{"id":"https://openalex.org/W2013453542","doi":"https://doi.org/10.1038/sj.bjc.6602162","title":"Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer","display_name":"Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer","publication_year":2004,"publication_date":"2004-09-14","ids":{"openalex":"https://openalex.org/W2013453542","doi":"https://doi.org/10.1038/sj.bjc.6602162","mag":"2013453542","pmid":"https://pubmed.ncbi.nlm.nih.gov/15365568","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2409926"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6602162","doi":"https://doi.org/10.1038/sj.bjc.6602162","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602162","pdf_url":"https://www.nature.com/articles/6602162.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6602162.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056471340","display_name":"Stephen Y.T. Chan","orcid":"https://orcid.org/0000-0001-8865-6618","observed_orcids":["https://orcid.org/0000-0001-8865-6618","https://orcid.org/0000-0001-8998-5480"]},"institutions":[{"id":"https://openalex.org/I2802921333","display_name":"Nottingham City Hospital","ror":"https://ror.org/0022b3c04","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I2802921333"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S Chan","raw_affiliation_strings":["The City Hospital, Nottingham NG5 1PB, UK. schan2@ncht.trent.nhs.uk","The City Hospital, Nottingham NG5 1PB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The City Hospital, Nottingham NG5 1PB, UK. schan2@ncht.trent.nhs.uk","institution_ids":["https://openalex.org/I2802921333"]},{"raw_affiliation_string":"The City Hospital, Nottingham NG5 1PB, UK","institution_ids":["https://openalex.org/I2802921333"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056471340"],"corresponding_institution_ids":["https://openalex.org/I2802921333"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.3733,"has_fulltext":true,"cited_by_count":303,"citation_normalized_percentile":{"value":0.91171834,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"91","issue":"8","first_page":"1420","last_page":"1424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9559999704360962},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.843999981880188},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.847000002861023},{"id":"https://openalex.org/keywords/g1-phase","display_name":"G1 phase","score":0.7039999961853027},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/rapamycin-analogues","display_name":"rapamycin analogs","score":0.7609999775886536},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.9362524747848511},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6403136849403381},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5513383150100708},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.54405677318573},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.5297247767448425},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.5151202082633972},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5066588521003723},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4674338400363922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.459504097700119},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4542241394519806},{"id":"https://openalex.org/C2909831755","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Proto-Oncogene Proteins c-akt","level":4,"score":0.44813403487205505},{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.4239882826805115},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.42248159646987915},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4192489981651306},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.40262308716773987},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3771452009677887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3746787905693054},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30995696783065796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17628419399261475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06592008471488953},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6602162","doi":"https://doi.org/10.1038/sj.bjc.6602162","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602162","pdf_url":"https://www.nature.com/articles/6602162.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:15365568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15365568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2409926","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2409926/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6602162","doi":"https://doi.org/10.1038/sj.bjc.6602162","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6602162","pdf_url":"https://www.nature.com/articles/6602162.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013453542.pdf","grobid_xml":"https://content.openalex.org/works/W2013453542.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1486193010","https://openalex.org/W1523162832","https://openalex.org/W1524986936","https://openalex.org/W1661647511","https://openalex.org/W1986873843","https://openalex.org/W1993836723","https://openalex.org/W1997006452","https://openalex.org/W2003347015","https://openalex.org/W2057106513","https://openalex.org/W2059956556","https://openalex.org/W2068413127","https://openalex.org/W2084147994","https://openalex.org/W2093571366","https://openalex.org/W2103002807","https://openalex.org/W2114492564","https://openalex.org/W2124221273","https://openalex.org/W2126493366","https://openalex.org/W2130773839","https://openalex.org/W2142506125","https://openalex.org/W2146697101","https://openalex.org/W2148842373","https://openalex.org/W2155865481","https://openalex.org/W2257439960","https://openalex.org/W2275499694","https://openalex.org/W2336058699","https://openalex.org/W3022312776","https://openalex.org/W4230340075"],"related_works":["https://openalex.org/W2411332552","https://openalex.org/W1977943009","https://openalex.org/W2054428956","https://openalex.org/W2089668045","https://openalex.org/W2151576707","https://openalex.org/W1981625093","https://openalex.org/W2018022997","https://openalex.org/W1858396592","https://openalex.org/W2110604215","https://openalex.org/W1210193786"],"abstract_inverted_index":{"mTOR":[0,112],"is":[1,117],"a":[2,12,71,83],"downstream":[3,51],"mediator":[4],"in":[5,15,56,61,73,101],"the":[6,41,50,57,62,76,89,97,108],"PI3K/Akt":[7],"signalling":[8,52],"pathway,":[9],"which":[10,80],"plays":[11],"critical":[13],"role":[14],"regulating":[16],"basic":[17,94],"cellular":[18],"functions.":[19],"These":[20],"include":[21],"cell":[22,58],"proliferation,":[23],"survival,":[24],"mobility":[25],"and":[26,29,34,54,123],"angiogenesis.":[27],"Rapamycin":[28],"its":[30],"analogues":[31],"(CCI-779,":[32],"RAD001":[33],"AP23573)":[35],"have":[36,70],"specific":[37],"antagonistic":[38],"action":[39],"on":[40],"function":[42],"of":[43,49,67,78,85,88,96,107],"mTOR.":[44],"This":[45,65,116],"leads":[46],"to":[47,127],"inhibition":[48],"elements":[53],"results":[55,106],"cycle":[59],"arrest":[60],"G1":[63],"phase.":[64],"group":[66],"drugs":[68],"may":[69],"place":[72],"Oncology":[74],"for":[75,113,121],"treatment":[77],"cancers,":[79],"occur":[81],"as":[82],"result":[84],"increased":[86],"activity":[87],"PI3":[90],"kinase/Akt/m-TOR":[91],"pathway.":[92],"The":[93],"structure":[95],"pathway":[98],"was":[99],"reviewed":[100],"this":[102],"article,":[103],"together":[104],"with":[105],"clinical":[109],"studies":[110],"targeting":[111],"cancer":[114],"therapy.":[115],"an":[118],"exciting":[119],"area":[120],"development":[122],"poses":[124],"many":[125],"challenges":[126],"researchers.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
