org/W3161388446","https://openalex.org/W2667947057","https://openalex.org/W2548474258","https://openalex.org/W2055340768","https://openalex.org/W6965265996","https://openalex.org/W2900387801","https://openalex.org/W1994288024","https://openalex.org/W2018588230"],"abstract_inverted_index":{"Abstract":[0],"Most":[1],"patients":[2],"treated":[3,148],"for":[4,46,76,112,136,190,332,360],"glioblastoma":[5],"multiforme":[6],"(GBM),":[7],"the":[8,86,173,297,333,352,357],"most":[9],"common":[10],"primary":[11],"brain":[12],"malignancy,":[13],"have":[14],"less":[15],"than":[16],"2":[17],"years":[18],"survival":[19,207,280],"due":[20,73],"to":[21,36,74,152,165,196,339],"rapid":[22],"recurrence.":[23,39],"The":[24],"GBM":[25,92,223,311,341],"stem":[26,143],"cell":[27,67,78,144,320],"(GSC)":[28],"sub-population":[29],"exhibits":[30],"therapeutic":[31,87,308],"resistance":[32],"and":[33,53,61,69,93,109,116,163,222,312,325],"is":[34,43],"hypothesized":[35],"drive":[37],"tumor":[38,120,299,319],"Therefore,":[40],"GSC-specific":[41],"targeting":[42,321],"likely":[44],"critical":[45],"improving":[47],"outcome.":[48,303],"Phospholipid":[49],"ether":[50],"analog,":[51],"CLR1404":[52,90,132,170,194,212,248,264,274,294,324],"its":[54,94,313,326],"radioiodinated":[55],"isosteres,":[56,328],"exhibit":[57],"cancer":[58,66,77],"cell-specific":[59],"uptake":[60],"prolonged":[62],"retention":[63],"in":[64,122,133,159,178,282],"57/61":[65],"lines":[68,100,224,257],"xenografts":[70],"(including":[71],"GBM)":[72],"affinity":[75],"lipid":[79],"rafts.":[80],"In":[81,185],"this":[82],"study,":[83],"we":[84],"investigated":[85],"potential":[88,309,334],"of":[89,131,172,199,244,254,266,276,296,306,323,335,351,356],"against":[91,310],"GSC":[95,99,221,256,298],"subpopulation.":[96],"Multiple":[97],"sphere-forming":[98,252],"were":[101,127,147,188,209,215],"isolated":[102],"from":[103],"patient":[104],"specimens":[105],"with":[106,149,182,193,226,258,316],"IRB":[107],"approval,":[108],"rigorously":[110],"validated":[111],"self-renewal,":[113],"multi-lineage":[114],"potential,":[115],"high":[117],"efficiency":[118],"orthotopic":[119,197,284],"initiation":[121],"NOD-SCID":[123],"mice.":[124,205],"Proliferation":[125],"assays":[126],"performed":[128],"by":[129],"addition":[130],"serum-free":[134],"medium":[135],"24":[137,191],"hours.":[138],"To":[139],"test":[140],"effects":[141,214],"on":[142,217],"properties,":[145],"GSCs":[146,179,187,277],"CLR1404,":[150],"dissociated":[151],"single":[153],"cells,":[154],"plated":[155],"at":[156],"500":[157],"cells":[158,202,240,301],"a":[160],"96-well":[161],"plate,":[162],"allowed":[164],"form":[166],"spheres":[167],"(\u22652-4":[168],"weeks).":[169],"inhibition":[171,265],"AKT":[174,267],"oncogenic":[175],"signaling":[176],"pathway":[177],"was":[180,269],"assayed":[181],"immunoblot":[183,272],"analysis.":[184,273],"vivo,":[186],"pre-treated":[189],"hours":[192],"prior":[195],"injection":[198],"200,000":[200],"live":[201],"into":[203],"immunodeficient":[204],"Subsequent":[206],"curves":[208],"then":[210],"constructed.":[211],"anti-proliferative":[213],"seen":[216],"all":[218],"7":[219],"different":[220],"tested":[225],"IC50":[227,243,259],"values":[228,260],"ranging":[229],"between":[230,261],"5-10":[231,262],"\u00b5M":[232],"using":[233,271],"MTS":[234],"assay;":[235],"control":[236],"normal":[237],"differentiated":[238],"neural":[239],"exhibited":[241],"an":[242,283],"approximately":[245],"40":[246],"\u00b5M.":[247,263],"treatment":[249,295],"also":[250],"decreased":[251],"ability":[253],"multiple":[255],"activation":[268],"observed":[270],"pre-treatment":[275],"significantly":[278],"increased":[279],"time":[281],"mouse":[285],"model":[286],"(Control:":[287],"59\u00b16.1":[288],"days;":[289],"CLR1404:":[290],"94\u00b14.4":[291],"days),":[292],"suggesting":[293],"initiating":[300],"improves":[302],"This":[304],"data":[305],"CLR1404's":[307],"GSCs,":[314],"combined":[315],"previously":[317],"demonstrated":[318],"specificity":[322],"radioactive":[327],"provides":[329],"strong":[330],"evidence":[331],"novel":[336],"CLR1404-based":[337],"therapies":[338],"improve":[340],"outcomes.":[342],"Citation":[343],"Format:":[344],"{Authors}.":[345],"{Abstract":[346],"title}":[347],"[abstract].":[348],"In:":[349],"Proceedings":[350],"103rd":[353],"Annual":[354],"Meeting":[355],"American":[358],"Association":[359],"Cancer":[361,372],"Research;":[362],"2012":[363],"Mar":[364],"31-Apr":[365],"4;":[366],"Chicago,":[367],"IL.":[368],"Philadelphia":[369],"(PA):":[370],"AACR;":[371],"Res":[373],"2012;72(8":[374],"Suppl):Abstract":[375],"nr":[376],"3495.":[377],"doi:1538-7445.AM2012-3495":[378]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
