{"id":"https://openalex.org/W2013454062","doi":"https://doi.org/10.1186/1741-7015-4-16","title":"Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study","display_name":"Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study","publication_year":2006,"publication_date":"2006-06-30","ids":{"openalex":"https://openalex.org/W2013454062","doi":"https://doi.org/10.1186/1741-7015-4-16","mag":"2013454062","pmid":"https://pubmed.ncbi.nlm.nih.gov/16813654","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1555602"},"language":"en","primary_location":{"id":"doi:10.1186/1741-7015-4-16","doi":"https://doi.org/10.1186/1741-7015-4-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-4-16","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-4-16","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-4-16","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Per.Hall@ki.se","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Per.Hall@ki.se","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010427465","display_name":"Alexander Ploner","orcid":"https://orcid.org/0000-0002-5042-8326","observed_orcids":["https://orcid.org/0000-0002-5042-8326"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Alexander Ploner","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076773519","display_name":"Judith Bj\u00f6hle","orcid":"https://orcid.org/0000-0002-1902-4032","observed_orcids":["https://orcid.org/0000-0002-1902-4032"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Judith Bj\u00f6hle","raw_affiliation_strings":["Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050756282","display_name":"Fei Huang","orcid":"https://orcid.org/0000-0001-9769-4798","observed_orcids":["https://orcid.org/0000-0001-9769-4798"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Huang","raw_affiliation_strings":["Bristol-Myers Squibb, Princeton, NJ, USA","Bristol Myers Squibb, Princeton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Bristol Myers Squibb, Princeton, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028835404","display_name":"Chin\u2010Yo Lin","orcid":"https://orcid.org/0000-0002-4461-6216","observed_orcids":["https://orcid.org/0000-0002-4461-6216"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chin-Yo Lin","raw_affiliation_strings":["Genome Institute of Singapore, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Republic of Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005961131","display_name":"Edison T. Liu","orcid":"https://orcid.org/0000-0003-4293-4795","observed_orcids":["https://orcid.org/0000-0003-4293-4795"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Edison T Liu","raw_affiliation_strings":["Genome Institute of Singapore, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Republic of Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024804165","display_name":"Lance David Miller","orcid":"https://orcid.org/0000-0003-3799-2528","observed_orcids":["https://orcid.org/0000-0003-3799-2528"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lance D Miller","raw_affiliation_strings":["Genome Institute of Singapore, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Institute of Singapore, Republic of Singapore","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089186426","display_name":"Hans Nordgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hans Nordgren","raw_affiliation_strings":["Department of Pathology, Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012606625","display_name":"Yudi Pawitan Y","orcid":"https://orcid.org/0000-0003-0324-7052","observed_orcids":["https://orcid.org/0000-0003-0324-7052"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yudi Pawitan","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038781104","display_name":"Peter Martin Shaw","orcid":"https://orcid.org/0000-0002-3187-8938","observed_orcids":["https://orcid.org/0000-0002-3187-8938"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Shaw","raw_affiliation_strings":["Bristol-Myers Squibb, Princeton, NJ, USA","Bristol Myers Squibb, Princeton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Squibb, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Bristol Myers Squibb, Princeton, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026065105","display_name":"Lambert K. Skoog","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lambert Skoog","raw_affiliation_strings":["Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073780919","display_name":"Johanna Smeds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johanna Smeds","raw_affiliation_strings":["Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035897444","display_name":"Sara Wedr\u00e9n","orcid":"https://orcid.org/0000-0002-2436-1519","observed_orcids":["https://orcid.org/0000-0002-2436-1519"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sara Wedr\u00e9n","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N#        Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034716213","display_name":"John \u00d6hd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"John \u00d6hd","raw_affiliation_strings":["Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071571360","display_name":"Jonas C. S. Bergh","orcid":"https://orcid.org/0000-0001-5526-1847","observed_orcids":["https://orcid.org/0000-0001-5526-1847"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Bergh","raw_affiliation_strings":["Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet and Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010427465"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.7098,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.84928395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormone-replacement-therapy","display_name":"hormone replacement therapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.8410000205039978},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-tumors","display_name":"estrogen receptor-positive tumors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.7400000095367432},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.8769999742507935},{"id":"https://openalex.org/keywords/estrogen-exposure","display_name":"estrogen exposure","score":0.6430000066757202},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9685062766075134},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.688980758190155},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6173831224441528},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.5587236881256104},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5438708066940308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5406979322433472},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5135555267333984},{"id":"https://openalex.org/C2780275930","wikidata":"https://www.wikidata.org/wiki/Q1628266","display_name":"Hormone therapy","level":4,"score":0.4765784740447998},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4634634554386139},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4323952794075012},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42930343747138977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3927347958087921},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32928892970085144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10797417163848877},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.07456231117248535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015914","descriptor_name":"Estrogen Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1741-7015-4-16","doi":"https://doi.org/10.1186/1741-7015-4-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-4-16","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-4-16","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:350953","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1555602","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16813654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16813654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.276.9765","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.276.9765","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ad/30/BMC_Med_2006_Jun_30_4_16.tar.gz","raw_type":"text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/143467","doi":null,"is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/143467","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4d83b06dad5b4768b08c649baa4844a0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4d83b06dad5b4768b08c649baa4844a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 4, Iss 1, p 16 (2006)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1741-7015-4-16","doi":"https://doi.org/10.1186/1741-7015-4-16","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-4-16","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-4-16","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013454062.pdf","grobid_xml":"https://content.openalex.org/works/W2013454062.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1551632868","https://openalex.org/W1586699954","https://openalex.org/W1696506515","https://openalex.org/W1843666312","https://openalex.org/W1891851065","https://openalex.org/W1972393754","https://openalex.org/W1975264727","https://openalex.org/W1978918505","https://openalex.org/W1987184026","https://openalex.org/W1987556047","https://openalex.org/W1995502007","https://openalex.org/W1999463736","https://openalex.org/W2002842589","https://openalex.org/W2004693593","https://openalex.org/W2007461054","https://openalex.org/W2008233728","https://openalex.org/W2021383412","https://openalex.org/W2040578975","https://openalex.org/W2044702943","https://openalex.org/W2052807291","https://openalex.org/W2062615522","https://openalex.org/W2070418652","https://openalex.org/W2074089196","https://openalex.org/W2077529129","https://openalex.org/W2084597093","https://openalex.org/W2087331538","https://openalex.org/W2096079397","https://openalex.org/W2097255042","https://openalex.org/W2097431354","https://openalex.org/W2109388713","https://openalex.org/W2112311270","https://openalex.org/W2116665077","https://openalex.org/W2121071871","https://openalex.org/W2121350574","https://openalex.org/W2128985829","https://openalex.org/W2129353515","https://openalex.org/W2131994307","https://openalex.org/W2140276460","https://openalex.org/W2141127028","https://openalex.org/W2141647078","https://openalex.org/W2144701098","https://openalex.org/W2164399860","https://openalex.org/W2166376600","https://openalex.org/W2169612030","https://openalex.org/W2181607092","https://openalex.org/W2259802687","https://openalex.org/W2289353246","https://openalex.org/W2346841190","https://openalex.org/W2415761543","https://openalex.org/W2469416225","https://openalex.org/W2515721699","https://openalex.org/W3140406626","https://openalex.org/W4241276954"],"related_works":["https://openalex.org/W1968804342","https://openalex.org/W7100494557","https://openalex.org/W1803973308","https://openalex.org/W2077529129","https://openalex.org/W2157116046","https://openalex.org/W1987184026","https://openalex.org/W3093601628","https://openalex.org/W2121740447","https://openalex.org/W7155208211","https://openalex.org/W2266397914"],"abstract_inverted_index":{"BACKGROUND:":[0],"Postmenopausal":[1],"hormone-replacement":[2],"therapy":[3],"(HRT)":[4],"increases":[5],"breast-cancer":[6,27],"risk.":[7],"The":[8],"influence":[9],"of":[10,15,75,92,141,178],"HRT":[11,55,97,123,149],"on":[12,81,181],"the":[13,16,39,139,176],"biology":[14],"primary":[17],"tumor,":[18],"however,":[19],"is":[20,151],"not":[21],"well":[22],"understood.":[23],"METHODS:":[24],"We":[25,37],"obtained":[26],"gene":[28,43,117,128,156,171],"expression":[29,157,172],"profiles":[30,79],"using":[31],"Affymetrix":[32],"human":[33],"genome":[34],"U133A":[35],"arrays.":[36],"examined":[38],"relationship":[40],"between":[41],"HRT-regulated":[42],"profiles,":[44],"tumor":[45],"characteristics,":[46],"and":[47,99,164],"recurrence-free":[48,162],"survival":[49,105,163],"in":[50,57,119,173],"72":[51],"postmenopausal":[52],"women.":[53],"RESULTS:":[54],"use":[56,98,150],"patients":[58],"with":[59,71,96,112,122,127,138,153],"estrogen":[60,133],"receptor":[61],"(ER)":[62],"protein":[63,167],"positive":[64],"tumors":[65,86,120,174],"(n":[66],"=":[67],"72)":[68],"was":[69,94,124],"associated":[70,95,121,152],"an":[72],"altered":[73],"regulation":[74,118,129],"276":[76],"genes.":[77],"Expression":[78],"based":[80],"these":[82],"genes":[83],"clustered":[84],"ER-positive":[85],"into":[87],"two":[88],"molecular":[89],"subclasses,":[90],"one":[91],"which":[93],"had":[100],"significantly":[101],"better":[102,161],"recurrence":[103],"free":[104],"despite":[106],"lower":[107,165],"ER":[108,166],"levels.":[109,168],"A":[110],"comparison":[111],"external":[113],"data":[114],"suggested":[115],"that":[116,147],"negatively":[125],"correlated":[126,137],"induced":[130],"by":[131],"short-term":[132],"exposure,":[134],"but":[135],"positively":[136],"effect":[140,177],"tamoxifen.":[142],"CONCLUSION:":[143],"Our":[144],"findings":[145],"suggest":[146],"post-menopausal":[148],"a":[154],"distinct":[155],"profile":[158],"related":[159],"to":[160],"Tentatively,":[169],"HRT-associated":[170],"resembles":[175],"tamoxifen":[179],"exposure":[180],"MCF-7":[182],"cells.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}