{"id":"https://openalex.org/W2013404121","doi":"https://doi.org/10.1530/jrf.0.1000439","title":"Influence of epidermal growth factor and transforming growth factor-\u03b1 on in vitro maturation of cumulus cell-enclosed bovine oocytes in a defined medium","display_name":"Influence of epidermal growth factor and transforming growth factor-\u03b1 on in vitro maturation of cumulus cell-enclosed bovine oocytes in a defined medium","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W2013404121","doi":"https://doi.org/10.1530/jrf.0.1000439","mag":"2013404121","pmid":"https://pubmed.ncbi.nlm.nih.gov/8021861"},"language":"en","primary_location":{"id":"doi:10.1530/jrf.0.1000439","doi":"https://doi.org/10.1530/jrf.0.1000439","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.1000439","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/100/2/jrf_100_2_017.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/100/2/jrf_100_2_017.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023753144","display_name":"Keizo Kobayashi","orcid":"https://orcid.org/0000-0001-8821-6460","observed_orcids":["https://orcid.org/0000-0001-8821-6460"]},"institutions":[{"id":"https://openalex.org/I4405274081","display_name":"Research Institute For The Functional Peptides (Japan)","ror":"https://ror.org/011jdc128","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274081"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Kobayashi","raw_affiliation_strings":["Research Institute for the Functional Peptides, Yamagata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for the Functional Peptides, Yamagata, Japan","institution_ids":["https://openalex.org/I4405274081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022432520","display_name":"Shoko Yamashita","orcid":"https://orcid.org/0000-0003-4948-3413","observed_orcids":["https://orcid.org/0000-0003-4948-3413"]},"institutions":[{"id":"https://openalex.org/I4405274081","display_name":"Research Institute For The Functional Peptides (Japan)","ror":"https://ror.org/011jdc128","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274081"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Yamashita","raw_affiliation_strings":["Research Institute for the Functional Peptides, Yamagata 990, fapan","Princeton, NJ","Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for the Functional Peptides, Yamagata 990, fapan","institution_ids":["https://openalex.org/I4405274081"]},{"raw_affiliation_string":"Princeton, NJ","institution_ids":[]},{"raw_affiliation_string":"Tokyo","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108392927","display_name":"Hiroyoshi Hoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405274081","display_name":"Research Institute For The Functional Peptides (Japan)","ror":"https://ror.org/011jdc128","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405274081"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Hoshi","raw_affiliation_strings":["Research Institute for the Functional Peptides, Yamagata 990, fapan","Princeton, NJ","Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for the Functional Peptides, Yamagata 990, fapan","institution_ids":["https://openalex.org/I4405274081"]},{"raw_affiliation_string":"Princeton, NJ","institution_ids":[]},{"raw_affiliation_string":"Tokyo","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405274081"],"apc_list":null,"apc_paid":null,"fwci":4.7679,"has_fulltext":true,"cited_by_count":158,"citation_normalized_percentile":{"value":0.95937114,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"100","issue":"2","first_page":"439","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9010000228881836},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.824999988079071},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.906000018119812},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cumulus-expansion","display_name":"cumulus expansion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oocyte-fertilizability","display_name":"oocyte fertilizability","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bovine-oocytes","display_name":"bovine oocytes","score":0.7139999866485596},{"id":"https://openalex.org/keywords/in-vitro-oocyte-maturation","display_name":"in vitro oocyte maturation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bovine-in-vitro-fertilization","display_name":"bovine in vitro fertilization","score":0.6439999938011169},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7976188659667969},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6380388140678406},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5889719724655151},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.5338130593299866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5108518004417419},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.49907565116882324},{"id":"https://openalex.org/C87313946","wikidata":"https://www.wikidata.org/wiki/Q18031970","display_name":"Transforming growth factor, beta 3","level":5,"score":0.4821200370788574},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.47662460803985596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4746161997318268},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.45000532269477844},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.4400295615196228},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4326382279396057},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.42594683170318604},{"id":"https://openalex.org/C2775966511","wikidata":"https://www.wikidata.org/wiki/Q2275655","display_name":"In vitro maturation","level":4,"score":0.4244665205478668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4211593270301819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.380397230386734},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.31313663721084595},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3041553199291229},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.28124964237213135},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.19358274340629578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10710334777832031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05726918578147888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.052144140005111694},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/jrf.0.1000439","doi":"https://doi.org/10.1530/jrf.0.1000439","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.1000439","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/100/2/jrf_100_2_017.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:8021861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8021861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction and fertility","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1530/jrf.0.1000439","doi":"https://doi.org/10.1530/jrf.0.1000439","is_oa":true,"landing_page_url":"https://doi.org/10.1530/jrf.0.1000439","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/100/2/jrf_100_2_017.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013404121.pdf","grobid_xml":"https://content.openalex.org/works/W2013404121.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W87695565","https://openalex.org/W1546820506","https://openalex.org/W1971438031","https://openalex.org/W1974265269","https://openalex.org/W2000307365","https://openalex.org/W2000383236","https://openalex.org/W2015526940","https://openalex.org/W2030771022","https://openalex.org/W2033404814","https://openalex.org/W2038299764","https://openalex.org/W2047547035","https://openalex.org/W2059709644","https://openalex.org/W2079812680","https://openalex.org/W2110993745","https://openalex.org/W2132740950","https://openalex.org/W2135035823","https://openalex.org/W2140579868","https://openalex.org/W2147565001","https://openalex.org/W2346312073","https://openalex.org/W2407303061"],"related_works":["https://openalex.org/W2332230337","https://openalex.org/W2107152514","https://openalex.org/W2341936148","https://openalex.org/W2080874794","https://openalex.org/W2099212938","https://openalex.org/W2102413362","https://openalex.org/W7099675463","https://openalex.org/W2422460364","https://openalex.org/W1966144272","https://openalex.org/W2082943800"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,74,96,102],"carried":[3],"out":[4],"to":[5,34,119,131],"determine":[6],"the":[7,120,124,132,138],"effects":[8],"of":[9,51,110,126,141],"growth":[10,13,16,23,57,60,78,85,100,113,117,143,147],"factors":[11],"(epidermal":[12],"factor,":[14,24,58],"transforming":[15,59,77,116,146],"factors-alpha":[17],"and":[18,29,40,46,63,68,93,145],"-beta":[19],"1,":[20],"basic":[21,83],"fibroblast":[22,84],"insulin),":[25],"gonadotrophins":[26],"(LH,":[27],"FSH),":[28],"fetal":[30],"bovine":[31,52,154],"serum":[32],"added":[33],"TCM199":[35],"medium":[36,122],"on":[37,47,90],"cumulus":[38,53,66,91],"expansion":[39,67,92],"fertilization":[41],"during":[42],"in":[43,149,157],"vitro":[44,158],"maturation,":[45],"subsequent":[48],"embryonic":[49],"development":[50],"cell-enclosed":[54],"oocytes.":[55],"Epidermal":[56],"factor-alpha,":[61],"LH":[62,105],"FSH":[64],"enhanced":[65],"oocyte":[69,94],"fertilizability.":[70],"No":[71,87],"significant":[72],"effect":[73],"achieved":[75],"with":[76,82,104],"factor-beta":[79],"1":[80],"nor":[81],"factor.":[86],"additive":[88],"stimulation":[89],"fertilizability":[95],"observed":[97],"when":[98],"epidermal":[99,112,142],"factor":[101,114,144],"combined":[103],"or":[106,115],"FSH.":[107],"The":[108],"addition":[109],"either":[111],"factor-alpha":[118,148],"maturation":[121],"increased":[123],"number":[125],"fertilized":[127],"ova":[128],"that":[129],"developed":[130],"blastocyst":[133],"stage.":[134],"These":[135],"results":[136],"demonstrate":[137],"potential":[139],"use":[140],"obtaining":[150],"high":[151],"quality":[152],"mature":[153],"oocytes":[155],"for":[156],"fertilization.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}