{"id":"https://openalex.org/W2013455102","doi":"https://doi.org/10.1073/pnas.032671499","title":"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens","display_name":"The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens","publication_year":2002,"publication_date":"2002-04-02","ids":{"openalex":"https://openalex.org/W2013455102","doi":"https://doi.org/10.1073/pnas.032671499","mag":"2013455102","pmid":"https://pubmed.ncbi.nlm.nih.gov/11930014","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/123701"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.032671499","doi":"https://doi.org/10.1073/pnas.032671499","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.032671499","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123701","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028768605","display_name":"Alexei I. Slesarev","orcid":"https://orcid.org/0000-0002-8672-7248","observed_orcids":["https://orcid.org/0000-0002-8672-7248"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Alexei I. Slesarev","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055936187","display_name":"Katja V. Mezhevaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Katja V. Mezhevaya","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020935277","display_name":"Kira S. Makarova","orcid":"https://orcid.org/0000-0002-8174-2844","observed_orcids":["https://orcid.org/0000-0002-8174-2844"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Kira S. Makarova","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058775185","display_name":"Nikolai N. Polushin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Nikolai N. Polushin","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060650232","display_name":"O. V. Shcherbinina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Olga V. Shcherbinina","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111653321","display_name":"Vera V. Shakhova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Vera V. Shakhova","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088565485","display_name":"Galina I. Belova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Galina I. Belova","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","Yale University, New Haven, CT,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]},{"raw_affiliation_string":"Yale University, New Haven, CT,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026932356","display_name":"L. Aravind","orcid":"https://orcid.org/0000-0003-0771-253X","observed_orcids":["https://orcid.org/0000-0003-0771-253X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"L. Aravind","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005555412","display_name":"Darren A. Natale","orcid":"https://orcid.org/0000-0001-5809-9523","observed_orcids":["https://orcid.org/0000-0001-5809-9523"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Darren A. Natale","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011845016","display_name":"Igor B. Rogozin","orcid":"https://orcid.org/0000-0003-0802-4851","observed_orcids":["https://orcid.org/0000-0003-0802-4851"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Igor B. Rogozin","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055758002","display_name":"Roman L. Tatusov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Roman L. Tatusov","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012792532","display_name":"Yuri I. Wolf","orcid":"https://orcid.org/0000-0002-0247-8708","observed_orcids":["https://orcid.org/0000-0002-0247-8708"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Yuri I. Wolf","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111961179","display_name":"Karl Otto STETTER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Karl O. Stetter","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077213236","display_name":"Andrei Malykh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Andrei G. Malykh","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035240489","display_name":"Eugene V. Koonin","orcid":"https://orcid.org/0000-0003-3943-8299","observed_orcids":["https://orcid.org/0000-0003-3943-8299"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Eugene V. Koonin","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025713241","display_name":"Sergei A. Kozyavkin","orcid":"https://orcid.org/0000-0001-5605-5113","observed_orcids":["https://orcid.org/0000-0001-5605-5113"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I4210127065","display_name":"Fidelity Systems (United States)","ror":"https://ror.org/033cp0g08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127065"]},{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE","RU","US"],"is_corresponding":false,"raw_author_name":"Sergei A. Kozyavkin","raw_affiliation_strings":["Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fidelity Systems, Gaithersburg, MD 20879: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210109390","https://openalex.org/I4210127065","https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.4211,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.99264035,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"99","issue":"7","first_page":"4644","last_page":"4649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10284","display_name":"Anaerobic Digestion and Biogas Production","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11791","display_name":"Microbial Community Ecology and Physiology","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methanopyrus-kandleri","display_name":"Methanopyrus kandleri","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperthermophilic-archaea","display_name":"hyperthermophilic archaea","score":0.828000009059906},{"id":"https://openalex.org/keywords/complete-genome-sequence","display_name":"complete genome sequence","score":0.8299999833106995},{"id":"https://openalex.org/keywords/monophyly","display_name":"monophyly","score":0.9890000224113464},{"id":"https://openalex.org/keywords/methanogenesis","display_name":"methanogenesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/genome-assembly","display_name":"genome assembly","score":0.46000000834465027},{"id":"https://openalex.org/keywords/protein-coding-genes","display_name":"protein-coding genes","score":0.609000027179718},{"id":"https://openalex.org/keywords/negatively-charged-amino-acids","display_name":"negatively charged amino acids","score":0.7580000162124634},{"id":"https://openalex.org/keywords/16s-rrna-phylogeny","display_name":"16S rRNA phylogeny","score":0.8370000123977661},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/methanocaldococcus-jannaschii","display_name":"Methanococcus jannaschii","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.958155632019043},{"id":"https://openalex.org/C2776878370","wikidata":"https://www.wikidata.org/wiki/Q2711364","display_name":"Methanococcus","level":4,"score":0.6633987426757812},{"id":"https://openalex.org/C2777438225","wikidata":"https://www.wikidata.org/wiki/Q1169785","display_name":"Methanogen","level":3,"score":0.660626232624054},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.6284486055374146},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5667031407356262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5660267472267151},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5445161461830139},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5352030396461487},{"id":"https://openalex.org/C12326286","wikidata":"https://www.wikidata.org/wiki/Q210958","display_name":"Monophyly","level":5,"score":0.502260684967041},{"id":"https://openalex.org/C2780148642","wikidata":"https://www.wikidata.org/wiki/Q4044130","display_name":"Methanomicrobiales","level":5,"score":0.43534934520721436},{"id":"https://openalex.org/C141036","wikidata":"https://www.wikidata.org/wiki/Q5158537","display_name":"Concerted evolution","level":4,"score":0.4347481429576874},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.4255558252334595},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17125234007835388},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.15094321966171265},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13379207253456116},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.09718367457389832},{"id":"https://openalex.org/C2778563749","wikidata":"https://www.wikidata.org/wiki/Q1942715","display_name":"Methanosarcina","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019605","descriptor_name":"Euryarchaeota","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D019605","descriptor_name":"Euryarchaeota","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019605","descriptor_name":"Euryarchaeota","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020745","descriptor_name":"Genome, Archaeal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.032671499","doi":"https://doi.org/10.1073/pnas.032671499","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.032671499","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:123701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:11930014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11930014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:73042","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0003-0771-253X>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:123701","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/123701","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G222768804","display_name":null,"funder_award_id":"DE\u2010FG02\u2010","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2677038581","display_name":"UniTool TM: Tools for Finishing of Eukaryotic Genomes","funder_award_id":"R43HG002186","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G7092767362","display_name":"THERMOFIDELASE FOR DNA SEQUENCING","funder_award_id":"R44GM055485","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1519987066","https://openalex.org/W1532568205","https://openalex.org/W1546864960","https://openalex.org/W1594492199","https://openalex.org/W1623642095","https://openalex.org/W1767251292","https://openalex.org/W1924311576","https://openalex.org/W1970273405","https://openalex.org/W1975061104","https://openalex.org/W1977922844","https://openalex.org/W1979558568","https://openalex.org/W1988676851","https://openalex.org/W1990453950","https://openalex.org/W1995557066","https://openalex.org/W2001279851","https://openalex.org/W2009154103","https://openalex.org/W2011213117","https://openalex.org/W2016000389","https://openalex.org/W2024819964","https://openalex.org/W2028199339","https://openalex.org/W2028590583","https://openalex.org/W2030416595","https://openalex.org/W2036847531","https://openalex.org/W2049504317","https://openalex.org/W2062754790","https://openalex.org/W2063538104","https://openalex.org/W2066724231","https://openalex.org/W2067853474","https://openalex.org/W2068070916","https://openalex.org/W2068689867","https://openalex.org/W2073321994","https://openalex.org/W2081108913","https://openalex.org/W2092911556","https://openalex.org/W2100005876","https://openalex.org/W2104454769","https://openalex.org/W2106090237","https://openalex.org/W2109030836","https://openalex.org/W2113679691","https://openalex.org/W2118515112","https://openalex.org/W2121166240","https://openalex.org/W2121367329","https://openalex.org/W2122642664","https://openalex.org/W2127596034","https://openalex.org/W2140526090","https://openalex.org/W2142529984","https://openalex.org/W2144362290","https://openalex.org/W2148622452","https://openalex.org/W2153123888","https://openalex.org/W2158350566","https://openalex.org/W2158714788","https://openalex.org/W2158757371","https://openalex.org/W2159482845","https://openalex.org/W2163285037","https://openalex.org/W2164075646","https://openalex.org/W3145257564","https://openalex.org/W4235069169","https://openalex.org/W4239632189","https://openalex.org/W4294216483","https://openalex.org/W6684235991","https://openalex.org/W7098838276","https://openalex.org/W7099585975"],"related_works":["https://openalex.org/W1872056168","https://openalex.org/W1999482530","https://openalex.org/W2062754790","https://openalex.org/W7097324721","https://openalex.org/W2126033097","https://openalex.org/W177875606","https://openalex.org/W4231425628","https://openalex.org/W156084217","https://openalex.org/W2122642664","https://openalex.org/W2030416595"],"abstract_inverted_index":{"We":[0],"have":[1,217],"determined":[2],"the":[3,8,32,55,106,128,131,166,200,231],"complete":[4],"1,694,969-nt":[5],"sequence":[6,69],"of":[7,11,28,35,68,95,113,130,146,168,196,202,209,234],"GC-rich":[9],"genome":[10,19,56,135],"Methanopyrus":[12],"kandleri":[13,37,88,119,156,164,198,214],"by":[14,44],"using":[15,143],"a":[16,66,122],"whole":[17],"direct":[18],"sequencing":[20,42],"approach.":[21],"This":[22],"approach":[23],"is":[24,199],"based":[25,151],"on":[26,152],"unlinking":[27],"genomic":[29],"DNA":[30],"with":[31,57,159,179],"ThermoFidelase":[33],"version":[34],"M.":[36,87,118,155,163,197,213],"topoisomerase":[38],"V":[39],"and":[40,72,79,149,182,207],"cycle":[41],"directed":[43],"2'-modified":[45],"oligonucleotides":[46],"(Fimers).":[47],"Sequencing":[48],"redundancy":[49],"(3.3x)":[50],"was":[51],"sufficient":[52],"to":[53,105,121,127,216],"assemble":[54],"less":[58],"than":[59,224],"one":[60],"error":[61],"per":[62],"40":[63],"kb.":[64],"Using":[65],"combination":[67],"database":[70],"searches":[71],"coding":[73],"potential":[74],"prediction,":[75],"1,692":[76],"protein-coding":[77],"genes":[78,81,169,219],"39":[80],"for":[82],"structural":[83],"RNAs":[84],"were":[85],"identified.":[86],"proteins":[89,148,203],"show":[90],"an":[91,103],"unusually":[92],"high":[93,107],"content":[94],"negatively":[96],"charged":[97],"amino":[98],"acids,":[99],"which":[100],"might":[101,229],"be":[102],"adaptation":[104],"intracellular":[108],"salinity.":[109],"Previous":[110],"phylogenetic":[111],"analysis":[112],"16S":[114],"RNA":[115],"suggested":[116],"that":[117,188],"belonged":[120],"very":[123],"deep":[124],"branch,":[125],"close":[126],"root":[129],"archaeal":[132,161,189],"tree.":[133],"However,":[134],"comparisons":[136],"indicate":[137,187],"that,":[138],"in":[139,171,174,205],"both":[140],"trees":[141,150],"constructed":[142],"concatenated":[144],"alignments":[145],"ribosomal":[147],"gene":[153,210],"content,":[154],"consistently":[157],"groups":[158],"other":[160,225],"methanogens.":[162],"shares":[165],"set":[167],"implicated":[170],"methanogenesis":[172],"and,":[173],"part,":[175],"its":[176],"operon":[177],"organization":[178],"Methanococcus":[180],"jannaschii":[181],"Methanothermobacter":[183],"thermoautotrophicum.":[184],"These":[185,227],"findings":[186],"methanogens":[190],"are":[191],"monophyletic.":[192],"A":[193],"distinctive":[194],"feature":[195],"paucity":[201],"involved":[204],"signaling":[206],"regulation":[208],"expression.":[211],"Also,":[212],"appears":[215],"fewer":[218],"acquired":[220],"via":[221],"lateral":[222],"transfer":[223],"archaea.":[226],"features":[228],"reflect":[230],"extreme":[232],"habitat":[233],"this":[235],"organism.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
