{"id":"https://openalex.org/W20134117","doi":null,"title":"HIV transmission and primary drug resistance.","display_name":"HIV transmission and primary drug resistance.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W20134117","mag":"20134117","pmid":"https://pubmed.ncbi.nlm.nih.gov/16736948"},"language":"en","primary_location":{"id":"pmid:16736948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16736948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dan Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dan Turner","raw_affiliation_strings":["AIDS Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AIDS Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A Wainberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.9988,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95348221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"17","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-transmission","display_name":"HIV transmission","score":0.9829999804496765},{"id":"https://openalex.org/keywords/primary-drug-resistance","display_name":"primary drug resistance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/multidrug-resistant-hiv","display_name":"multidrug-resistant HIV","score":0.9300000071525574},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.7260000109672546},{"id":"https://openalex.org/keywords/viral-replication-fitness","display_name":"viral replication fitness","score":0.8619999885559082},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.8579999804496765},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.7812129259109497},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5724557638168335},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5630110502243042},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.547274112701416},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48522117733955383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4327438175678253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42242902517318726},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41592830419540405},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.37533122301101685},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.36614543199539185},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2999526262283325},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2953551709651947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1830567717552185},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.12267428636550903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08157461881637573},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D024921","descriptor_name":"Drug Resistance, Multiple, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16736948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16736948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS reviews","raw_type":"Journal Article"},{"id":"mag:20134117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16736948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W32826563","https://openalex.org/W170849090","https://openalex.org/W1485875137","https://openalex.org/W1964508839","https://openalex.org/W1967326599","https://openalex.org/W1970588125","https://openalex.org/W1972548566","https://openalex.org/W1989014098","https://openalex.org/W1989632025","https://openalex.org/W1995626592","https://openalex.org/W1998581885","https://openalex.org/W2002945974","https://openalex.org/W2020329700","https://openalex.org/W2021903049","https://openalex.org/W2025528546","https://openalex.org/W2027567211","https://openalex.org/W2042888637","https://openalex.org/W2048277541","https://openalex.org/W2054689747","https://openalex.org/W2056884098","https://openalex.org/W2060499390","https://openalex.org/W2063652605","https://openalex.org/W2078929483","https://openalex.org/W2079139407","https://openalex.org/W2080196370","https://openalex.org/W2083430366","https://openalex.org/W2086783015","https://openalex.org/W2091013562","https://openalex.org/W2103428845","https://openalex.org/W2108875285","https://openalex.org/W2110249458","https://openalex.org/W2135091977","https://openalex.org/W2138106725","https://openalex.org/W2141149454","https://openalex.org/W2145107025","https://openalex.org/W2148693026","https://openalex.org/W2148711016","https://openalex.org/W2152021373","https://openalex.org/W2155180251","https://openalex.org/W2158134782","https://openalex.org/W2159362579","https://openalex.org/W2169426527","https://openalex.org/W2169916808","https://openalex.org/W2406258632","https://openalex.org/W2615170291","https://openalex.org/W4234790260"],"related_works":["https://openalex.org/W2414081632","https://openalex.org/W2274470182","https://openalex.org/W2001544917","https://openalex.org/W2407191543","https://openalex.org/W2130978768","https://openalex.org/W2059529130","https://openalex.org/W7099925179","https://openalex.org/W2158451638","https://openalex.org/W2410658852","https://openalex.org/W2157625591"],"abstract_inverted_index":{"Transmission":[0],"of":[1,28,46,48,57,60,74,81,84,106,128,138,147],"HIV":[2,85,113],"viruses":[3,62],"harboring":[4],"resistance":[5,94],"mutations":[6,50],"is":[7,71],"already":[8],"a":[9,132],"major":[10],"concern":[11,70],"in":[12,86,141],"developed":[13],"countries,":[14],"with":[15,76],"the":[16,26,58,65,72,79,108,136,142,145],"potential":[17],"to":[18,53,95,122],"impact":[19,134],"on":[20,135],"therapeutic":[21,54,104],"strategies.":[22,55],"Several":[23],"factors":[24],"influence":[25],"transmission":[27,36,47,59,83,146],"such":[29],"viruses,":[30],"including":[31],"viral":[32,149],"replication":[33],"fitness":[34],"and":[35,100,110,144],"fitness,":[37],"although":[38],"behavioral":[39],"characteristics":[40],"must":[41],"also":[42],"be":[43],"considered.":[44],"Rates":[45],"specific":[49],"are":[51],"related":[52],"Reports":[56],"multidrug-resistant":[61],"should":[63],"alarm":[64],"medical":[66],"community.":[67],"An":[68],"additional":[69],"use":[73],"monotherapy":[75],"nevirapine":[77],"for":[78,93],"prevention":[80],"mother-to-child":[82],"developing":[87],"countries":[88],"as":[89],"this":[90],"practice":[91],"selects":[92],"nonnucleoside":[96],"reverse":[97],"transcription":[98],"inhibitors":[99],"could":[101],"limit":[102],"future":[103],"options":[105],"both":[107],"mothers":[109],"infected":[111],"children.":[112],"treatment":[114],"guidelines":[115],"have":[116],"evolved,":[117],"shifting":[118],"from":[119],"more":[120,123],"aggressive":[121],"conservative":[124],"approaches.":[125],"This":[126],"change":[127],"strategy":[129],"has":[130],"had":[131],"direct":[133],"prevalence":[137],"drug-resistant":[139],"virus":[140],"population":[143],"resistant":[148],"species.":[150]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}