{"id":"https://openalex.org/W2013426756","doi":"https://doi.org/10.1113/jphysiol.1966.sp007953","title":"Nerve implants in botulinum poisoned mammalian muscle","display_name":"Nerve implants in botulinum poisoned mammalian muscle","publication_year":1966,"publication_date":"1966-06-01","ids":{"openalex":"https://openalex.org/W2013426756","doi":"https://doi.org/10.1113/jphysiol.1966.sp007953","mag":"2013426756","pmid":"https://pubmed.ncbi.nlm.nih.gov/4223682","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1357623"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1966.sp007953","doi":"https://doi.org/10.1113/jphysiol.1966.sp007953","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1966.sp007953","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1357623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109161225","display_name":"S\u00f6ren Fex","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Fex","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109157318","display_name":"\u0392. Sonesson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Sonesson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043528180","display_name":"S. Thesleff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Thesleff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113681458","display_name":"Ji\u0159ina Zelen\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jirina Zelen\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":7.1917,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.96709753,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"184","issue":"4","first_page":"872","last_page":"882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.10809999704360962,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin","display_name":"botulinum toxin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.7269999980926514},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.46299999952316284},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.8830000162124634},{"id":"https://openalex.org/keywords/end-plate-potential","display_name":"end-plate potential","score":0.6729999780654907},{"id":"https://openalex.org/keywords/neuromuscular-electrical-stimulation","display_name":"neuromuscular electrical stimulation","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6695055961608887},{"id":"https://openalex.org/C2777240379","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Neuromuscular junction","level":2,"score":0.6603024005889893},{"id":"https://openalex.org/C2775912687","wikidata":"https://www.wikidata.org/wiki/Q2422765","display_name":"Motor nerve","level":2,"score":0.6112074851989746},{"id":"https://openalex.org/C2909770972","wikidata":"https://www.wikidata.org/wiki/Q776995","display_name":"Motor Endplate","level":3,"score":0.606151282787323},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.596650242805481},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5925052165985107},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.5910007357597351},{"id":"https://openalex.org/C2781197403","wikidata":"https://www.wikidata.org/wiki/Q193472","display_name":"Trunk","level":2,"score":0.4712534248828888},{"id":"https://openalex.org/C3017897630","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Muscle fibre","level":3,"score":0.45641428232192993},{"id":"https://openalex.org/C136357698","wikidata":"https://www.wikidata.org/wiki/Q3290037","display_name":"Free nerve ending","level":2,"score":0.41724133491516113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39120060205459595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3425953984260559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27866360545158386},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1794530153274536},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.145903080701828},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.14004871249198914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10260647535324097},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001906","descriptor_name":"Botulism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003714","descriptor_name":"Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009470","descriptor_name":"Muscle Spindles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1966.sp007953","doi":"https://doi.org/10.1113/jphysiol.1966.sp007953","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1966.sp007953","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1357623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1357623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:4223682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4223682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1357623","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1357623","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1793046221","https://openalex.org/W1969954956","https://openalex.org/W1973188060","https://openalex.org/W1978230512","https://openalex.org/W1989119181","https://openalex.org/W1989847392","https://openalex.org/W2015708185","https://openalex.org/W2018555602","https://openalex.org/W2062478860","https://openalex.org/W2068859520","https://openalex.org/W2074776682","https://openalex.org/W2076081049","https://openalex.org/W2114047176","https://openalex.org/W2142303954","https://openalex.org/W2416070615","https://openalex.org/W2431015743","https://openalex.org/W4214698450","https://openalex.org/W4365787136","https://openalex.org/W4388507765"],"related_works":["https://openalex.org/W2080197611","https://openalex.org/W1978913602","https://openalex.org/W2406784926","https://openalex.org/W1545330573","https://openalex.org/W2320828358","https://openalex.org/W1971316239","https://openalex.org/W2333285148","https://openalex.org/W2061447195","https://openalex.org/W2098776203","https://openalex.org/W7024407565"],"abstract_inverted_index":{"1.":[0],"In":[1,63,78],"albino":[2],"rats":[3],"the":[4,50,56,79,91,95,102,112,115,124,128,145,157],"botulinum":[5,64,106],"poisoned":[6],"gastrocnemius":[7,125],"muscle":[8,21,146,167],"was":[9,169],"supplied":[10],"with":[11,23,148],"an":[12],"accessory":[13],"motor":[14,117],"nerve":[15,48,97,118],"in":[16,40,90,123,165,171],"order":[17],"to":[18,44],"investigate":[19],"whether":[20],"fibres":[22,147,178],"structurally":[24],"intact":[25,154],"but":[26],"non-transmitting":[27],"synapses":[28],"would":[29],"accept":[30],"additional":[31],"innervation.":[32],"As":[33],"a":[34,59,83,166,172],"control":[35,80],"similar":[36],"operations":[37],"were":[38,52,76,88,130],"made":[39],"unpoisoned":[41],"rats.2.":[42],"One":[43],"three":[45],"months":[46],"after":[47],"implantation":[49],"muscles":[51,66],"examined":[53],"histologically":[54],"for":[55],"presence":[57,161],"of":[58,73,94,105,110,137,144,162,182,187],"new":[60,74,149],"end-plate":[61,183],"zone.":[62],"treated":[65],"1662":[67],"+/-":[68,71,86],"165":[69],"(mean":[70],"S.D.)":[72],"end-plates":[75,150,164],"found.":[77],"animals":[81],"only":[82],"few":[84,173],"(90":[85],"13)":[87],"observed":[89],"immediate":[92],"vicinity":[93],"implanted":[96,113],"trunk.3.":[98],"Following":[99],"recovery":[100],"from":[101,156],"paralysing":[103],"action":[104],"toxin":[107],"electrical":[108],"stimulation":[109,186],"both":[111],"and":[114],"original":[116,158],"evoked":[119],"strong":[120],"mechanical":[121],"twitches":[122],"muscle.4.":[126],"When":[127],"nerves":[129],"stimulated":[131],"simultaneously":[132],"little":[133],"or":[134],"no":[135],"summation":[136],"tension":[138],"occurred,":[139],"indicating":[140],"that":[141],"presumably":[142],"many":[143],"also":[151],"had":[152],"functionally":[153],"junctions":[155],"nerve.":[159,189],"The":[160],"two":[163],"fibre":[168],"confirmed":[170],"experiments":[174],"on":[175,185],"single":[176],"curarized":[177],"by":[179],"intracellular":[180],"recording":[181],"potentials":[184],"each":[188]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}