{"id":"https://openalex.org/W2013439787","doi":"https://doi.org/10.1007/pl00005351","title":"Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine","display_name":"Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine","publication_year":1999,"publication_date":"1999-04-21","ids":{"openalex":"https://openalex.org/W2013439787","doi":"https://doi.org/10.1007/pl00005351","mag":"2013439787","pmid":"https://pubmed.ncbi.nlm.nih.gov/10344524"},"language":"en","primary_location":{"id":"doi:10.1007/pl00005351","doi":"https://doi.org/10.1007/pl00005351","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00005351","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111653286","display_name":"Christina Bock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Bock","raw_affiliation_strings":["Pharmakologisches Institut der Alber-Ludwigs-Universit\u00e4t, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmakologisches Institut der Alber-Ludwigs-Universit\u00e4t, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018127505","display_name":"Nathalie Niederhoffer","orcid":"https://orcid.org/0000-0003-4075-3675","observed_orcids":["https://orcid.org/0000-0003-4075-3675"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nathalie Niederhoffer","raw_affiliation_strings":["Pharmakologisches Institut der Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Strasse 5, D-79104 Freiburg i.Br., Germany e-mail: szabo@ruf.uni-freiburg.de, Fax: +49-761-2035318, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmakologisches Institut der Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Strasse 5, D-79104 Freiburg i.Br., Germany e-mail: szabo@ruf.uni-freiburg.de, Fax: +49-761-2035318, DE","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019565160","display_name":"B. Szab\u00f3","orcid":"https://orcid.org/0000-0002-0097-9867","observed_orcids":["https://orcid.org/0000-0002-0097-9867"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Szabo","raw_affiliation_strings":["Pharmakologisches Institut der Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Strasse 5, D-79104 Freiburg i.Br., Germany e-mail: szabo@ruf.uni-freiburg.de, Fax: +49-761-2035318, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmakologisches Institut der Albert-Ludwigs-Universit\u00e4t, Hermann-Herder-Strasse 5, D-79104 Freiburg i.Br., Germany e-mail: szabo@ruf.uni-freiburg.de, Fax: +49-761-2035318, DE","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.7661,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.6571931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"359","issue":"4","first_page":"262","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.13109999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rilmenidine","display_name":"rilmenidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/moxonidine","display_name":"moxonidine","score":1.0},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.906000018119812},{"id":"https://openalex.org/keywords/i1-imidazoline-receptor","display_name":"imidazoline I1 receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/methyldopa","display_name":"methyldopa","score":0.8029999732971191},{"id":"https://openalex.org/keywords/efaroxan","display_name":"efaroxan","score":0.9710000157356262},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.859000027179718},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7329999804496765},{"id":"https://openalex.org/keywords/plasma-norepinephrine","display_name":"plasma norepinephrine","score":0.996999979019165},{"id":"https://openalex.org/keywords/receptor-antagonism","display_name":"receptor antagonism","score":0.6470000147819519},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2777014715","wikidata":"https://www.wikidata.org/wiki/Q419944","display_name":"Moxonidine","level":4,"score":0.9811346530914307},{"id":"https://openalex.org/C2780307058","wikidata":"https://www.wikidata.org/wiki/Q967973","display_name":"Rilmenidine","level":4,"score":0.9097409844398499},{"id":"https://openalex.org/C123605464","wikidata":"https://www.wikidata.org/wiki/Q1659850","display_name":"Imidazoline receptor","level":2,"score":0.8915070295333862},{"id":"https://openalex.org/C2777676773","wikidata":"https://www.wikidata.org/wiki/Q412226","display_name":"Yohimbine","level":4,"score":0.8396459221839905},{"id":"https://openalex.org/C2780815205","wikidata":"https://www.wikidata.org/wiki/Q5613599","display_name":"Guanfacine","level":3,"score":0.6632304787635803},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.6481338739395142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6305891275405884},{"id":"https://openalex.org/C13348194","wikidata":"https://www.wikidata.org/wiki/Q288084","display_name":"Alpha-2 adrenergic receptor","level":3,"score":0.5380866527557373},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5188804268836975},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.47498053312301636},{"id":"https://openalex.org/C2776289377","wikidata":"https://www.wikidata.org/wiki/Q412621","display_name":"Methyldopa","level":3,"score":0.4569634795188904},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37011024355888367},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.36693525314331055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2658238708972931},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.19216865301132202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18378376960754395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06791526079177856}],"mesh":[{"descriptor_ui":"D000077769","descriptor_name":"Rilmenidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000317","descriptor_name":"Adrenergic alpha-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001552","descriptor_name":"Benzazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008750","descriptor_name":"Methyldopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015016","descriptor_name":"Yohimbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054755","descriptor_name":"Imidazoline Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/pl00005351","doi":"https://doi.org/10.1007/pl00005351","is_oa":false,"landing_page_url":"https://doi.org/10.1007/pl00005351","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:10344524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10344524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:freidok.uni-freiburg.de:36879","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/36879","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology. - 359, 4 (1999) , 262-271, ISSN: 0028-1298","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W11560389","https://openalex.org/W206420209","https://openalex.org/W1839110460","https://openalex.org/W1952790402","https://openalex.org/W1964818296","https://openalex.org/W1977754608","https://openalex.org/W1986146943","https://openalex.org/W1988230646","https://openalex.org/W1998680340","https://openalex.org/W1999634188","https://openalex.org/W2001569974","https://openalex.org/W2010675391","https://openalex.org/W2014321807","https://openalex.org/W2019938938","https://openalex.org/W2023775324","https://openalex.org/W2027461964","https://openalex.org/W2028513805","https://openalex.org/W2028826814","https://openalex.org/W2034017721","https://openalex.org/W2041487560","https://openalex.org/W2043425461","https://openalex.org/W2051022964","https://openalex.org/W2058206922","https://openalex.org/W2059365926","https://openalex.org/W2067076857","https://openalex.org/W2069014013","https://openalex.org/W2070396511","https://openalex.org/W2073106478","https://openalex.org/W2073578428","https://openalex.org/W2080202671","https://openalex.org/W2085749968","https://openalex.org/W2091719591","https://openalex.org/W2098810848","https://openalex.org/W2106640536","https://openalex.org/W2164014399","https://openalex.org/W2229032023","https://openalex.org/W2263011601","https://openalex.org/W2274821401","https://openalex.org/W2278262600","https://openalex.org/W2318073724","https://openalex.org/W2411152795","https://openalex.org/W2463215628","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2106640536","https://openalex.org/W2004271229","https://openalex.org/W2043143883","https://openalex.org/W1964811646","https://openalex.org/W2415285515","https://openalex.org/W2079689837","https://openalex.org/W2322676654","https://openalex.org/W2089706913","https://openalex.org/W2063504587","https://openalex.org/W1977982838"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}